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The handle http://hdl.handle.net/1887/48207 holds various files of this Leiden University dissertation

Author: Kotimaa, Juha

Title: Analysis of systemic complement in experimental renal injury and disease

Issue Date: 2017-04-25

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Analysis of systemic complement in experimental renal injury and disease

by

juha kotimaa

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Analysis of systemic complement in experimental renal injury and disease

© Juha Kotimaa, 2017

All rights are reserved. No part of this publication may be reproduced, stored, or transmitted in any form or by any means, without permission of the copyright owners.

ISBN/EAN 9789462956018

Layout by Kimmo Virtanen | VanhaVirta.fi

Image credits: Front Cover (CANstockphoto 7929382), Chapter 1 (Wellcome Images L0033026), Chapter 2 (CANstockphoto 33754903), Chapter 3 (CANstockphoto 7929462), Chapter 4 (CANstockphoto 7929390), Chapter 5 (CANstockphoto 33760346), Chapter 6 (Chapter 23107512), Chapter 7 (CANstockphoto 24655796), Back cover (adapted from CANstockphoto 7929382, 33754903, 7929462).

Printed and published by: ProefschriftMaken | Proefschriftmaken.nl

The research presented in this thesis was performed at the Department of Nephrology of the Leiden University Medical Center, The Netherlands, Hycult Biotech b.v. Uden, the Netherlands.

This Ph.D. project was supported by grants awarded by European Union to projects TransVIR (2008

#238756) and DIRECT (GA 602699).

Printing of this thesis was financially supported by: Hycult Biotech

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Analysis of systemic complement in experimental renal injury and disease

Proefschrift

Ter verkrijging van

de graad van doctor aan de Universiteit Leiden, op gezag van de Rector Magnificus Prof. mr. C.J.J.M Stolker,

volgens besluit van het College voor Promoties te verdedigen op dinsdag 25 april 2017

klokke 15.00 uur.

door

Juha Kotimaa

Born in Helsinki, Finland

May 1981

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Promotor: Prof. dr. C. van Kooten Prof. dr. M.R. Daha

Leden promotiecommissie: Prof dr P.S. Hiemstra

Prof dr L.P.W.J. van den Heuvel (Radboudumc) Prof dr F.A. Ossendorp

Dr I.Bajema Dr L.A. Trouw

Dr M.A. Seelen (UMCG)

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Ilonalle

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contents

Chapter 1 General Introduction

Chapter 2 Functional assessment of rat complement pathway activities and quantification of soluble C5b-9 in an experimental model of renal ischemia/reperfusion injury

Journal of Immunological Methods, Volume 412, October 2014, Pages 14—23

Chapter 3 Functional assessment of mouse complement pathway activities and quantification of C3b/C3c/iC3b in an experimental model of mouse renal ischaemia/reperfusion injury

Journal of Immunological Methods, Volume 419, April 2015, Pages 25—34

Chapter 4 An essential role for complement receptor C5L2 in the pathogenesis of renal ischemia-reperfusion injury

Submitted

Chapter 5 Properdin binding independent of complement activation in an in vivo model of anti-GBM disease

In preparation

Chapter 6 Sex matters: Systemic complement activity of female C57BL/6J and BALB/cJ mice is limited by serum terminal pathway components

Molecular Immunolog y, Volume 76, August 2016, Pages 13—21 Chapter 7 Dietary interventions result in modulation of hepatic and renal

expression of complement system genes in C57BL/6 mice Submitted

Chapter 8 General discussion Chapter 9 Nederlandse samenvatting

English summary

Suomenkielinen tiivistelmä Chapter 10 Acknowledgements

Curriculum vitae Bibliography Abbreviations

9 59

85

111

139

165

189

217 245

273

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