Radiotherapy in bone metastasis : the Dutch bone metastasis study Linden, Y.M. van der

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(1)Radiotherapy in bone metastasis : the Dutch bone metastasis study Linden, Y.M. van der. Citation Linden, Y. M. van der. (2005, May 11). Radiotherapy in bone metastasis : the Dutch bone metastasis study. Retrieved from https://hdl.handle.net/1887/4330 Version:. Corrected Publisher’s Version. License:. Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden. Downloaded from:. https://hdl.handle.net/1887/4330. Note: To cite this publication please use the final published version (if applicable)..

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(41) NOCOMPLAINTS. " NPOUITJOHSPVQ# BOENPOUITJOHSPVQ$"UUIFFOEPGUIF NPOUITUVEZQFSJPE PGUIFQBUJFOUTJOHSPVQ"BOEJOHSPVQ# IBEEJFE*OHSPVQ$ PGUIFQBUJFOUTSFNBJOFEBMJWF4VSWJWJOHQBUJFOUT IBEBNFBOGPMMPXVQPGNPOUIT SBOHF . . 0OINTS. /VERALLSURVIVA. OGNOSTICFACTORS. &)'52% 3URVIVALCURVESFORTHEADJUSTEDSCORINGSYSTEMBASEDONPROGNOSTIC FACTORSINPATIENTSWITHSPINALMETASTASESWHOWERETREATED WITHINTHE$UTCH"ONE-ETASTASIS3TUDY. $ISCUSSION 'ROUP#. 5IFQSFTFOUTUVEZTIPXFEUIBUNFEJBOPWFSBMMTVSWJWBMPGQBUJFOUTJOUIF%VUDI #POF.FUBTUBTJT5SJBMXIPIBE)BSSJOHUPOµ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µ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¾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¾HVSF TIPXTUIFTVSWJWBMDVSWFT5IFNFEJBOPWFSBMMTVSWJWBMXBTNPOUITJOHSPVQ. 4!",%02%$)#4).'3526)6!,53).'4(%3#/2).'3934%-).0!4)%.437)4(30).!,-%4!34!3%342%! 7)4().4(%$54#("/.%-%4!34!3)3345$9 'ROUP. 4OTAL POINTS. ! " #. . . . . -EAN /3 . #) A . -EDIAN /3 . 0 VALUE B. . (2 . . . A/3OVERALLSURVIVALINMONTHS

(42) CONlDENCEINTERVALBETWEENBRACKETS B#OXPROPORTIONALHAZARDSMODELFORUNIVARIATEANALYSISWITH0 VALUE

(43) HAZARDRATIOANDCONlDENCEINTERVAL0ROGNOSTIC WERE+ARNOFSKY0ERFORMANCE3CORE

(44) TYPEOFPRIMARYTUMOR

(45) ANDVISCERALINVOLVEMENT.

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¾OEJOHJOUIFTDPSJOHTZTUFNPG5PNJUBFUBMXBTUIBUUIFQFSGPS NBODFTUBUVTPGUIFQBUJFOUXBTOPUJODPSQPSBUFEJOUPUIFTDPSJOHTZTUFN. 4!",%$%3)'./&3#/2).'3934%-3&/24(%352')#!,42%!4-%.4 /&30).!,-%4!34!3%3"!3%$/.,)&%%80%#4!.#9 0ATIENT#HARACTERISTICS. 4OKUHASHI A. %NKAOUA B. 4OMITA C. 0ERFORMANCESTATUS 0OOR -ODERATE 'OOD . . . . .OOFEXTRASPINALBONEMETASTASES * . . . . .OOFMETASTASESINTHEVERTEBRALBODY * . . . -ETASTASESTOMAJORINTERNALORGANS )RREMOVABLE 2EMOVABLE .OMETASTASES. . . . 0RIMARYSITEOFTHECANCER ,UNG

(47) STOMACH

(48) UNKNOWND D +IDNEY

(49) LIVER

(50) UTERUS

(51) OTHER

(52) UNKNOWN 4HYROID

(53) PROSTATE

(54) BREAST

(55) RECTUM. . . . 3PINALCORDPALSY #OMPLETE )NCOMPLETE .ONE. . . . E. A4OKUHASHI9

(56) -ATSUZAKI(

(57) 4ORIYAMA3

(58) +AWANO(

(59) /HSAKA33CORINGSYSTEMFORTHE PREOPERATIVEEVALUATIONOFMETASTATICSPINETUMORPROGNOSIS3PINE B%NKAOUA%!

(60) $OURSOUNIAN,

(61) #HATELLIER'

(62) -ABESOONE&

(63) !IMARD4

(64) 3AILLANT'6ERTEBRAL METASTASESACRITICALAPPRECIATIONOFTHEPREOPERATIVEPROGNOSTICTOKUHASHISCOREINA SERIESOFCASES3PINE C4OMITA+

(65) +AWAHARA.

