Cover Page
The handle
http://hdl.handle.net/1887/137305
holds various files of this Leiden University
dissertation.
Author: Mol, E.A.
Extracellular vesicle therapeutics
for cardiac repair
Extracellular vesicle therapeutics for cardiac repair. A translational perspective © Emma A. Mol, 2020
ISBN: 978-94-6380-867-5
Cover and lay out: wenz iD.nl || Wendy Schoneveld Printed by: ProefschriftMaken || Proefschriftmaken.nl
Extracellular vesicle therapeutics for cardiac repair
A translational perspective
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op woensdag 7 oktober 2020
klokke 11:15 uur
door
Emma Alise Mol geboren op 3 oktober 1992
Promotoren Prof. Dr. M.J.T.H. Goumans Prof. Dr. J.P.G. Sluijter Co-promotor Dr. P. Vader Promotiecommissie Prof. Dr. R.C. Hoeben Prof. Dr. D.E. Atsma Prof. Dr. A.J. van Zonneveld
CHAPTER 1 Introduction: Cardiac progenitor-cell derived exosomes as cell-free therapeutic for cardiac repair
9
CHAPTER 2 Higher functionality of extracellular vesicles isolated using size-exclusion chromatography compared to ultracentrifugation
23
CHAPTER 3 Cardiac progenitor-derived extracellular vesicles do not reduce infarct size after myocardial infarction in mice, independently of isolation method
33
CHAPTER 4 Injectable supramolecular ureidopyrimidinone hydrogels provide sustained release of extracellular vesicle therapeutics
49
CHAPTER 5 Effect of storage conditions on extracellular vesicle functionality
in vitro and in vivo
67
CHAPTER 6 Summary and general discussion 83
