University of Groningen The role of human CBX proteins in human benign and malignant hematopoiesis Jung, Johannes

University of Groningen

The role of human CBX proteins in human benign and malignant hematopoiesis Jung, Johannes

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Publication date: 2018

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Jung, J. (2018). The role of human CBX proteins in human benign and malignant hematopoiesis. University of Groningen.

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STELLINGEN

The role of human CBX proteins in human benign

and malignant hematopoiesis

1. Polycomb proteins assemble in large, combinatorial

highly variable complexes that include also non-Poly-comb proteins to regulate transcription of genes involved in stemness, DNA-repair and development. (Di Croce et al., Nature Structural & Molecular Biology, 2013)

2. Mutations in or dysregulation of genes coding for

epigen-etic proteins can lead to cancer. (Sauvageau et al., Cell Stem Cell 2010)

3. Epigenetic proteins are crucial regulators of self-renewal

and differentiation of human hematopoietic stem and progenitor cells. (This thesis)

4. CBX7 is an evolutionary conserved essential regulator of

hematopoietic stem and progenitor cells. (This thesis)

5. CBX7 is a putative oncogene in the hematopoietic system

and qualifies as a potential target in AML. (This thesis)

6. Polycomb proteins interact with trimethylated

non-his-tone proteins allowing crosstalk to other epigenetic path-ways. (This thesis)

7. The interaction of CBX7 and SETDB1 is essential for the

differentiation block in AML cells (This thesis)

8. Everything is theoretically impossible until it is done.

(Robert A Heinlein)

9. Science is a way of thinking much more than it is a body