(66) +OBAYASHI4

(67) 9OSHIDA!

(68) -URAKAMI(

(69) !KAMARU43URGICALSTRATEGY FORSPINALMETASTASES3PINE D0ATIENTSWITHAMETASTASISFROMANUNKNOWNPRIMARYTUMORRECEIVEDPOINTINTHE 4OKUHASHISCORING

(70) ANDPOINTSINTHE%NKAOUASCORING E0ATIENTSWITHMULTIPLEMETASTASES RECEIVEDPOINTSINTHE4OMITASCORING. 4!",%02/'./34)#'2/503/&4(%3#/2).'3934%-3"94/+5(!3()

(71) A%.+!/5!

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(73) -ATSUZAKI(

(74) 4ORIYAMA3

(75) +AWANO(

(76) /HSAKA33CORINGSYSTEMFORTHEPREOPERATIVEEVALUATIONOFMETASTATICS PROGNOSIS3PINE B%NKAOUA%!

(77) $OURSOUNIAN,

(78) #HATELLIER'

(79) -ABESOONE&

(80) !IMARD4

(81) 3AILLANT'6ERTEBRALMETASTASESACRITICALAPPRECIATIONOF PROGNOSTICTOKUHASHISCOREINASERIESOFCASES3PINE C4OMITA+

(82) +AWAHARA.

(83) +OBAYASHI4

(84) 9OSHIDA!

(85) -URAKAMI(

(86) !KAMARU43URGICALSTRATEGYFORSPINALMETASTASES3PINE &ORAANDB

(87) PROGNOSTICFACTORSUSEDWEREPERFORMANCESTATUS

(88) NUMBEROFEXTRASPINALMETASTASES

(89) NUMBEROFMETASTASESWITHIN PRESENCEOFVISCERALMETASTASES

(90) PRIMARYSITE

(91) ANDPRESENCEOFSPINALCORDPALSY&ORC

(92) PROGNOSTICFACTORSUSEDWERENUMBEROF METASTASES

(93) PRESENCEOFVISCERALMETASTASES

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(96) #OLLINS3,

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(98) ,EER*7

(99) VAN(OUWELINGEN(

(100) 0OST7*

(101) VANDEN(OUT7"

(102) +IEVIT*ETAL4HEEFFECTOF SINGLEFRACTIONCOMPAREDTOMULTIPLEFRACTIONSONPAINFULBONEMETASTASESAGLOBALANALYSISOF $UTCH"ONE-ETASTASIS3TUDY 2ADIOTHER/NCOL VANDER,INDEN9-

(103) ,OK**

(104) 3TEENLAND%

(105) -ARTIJN(

(106) (OUWELINGEN*#

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(108) /LSCHEWSKI-

(109) &AYERS0

(110) ETAL-EASURINGTHEQUALITYOFLIFEOFCANCERPATIENTSWITHTHE 2OTTERDAM3YMPTOM#HECKLIST23#, AMANUAL

(111) .ORTHERN#ENTREFOR(EALTHCARE2ESEARCH 'RONINGEN

(112) 4HE.ETHERLANDS2EF4YPE2EPORT #HOW%

(113) 7U*

(114) (OSKIN0

(115) #OIA,

(116) "ENTZEN3

(117) "LITZER0)NTERNATIONALCONSENSUSONPALLIATIVE RADIOTHERAPYENDPOINTSFORFUTURECLINICALTRIALSINBONEMETASTASES 2ADIOTHER/NCOL +ARNOFSKY$!

(118) !BELMANN7(

(119) +RAVER,&4HEUSEOFNOTROGENMUSTARDSINTHEPALLIATIVETREATMENT OFCARCINOMAWITHPARTICULARREFERENCETOBRONCHOGENICCARCINOMA #ANCER .

(120) 4OKUHASHI9

(121) -ATSUZAKI(

(122) 4ORIYAMA3

(123) +AWANO(

(124) /HSAKA33CORINGSYSTEMFORTHEPREOPERATIVE EVALUATIONOFMETASTATICSPINETUMORPROGNOSIS 3PINE %NKAOUA%!

(125) $OURSOUNIAN,

(126) #HATELLIER'

(127) -ABESOONE&

(128) !IMARD4

(129) 3AILLANT'6ERTEBRALMETASTASES ACRITICALAPPRECIATIONOFTHEPREOPERATIVEPROGNOSTICTOKUHASHISCOREINASERIESOFCASES 3PINE 4OMITA+

(130) +AWAHARA.

(131) +OBAYASHI4

(132) 9OSHIDA!

(133) -URAKAMI(

(134) !KAMARU43URGICALSTRATEGYFORSPINAL METASTASES3PINE #HOW%

(135) &UNG+

(136) 0ANZARELLA4

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