University of Groningen
Improving weak links in the diagnosis and treatment of tuberculosis
Saktiawati, Morita
DOI:
10.33612/diss.95429960
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Publication date: 2019
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Saktiawati, M. (2019). Improving weak links in the diagnosis and treatment of tuberculosis. University of Groningen. https://doi.org/10.33612/diss.95429960
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IMPROVING WEAK LINKS IN THE DIAGNOSIS AND
TREATMENT OF TUBERCULOSIS
Publication of this thesis was financially supported by the Groningen University Institute for Drug Exploration (GUIDE) - Graduate School of Medical Sciences (GSMS), University Medical Center Groningen, and Universitas Gadjah Mada.
Cover Antonia M. I. Saktiawati and Timoteus Anggawan K. Layout Off Page, Amsterdam
Printed by Off Page, Amsterdam ISBN 978-94-034-1915-2
ISBN 978-94-034-1914-5 (electronic version) © Antonia M. I. Saktiawati 2019.
Copyright of the published articles is with the corresponding journal or otherwise with the author. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, without the prior permission in writing from the author or the copyright-owning journal.
Improving weak links in the
diagnosis and treatment of
tuberculosis
Phd thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus prof. C. Wijmenga
and in accordance with the decision by the College of Deans. This thesis will be defended in public on Wednesday 18 September 2019 at 14.30 hours
by
Antonia Morita Iswari Saktiawati
born on 29 March 1984 in Yogyakarta, Indonesia
TABLE OF CONTENTS
Chapter 1 General introduction 7
Chapter 2 Sensitivity and specificity of routine diagnostic work-up for 23
tuberculosis in lung clinics in Yogyakarta, Indonesia: a cohort study
Chapter 3 Sensitivity and specificity of an electronic nose in diagnosing 41
pulmonary tuberculosis among patients with suspected tuberculosis in Indonesia
Chapter 4 Diagnosis of tuberculosis through breath test: a systematic review 61
Chapter 5 Impact of food on the pharmacokinetics of first-line anti-TB 89
drugs in treatment-naïve TB patients: a randomized cross-over trial
Chapter 6 Optimal sampling strategies for therapeutic drug monitoring of 107
first-line tuberculosis drugs in patients with tuberculosis
Chapter 7 Early bactericidal activity of Colistin sulphomethate sodium dry 123
powder inhalation and intravenous Kanamycin in patients with pulmonary tuberculosis: a proof of principle randomized trial
Chapter 8 Discussion and future perspectives 139
Chapter 9 Summary 149
Samenvatting Ringkasan
Acknowledgments 166
About the author 169
List of publications 170
Supervisors
Prof. T.S. van der Werf Prof. Y. Stienstra
Co-supervisor
Dr. Y. W. Subronto
Assessment Committee
Prof. H.A.M. Kerstjens Prof. R. van Crevel Prof. B. Wilffert
