University of Groningen
Off balance: Regulatory and effector T cells in the pathogenesis of ANCA associated
vasculitis
Dekkema, Gerjan
DOI:10.33612/diss.127016557
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Publication date: 2020
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Dekkema, G. (2020). Off balance: Regulatory and effector T cells in the pathogenesis of ANCA associated vasculitis. University of Groningen. https://doi.org/10.33612/diss.127016557
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Off balance:
Regulatory and effector T cells in the
pathogenesis of ANCA associated vasculitis
Off balance: Regulatory and effector T cells in the pathogenesis of ANCA associated vasculitis
ISBN: 978-94-034-2643-3 (geprinte versie) ISBN: 978-94-034-2642-6 (digitaal) Copyright © 2020 G.J.Dekkema
All rights reserved. No part of this thesis may be reproduced, stored or transmitted in any way or by any means without the prior permission of the author, or when applicable, of the publishers of the scientific papers.
Cover design by Eduard Boxem
Off balance:
Regulatory and effector T cells in the
pathogenesis of ANCA associated vasculitis
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 17 juni 2020 om 18.00 uur
door
Gerrit Jan Dekkema geboren op 18 juli 1989
Promotores
Prof. dr. C.A. Stegeman Prof. dr. P. Heeringa Copromotores Dr. J.S.F. Sanders Dr. W.H. Abdulahad Beoordelingscommissie Prof. dr. S.P. Berger Prof. dr. A. Salama Prof. dr. E. Bremer
Paranimfen Theo Bijma Sanne Swart
Table of contents
Chapter 1 Introduction and aim of the thesis 10 Chapter 2 Increased miR-142-3p expression might explain reduced regulatory
T cell function in granulomatosis with polyangiitis. Frontiers in Immunology, 2019
36
Chapter 3 Low frequency of circulating CCR5 positive regulatory T cells is associated with risk for relapse in patients with granulomatosis with polyangiitis.
Manuscript in preparation
64
Chapter 4 Involvement of microRNAs in the aging-related decline of CD28 expression by human T cells.
Frontiers in Immunology, 2018
92
Chapter 5 Urinary and serum soluble CD25 complements urinary soluble CD163 to detect active renal anti-neutrophil cytoplasmic autoantibody associated vasculitis.
Nephrology, Dialysis and Transplantation, 2019
116
Chapter 6 Summary, discussion and future perspectives 140 Appendix Nederlandse samenvatting
Dankwoord Curriculum vitae Publicatielijst 166 172 178 180
