Infant attachment and stress regulation : a neurobiological study
Luijk, P.C.M.
Citation
Luijk, P. C. M. (2010, December 9). Infant attachment and stress regulation : a neurobiological study. Retrieved from https://hdl.handle.net/1887/16225
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Infant attachment and stress regulation
A neurobiological study
Maartje P.C.M. Luijk
Printed by Mostert en van Onderen!, Leiden Cover design by Nanette Lindeman
© 2010, Maartje Luijk, Leiden University
All rights reserved. No parts of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, mechanically, by photocopy, by recording, or otherwise, without the prior permission from the author.
Infant attachment and stress regulation:
A neurobiological study
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof. mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op donderdag 9 december 2010 klokke 10.00 uur
door
Maartje Pieternel Caroline Maria Luijk
geboren te Spijkenisse
in 1983
Promotiecommissie Promotores:
Prof. dr. M. H. van IJzendoorn Prof. dr. F. C. Verhulst
Prof. dr. M. J. Bakermans-Kranenburg Co-promotor:
Dr. H. Tiemeier Overige leden:
Dr. S. Pieper Prof. dr. F. Juffer
Prof. dr. C. Schuengel (Vrije Universiteit Amsterdam)
The Generation R Study is conducted by the Erasmus Medical Center in close collaboration with the School of Law and Faculty of Social Sciences of the Erasmus University Rotterdam, the Municipal Health Service Rotterdam area, Rotterdam, the Rotterdam Homecare Foundation, Rotterdam and the Stichting Trombosedienst & Artsenlaboratorium Rijnmond (STAR), Rotterdam. We gratefully acknowledge the contribution of general practitioners, hospitals, midwives and pharmacies in Rotterdam. The first phase of the Generation R Study is made possible by financial support from the Erasmus Medical Center, Rotterdam, the Erasmus University Rotterdam and the Netherlands Organization for Health Research and Development (ZonMw). The present study was supported by additional grants from the Netherlands Organization for Scientific Research (grant no.
400-04-182, grant no. 452-04-306 (VIDI), and NWO SPINOZA prize).
1. Introduction 7 2. Attachment, depression, and cortisol: Deviant patterns in insecure- 13 resistant and disorganized infants
3. FKBP5 and resistant attachment predict cortisol reactivity in infants: 29 Gene-environment interaction
4. The association between parenting and attachment is moderated by a 41 polymorphism in the mineralocorticoid receptor gene: Evidence for
differential susceptibility
5. Attachment genes? Associations of dopaminergic, serotonergic, 49 oxytonergic and neuroplasticity candidate genes with attachment
security and disorganization
6. Discussion: Vulnerability and plasticity 63
References 71
Appendices
Samenvatting (Summary in Dutch) 85
Dankwoord (Acknowledgements) 91
Curriculum Vitae 93
