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Tuberculous meningitis at the host-pathogen interface
van Leeuwen, L.M.
2018
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citation for published version (APA)
van Leeuwen, L. M. (2018). Tuberculous meningitis at the host-pathogen interface.
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Table of ConTenTs
Chapter 1 General Introduction 7
Chapter 2 Animal Models of Tuberculosis: Zebrafish 29 Chapter 3 Mannan core branching of lipo(arabino)mannan is
required for mycobacterial virulence in the context of innate immunity
49
Chapter 4 Modeling tuberculous meningitis in zebrafish using
Mycobacterium marinum
81
Chapter 5 Mycobacteria employ two different mechanisms to cross the blood-brain barrier
119
Chapter 6 A transgenic zebrafish model for the in vivo study of the blood and choroid plexus brain barriers using claudin 5
157
Chapter 6 addendum Claudin 5a expression during mycobacterial CNS invasion 183 Chapter 7 Characterization of ESX-1 components EccA1, EspG1 and
EspH reveals differential roles of ESX-1 substrates in the
Mycobacterium marinum infection cycle
193
Chapter 8 Genetic and clinical risk factors for tuberculous meningitis outcome
233
Chapter 9 Bacterial genotyping of CNS tuberculosis in South Africa: heterogenic Mycobacterium tuberculosis infection and predominance of lineage 4
263
Chapter 10 Summarizing Discussion 283
Addendum Nederlandse samenvatting 315
Dankwoord 321
Curriculum vitae 327
