University of Groningen
Applications of functional dyes in biomedicine and life sciences
Huang, Jingyi
DOI:
10.33612/diss.123828369
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Huang, J. (2020). Applications of functional dyes in biomedicine and life sciences. University of Groningen. https://doi.org/10.33612/diss.123828369
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Applications of Functional Dyes in
Biomedicine and Life Sciences
Applications of Functional Dye in Biomedical and Life Sciences
Jingyi Huang PhD thesis
University of Groningen
Zernike Institute PhD thesis series 2020-12 ISSN: 1570-1530
ISBN: 978-94-034-2686-0 (printed version) ISBN: 978-94-034-2687-7 (electronic version)
The research described in thesis was performed in Polymer Chemistry and Bioengineering group at Zernike Institute for Advanced Materials, University of Groningen, the Netherlands. This work was financially supported by Chinese Scholarship Council (CSC), University of Groningen and Netherlands Organization for Science Research (NWO).
Cover design by: Jingyi Huang & Shuo Yang Printed by: Proefschriftmaken
Applications of Functional Dyes in
Biomedicine and Life Sciences
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. E. Sterken
and in accordance with the decision by the College of Deans. This thesis will be defended in public
on
Friday 8 May 2020 at 11.00 hours by
Jingyi Huang
born on 21 July 1986 in Hebei, China
Supervisor
Prof. dr. Andreas Herrmann
Assessment committee
Prof. dr. Johan Hofkens Prof. dr. Christoph Arenz Prof. dr. Antoine van Oijen
Dedicated to my beloved husband Shuo Yang
Contents
Chapter 1 Desigen of Functional Dyes for Advanced Microscopy
and Life-sciences ...
11.1 Introduction ... 2
1.2 Organic fluorophores for super-resolution microscopy ... 2
1.3 Photoswitches for photocontrolled biomolecules ... 19
1.4 Thesis Motivation and Overview ... 29
Chapter 2 A Simple and Versatile Design Concept for
Fluorophore-derivatives with Intramolecular Photostabilization
...
392.1 Introduction ... 40
2.2 Result and Discussion ... 42
2.3 Conclusion ... 54
2.4 Experimental Section ... 55
Chapter 3 Photostabilizer-Rhodamine Conjugates for
Biomolecules Labelling and STED Microscopy ...
733.1 Introduction ... 74
3.2 Result and Discussion ... 76
3.3 Conclusion ... 84
Chapter 4 Overcoming Bacterial Resistant by Photo-switchable
Antibiotic ...
1014.1 Introduction ... 102
4.2 Result and Discussion ... 103
4.3 Conclusion ... 110
4.4 Experimental Section ... 111
C
hapter 5 Light-regulated RNA–small Molecule Interactions ..
1265.1 Introduction ... 127
5.2 Result and Discussion ... 127
5.3 Conclusion ... 137
5.4 Experimental Section ... 138
