University of Groningen
The use of organoids in the study of radiation response and therapeutic window
Nagle, Peter
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Publication date: 2018
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Nagle, P. (2018). The use of organoids in the study of radiation response and therapeutic window. University of Groningen.
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The use of organoids in the
study of radiation response and
therapeutic window
Nagle, P.W.K.
The use of organoids in the study of radiation response and therapeutic window PhD dissertation, University of Groningen, The Netherlands
ISBN (printed version): 978-94-034-0965-8 ISBN (electronic version): 978-94-034-0964-1
© Copyright 2018, Peter Nagle. All rights reserved. No parts of this thesis may be reprodu-ced, stored in a retrieval system or transmitted in any form or by any means without prior permission of the author, or when appropriate, of the publisher of the published articles. Cover design and layout: Eduard Boxem
The use of organoids in the
study of radiation response and
therapeutic window
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. E. Sterken
and in accordance with the decision by the College of Deans. This thesis will be defended in public on Wednesday 3 October 2018 at 14.30 hours
by
Peter William Kevin Nagle born on 10 September 1986
Supervisors
Prof. R.P. Coppes Prof. J.A. Langendijk
Assessment Committee
Prof. M.A.T.M. van Vugt Prof. N. Cordes
Paranymphs
Cecilia Rocchi Sarah A. Pringle
TABLE OF CONTENTS
Chapter 1
General Introduction
Chapter 2
ΔNp73 enhances promoter activity of TGF-β induced genes.
PLoS One 2012;7(12):e50815
Chapter 3 A novel role of Hsp70 in the DNA damage response
Manuscript in preparation.
Chapter 4
mTOR pathway as a target to reduce cancer stemness in esophageal cancer
Manuscript in preparation.
Chapter 5
The in vitro response of tissue stem cells to irradiation with different LETs
International Journal of Radiation Oncology Biology Physics 2016;95(1):103-11
Chapter 6
Lack of DNA damage response at low radiation doses in adult stem cells results in organ dysfunction.
Clinical Cancer Research – manuscript accepted
Chapter 7
Summary and Future Perspectives
Appendices Dutch Summary Acknowledgements Curriculum vitae List of publications 9 37 71 95 125 147 181 197 202 207 209
