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University of Groningen The role of human CBX proteins in human benign and malignant hematopoiesis Jung, Johannes

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University of Groningen

The role of human CBX proteins in human benign and malignant hematopoiesis

Jung, Johannes

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from

it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date:

2018

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Jung, J. (2018). The role of human CBX proteins in human benign and malignant hematopoiesis. University

of Groningen.

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THE ROLE

OF HUMAN CBX PROTEINS

IN HUMAN

BENIGN AND MALIGNANT

HEMATOPOIESIS

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Research was funded by:

Mildred-Scheel scholarship of the German Cancer Aid, Bonn Dutch Cancer Society, Amsterdam, The Netherlands

Printing: Eikon +

Cover & layout: Lovebird design. www.lovebird-design.com ISBN (print): 978-94-034-0905-4

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The role of human CBX proteins in

human benign and malignant

hematopoiesis

PhD thesis

to obtain the degree of PhD at the University of Groningen

on the authority of the Rector Magnificus Prof. E. Sterken

and in accordance with the decision by the College of Deans. This thesis will be defended in public on Monday 17 September 2018 at 09.00 hours

by

Johannes Benjamin Jung

born on 13 December 1981 in Freiburg im Breisgau, Germany

Supervisor

Prof. G. de Haan

Co-supervisor

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Assessment Committee

Prof. G.A. Huls Prof. J. Gil Prof. C. Lengerke

The role of human CBX proteins in

human benign and malignant

hematopoiesis

PhD thesis

to obtain the degree of PhD at the University of Groningen

on the authority of the Rector Magnificus Prof. E. Sterken

and in accordance with the decision by the College of Deans. This thesis will be defended in public on Monday 17 September 2018 at 09.00 hours

by

Johannes Benjamin Jung

born on 13 December 1981 in Freiburg im Breisgau, Germany

Supervisor

Prof. G. de Haan

Co-supervisor

(6)

TABLE OF CONTENTS

CHAPTER 1

Introduction and Outline of the thesis

9

CHAPTER 2

Do Hematopoietic Stem Cells get old?

35

CHAPTER 3

Hematopoiesis during development, aging and disease

47

CHAPTER 4

The role of CBX proteins in human benign and malignant

hematopoiesis

65

CHAPTER 5

Summary and Future Perspectives

125

APPENDICES

Nederlandse samenvatting

143

Acknowledgments

158

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For my wife Sonja, my daughter Sarah

and my parents

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The role of human CBX proteins in human benign and malignant hematopoiesis Jung, Johannes.. IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if