University of Groningen
Gene-environment interactions in disruptive behaviors
Ruisch, Hyun
DOI:
10.33612/diss.136546089
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Publication date: 2020
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Ruisch, H. (2020). Gene-environment interactions in disruptive behaviors. University of Groningen. https://doi.org/10.33612/diss.136546089
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Gene-environment interactions in
disruptive behaviors
Colofon
ISBN (print): 978-94-034-2769-0 ISBN (digital): 978-94-034-2770-6 Printed: Printenbind.nl, Amsterdam
This work was supported by the European Community’s Seventh Framework Programme (EU-FP7), under Grant agreement no. 603016 (MATRICS).
Copyright © Hyun Ruisch, 2020.
No part of this thesis may be reproduced, distributed or transmitted in any form or by any means without prior written permission of the author.
Gene-environment interactions in
disruptive behaviors
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op dinsdag 17 november 2020 om 12.45 uur
door
Hyun Ruisch
geboren op 23 januari 1988Promotores
Prof. dr. P.J. Hoekstra Prof. dr. J.K. BuitelaarCopromotores
Dr. A. Dietrich Dr. G.J.V. PoelmansBeoordelingscommissie
Prof. dr. A. Popma Prof. dr. D. Posthuma Prof. dr. H. SniederContents
Chapter 1 | General introduction and thesis outline 7 Chapter 2 | Maternal substance use during pregnancy and offspring conduct
problems: a meta-analysis 23
Chapter 3 | Pregnancy risk factors in relation to oppositional-defiant and conduct disorder symptoms in the Avon Longitudinal Study of Parents and Children 59 Chapter 4 | Interplay between genome-wide implicated genetic variants and
environmental factors related to childhood antisocial behavior in the UK ALSPAC
cohort 79
Chapter 5 | Genome-wide study of gene-based interactions with four environmental risk factors for disruptive behavior in children and adolescents 99 Chapter 6 | Aggression based genome-wide, glutamatergic, dopaminergic and
neuroendocrine polygenic risk scores predict callous-unemotional traits 129 Chapter 7 | Aggression polygenic risk scores are related to white-matter
microstructure in the right internal capsule 159 Chapter 8 | Summary and general discussion 177
Appendices 195
Nederlandstalige wetenschappelijke samenvatting (in Dutch) 196
Dankwoord (in Dutch) 199
