Cover Page
The handle http://hdl.handle.net/1887/20608 holds various files of this Leiden University dissertation.
Author: Fischedick, Justin Title: Terpenoids for medicine Issue Date: 2013-03-13
Terpenoids for Medicine
PROEFSCHRIFT
Ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus Professor C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op 13-03-2013
door
Justin Fischedick
Geboren te New York, United States of America In 1984
Promotiecommissie
Promotor Prof. Dr. R. Verpoorte
Co-promotor Dr. Y.H. Choi
Overige leden Prof. Dr. P.G.L. Klinkhamer Prof. Dr. C.J. ten Cate Prof. Dr. I. Merfort Dr. T.A. van Beek
Dedicated to my parents!
Cover Photograph: Photographs of Salvia officinalis, Rosmarinus officinalis, and Lavandula angustifolia were taken by author. Photographs of Soxhlet and distillation apparatus were also taken by author. The Inula Britannica close up photograph was generously donated by Dr. Slađana Todorović from Institute for Biological Research
“Siniša Stanković”, University of Belgrade, Belgrade, Serbia.
ISBN: 978-94-6203-281-1
Printed by: WÖHRMANN PRINT SERVICE, 2013
Contents
Chapter 1 General Introduction 1
Chapter 2 Analysis of essential oil vapors produced by a vaporizing device
23
Chapter 3 Cannabinoid Receptor 1 Binding Activity and Quantitative Analysis of Cannabis sativa L. Smoke and Vapor
33
Chapter 4 Metabolic fingerprinting of Cannabis sativa L., cannabinoids and terpenoids for chemotaxonomic and drug standardization purposes
53
Chapter 5 Activation of antioxidant response element in mouse primary cortical cultures with sesquiterpene lactones isolated from Tanacetum parthenium
83
Chapter 6 Cytotoxic Activity of Sesquiterpene Lactones from Inula britannica on Multi-Drug Resistant Human Cancer Cell Lines
113
Chapter 7 Structure activity relationship of phenolic diterpenes from Salvia officinalis as activators of the antioxidant response element
145
Chapter 8 Conclusions and Future Perspectives 169
Summary 177
Samenvatting 179
Curriculum vitae 181
List of publications 181
Acknowledgements 182
