University of Groningen Complement modulation in renal replacement therapy Poppelaars, Felix

increased complement activation, as well as increased complement activity and the loss of complement inhibitors have all been linked to a higher risk of cardiovascular disease

We found that lower plasma mannose-binding lectin (MBL) levels are associated with a higher incidence of cardiac (C-event) and cardiovascular events (CV-event) in hemodialysis

To investigate the mechanism of increased cardiovascular risk in HD, we measured complement activation, pro-inflammatory cytokines, and a pro-thrombotic factor during one HD

Furthermore, in the ex-vivo assay, ferric carboxymaltose and iron sucrose only caused significant complement activation in the blood of HD patients.. No in-vitro or ex-vivo

MA: Local renal complement C3 induction by donor brain death is associated with reduced renal allograft function after transplantation.. Damman J, Daha MR, Leuvenink HG, van Goor

Increasing concentrations of C1-INH combined with heparinoids were added to pooled human plasma samples (x-axis).. The dashed line represents the upper limit of

Treatment with C1-INH also improved renal function and reduced renal injury, reflected by the significantly lower KIM-1 gene expression and lower serum levels of LDH

MA: Local renal complement C3 induction by donor brain death is associated with reduced renal allograft function after transplantation. Damman J, Bloks VW, Daha MR, van der Most