Dopamine D2 receptors in the pathophysiology of insulin resistance
Leeuw van Weenen, J.E. de
Citation
Leeuw van Weenen, J. E. de. (2011, October 5). Dopamine D2 receptors in the
pathophysiology of insulin resistance. Retrieved from https://hdl.handle.net/1887/17899
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/17899
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Dopamine D2 receptors in the pathophysiology of insulin resistance
Judith Carlier-de Leeuw van Weenen
Dopamine D2 receptors in the pathophysiology of insulin resistance
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof. mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op woensdag 5 oktober 2011 klokke 15.00 uur
door
Judith Elisabeth de Leeuw van Weenen geboren te Zürich (Zwitserland)
in 1980
Promotiecommissie
Promotor: Prof. dr. H. Pijl
Overige leden: Prof. dr. A.J.W. Scheurink (Universiteit Groningen) Prof. dr. J.A. Romijn (AMC, Amsterdam)
Prof. dr. E.R. de Kloet Dr. B. Guigas
The work described in this thesis was performed at the department of Endocrinology and Metabolic Diseases at the Leiden University Medical Center, Leiden, the Netherlands.
The project was financially supported by a grant from the Dutch Diabetes Research Foundation (project 2002.01.005).
Colophon
© J.E. Carlier-de Leeuw van Weenen, 2011
All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means without the prior written permission of the author.
ISBN 978 94 6108 193 3
Printed by Gildeprint Drukkerijen
The printing of this thesis was financially supported by:
The Dutch Diabetes Research Foundation J.E. Jurriaanse Stichting
Novo Nordisk B.V.
Novartis Pharma B.V.
Research Diet Services B.V.
Table of contents
Chapter 1 9
General Introduction
Chapter 2 37
Four weeks high fat feeding induces insulin resistance without affecting dopamine release or gene expression patterns in the hypothalamus of C57Bl6 mice
Brain Research 2009; 1250: 141-148
Chapter 3 55
Blocking dopamine D2 receptors by haloperidol curtails the beneficial impact of calorie restriction on the metabolic phenotype of high fat diet induced obese mice
Journal of Neuroendocrinology 2011; 23: 158-167
Chapter 4 75
Pharmacological modulation of dopamine receptor D2 mediated transmission alters the metabolic phenotype of diet induced obese and diet resistant C57Bl6 mice
Experimental Diabetes Research 2011; 2011: 928523
Chapter 5 93
Effects of olanzapine and haloperidol on the metabolic status of healthy menJournal of Clinical Endocrinology and Metabolism 2010; 95: 118-125
Chapter 6 109
The dopamine receptor D2 agonist bromocriptine inhibits glucose- stimulated insulin secretion by direct activation of the α2-adrenergic receptors in beta cells
Biochemical Pharmacology 2010; 79: 1827-1836
Chapter 7 133
General Discussion
Chapter 8 149
Summary Samenvatting List of Abbreviations
Curriculum Vitae and Publications 162 Dankwoord 164
