University of Groningen
Off balance: Regulatory and effector T cells in the pathogenesis of ANCA associated
vasculitis
Dekkema, Gerjan
DOI:
10.33612/diss.127016557
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Dekkema, G. (2020). Off balance: Regulatory and effector T cells in the pathogenesis of ANCA associated vasculitis. University of Groningen. https://doi.org/10.33612/diss.127016557
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Stellingen:
Behorende bij het proefschrift
Off balance:
Regulatory and effector T cells in the pathogenesis of ANCA associated vasculitis
1. The reduced suppressive function of regulatory T cells in granulomatosis with polyangiitis is in part due to miR-142-3p overexpression and concomitant inhibition of adenylyl cyclase 9 mediated suppression (Chapter 2).
2. cAMP enhancing agents restore the suppressive capacity of miR-142-3p overexpressing regulatory T cells in vitro (Chapter 2).
3. Regulatory T cell-based therapies might offer a new opportunity in the treatment of granulomatosis with polyangiitis and other autoimmune diseases (Chapter 2).
4. Patients with granulomatosis with polyangiitis can be stratified based on the frequency of CCR5 expressing regulatory T cells into patients at risk of relapse and patients in sustained remission. (Chapter 3).
5. Loss of CD28 after persistent T activation is at least partially controlled by miR-24-3p and miR27a-3p (Chapter 4).
6. Urinary and serum soluble CD25 complements to urinary soluble CD163 in the detection of renal active granulomatosis with polyangiitis (Chapter 5).
7. Urine soluble CD25 might reflect early renal involvement without clinically significant organ damage and is associated with renal T cell inflammation in renal active granulomatosis with polyangiitis (Chapter 5).
8. If you can’t explain it simply, you don’t understand it well enough. (Albert Einstein) 9. If you believe it will work out, you’ll see opportunities. If you believe it won’t, you will see
obstacles. (Wayne Dyer)
10. Hoe meer je het mysterie van het bestaan probeert te verklaren, hoe verder je er vanaf komt te staan. (Herman Finkers)
