University of Groningen
Novel economic perspectives on prevention and treatment : case studies for paediatric, adolescent and adult infectious and chronic diseases
Kotsopoulos, Nikolaos
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2015
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Kotsopoulos, N. (2015). Novel economic perspectives on prevention and treatment : case studies for paediatric, adolescent and adult infectious and chronic diseases. University of Groningen.
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NOVEL ECONOMIC PERSPECTIVES ON PREVENTION AND TREATMENT
CASE STUDIES FOR PAEDIATRIC, ADOLESCENT AND ADULT INFECTIOUS AND CHRONIC DISEASES
ISBN: Book: 978-90-367-7771-1 Ebook: 978-90-367-7770-4 Coverdesign: Nikolaos Kotsopoulos
Typesetting: Nynke Tiekstra, ColtsfootMedia, Rotterdam Printed by: Ipskamp Drukkers
© Nikolaos Kotsopoulos, 2015. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or by any information storage or retrieval system, without permission in writing from the author. The copyright of previously published chapters of this thesis remains with the publisher or journal.
Novel Economic Perspectives on Prevention and Treatment
Case studies for paediatric, adolescent and adult infectious and chronic diseases
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnifi cus Prof. E. Sterken
and in accordance with the decision by the College of Deans.
This thesis will be defended in public on Friday 29 May 2015 at 12:45
by
Nikolaos Kotsopoulos born on 20 December 1977
in Patra, Greece
Supervisor Prof. M. J. Postma
Co-supervisor Dr. M. Connolly
Assessment committee Prof. B. Wilff ert
Prof. J. C. Wilschut Prof. G. Mergos
CONTENTS
Chapter 1 Introduction. Towards a re-thinking of the quantifi cation of costs and benefi ts in health care decision making 7
Research objectives 16 Part I 19
Chapter 2 The fi scal consequences of health and investments in health care: A quantitative “government perspective”
analytic framework 21 Part II 35
Chapter 3 Fiscal consequences of changes in morbidity and mortality attributed to rotavirus immunisation 37
Chapter 4 Quantifying the broader economic consequences of quadrivalent HPV immunization in Germany using a government perspective quantitative analytic framework 53 Chapter 5 Government perspective assessment of the costs and benefi ts
associated with immunizing working-aged adults in the Netherlands 69
Part III 81
Chapter 6 The fi scal consequences of ADHD in Germany: A quantitative analysis based on diff erences in educational attainment and lifetime earnings 83
Chapter 7 Assessing the economic burden and benefi t-cost of treating attention-defi cit hyperactivity disorder in Germany 97 Part IV 111
Chapter 8 Is the gap between micro – and macro-economic assessments in health care well understood? The case of vaccination and potential remedies 113
Chapter 9 The need for novel analytic economic evaluation methods 129
Summary 137
Samenvatting 141
List of publications by Nikolaos Kotsopoulos 145 Research Institute SHARE 147
Acknowledgements 151
Curriculum Vitae 152
