• No results found

Difficult-to-treat asthma : mechanisms and risk factors Veen, H.P.A.A. van

N/A
N/A
Protected

Academic year: 2021

Share "Difficult-to-treat asthma : mechanisms and risk factors Veen, H.P.A.A. van"

Copied!
11
0
0

Bezig met laden.... (Bekijk nu de volledige tekst)

Hele tekst

(1)

Citation

Veen, H. P. A. A. van. (2010, September 2). Difficult-to-treat asthma : mechanisms and risk factors. Retrieved from

https://hdl.handle.net/1887/15918

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden

Downloaded from: https://hdl.handle.net/1887/15918

Note: To cite this publication please use the final published version (if applicable).

(2)

'ĞŶĞƌĂů/ŶƚƌŽĚƵĐƟŽŶ

ŚĂƉƚĞƌ  ϭ

(3)

ϭϬ

Zϭ ZϮ Zϯ Zϰ Zϱ Zϲ Zϳ Zϴ Zϵ ZϭϬ Zϭϭ ZϭϮ Zϭϯ Zϭϰ Zϭϱ Zϭϲ Zϭϳ Zϭϴ Zϭϵ ZϮϬ ZϮϭ ZϮϮ ZϮϯ ZϮϰ ZϮϱ ZϮϲ ZϮϳ ZϮϴ ZϮϵ ZϯϬ Zϯϭ ZϯϮ Zϯϯ Zϯϰ Zϯϱ Zϯϲ Zϯϳ Zϯϴ

(4)

ŚĂƉƚĞƌϭ

ϭϭ

Zϭ ZϮ Zϯ Zϰ Zϱ Zϲ Zϳ Zϴ Zϵ ZϭϬ Zϭϭ ZϭϮ Zϭϯ Zϭϰ Zϭϱ Zϭϲ Zϭϳ Zϭϴ Zϭϵ ZϮϬ ZϮϭ ZϮϮ ZϮϯ ZϮϰ ZϮϱ ZϮϲ ZϮϳ ZϮϴ ZϮϵ ZϯϬ Zϯϭ ZϯϮ Zϯϯ Zϯϰ Zϯϱ Zϯϲ Zϯϳ Zϯϴ

/ŶƚƌŽĚƵĐƟŽŶ

ŝĸĐƵůƚͲƚŽͲƚƌĞĂƚĂƐƚŚŵĂŝƐĂŚĞƚĞƌŽŐĞŶĞŽƵƐĚŝƐŽƌĚĞƌĐŚĂƌĂĐƚĞƌŝnjĞĚďLJƉĞƌƐŝƐƚĞŶƚƐLJŵƉƚŽŵƐ͕

ĨƌĞƋƵĞŶƚĞdžĂĐĞƌďĂƟŽŶƐĂŶĚĮdžĞĚĂŝƌŇŽǁůŝŵŝƚĂƟŽŶ͕ĚĞƐƉŝƚĞƚƌĞĂƚŵĞŶƚǁŝƚŚŚŝŐŚĚŽƐĞƐŽĨ

ŝŶŚĂůĞĚ ;ŽƌŽƌĂůͿĐŽƌƟĐŽƐƚĞƌŽŝĚƐĂŶĚůŽŶŐͲĂĐƟŶŐďƌŽŶĐŚŽĚŝůĂƚŽƌƐ;ϭͲϯͿ͘/ƚŝƐƚŚŝƐŐƌŽƵƉ ŽĨ

ƉĂƟĞŶƚƐƐĞĞŶƌĞŐƵůĂƌůLJďLJƉƵůŵŽŶŽůŽŐŝƐƚƐŝŶƚŚĞŝƌƉƌĂĐƟĐĞ͕ǁŚŝĐŚƐŽŵĞƟŵĞƐƉŽƐĞĂŵĂũŽƌ

ĐůŝŶŝĐĂůĐŚĂůůĞŶŐĞ͘ƉĂƌƚĨƌŽŵŽƌĂůĐŽƌƟĐŽƐƚĞƌŽŝĚƐĂŶĚĂŶƟͲ/Ő͕ǁŚŝĐŚŚĂƐƌĞĐĞŶƚůLJďĞĐŽŵĞ

ĂĐĐĞƐƐŝďůĞĨŽƌƉĂƟĞŶƚƐǁŝƚŚƐĞǀĞƌĞĂƚŽƉŝĐĂƐƚŚŵĂ;ϰͿ͕ƚŚĞƌĞĂƌĞŶŽĂůƚĞƌŶĂƟǀĞĂĚĚͲŽŶĚƌƵŐƐ

ĐƵƌƌĞŶƚůLJ ĂǀĂŝůĂďůĞ͘ dŚĞƌĞĨŽƌĞ͕ ƉĂƟĞŶƚƐ ǁŝƚŚ ĚŝĸĐƵůƚͲƚŽͲƚƌĞĂƚ ĂƐƚŚŵĂ ĂƌĞ ŽŌĞŶ ƐƵīĞƌŝŶŐ

ĨƌŽŵƉĞƌƐŝƐƚĞŶƚƐLJŵƉƚŽŵƐŽĨĚLJƐƉŶŽĞĂ͕ŶŝŐŚƚƟŵĞĂǁĂŬĞŶŝŶŐƐ͕ƌĞĚƵĐĞĚĞdžĞƌĐŝƐĞƚŽůĞƌĂŶĐĞ͕

ƐŝĚĞĞīĞĐƚƐĨƌŽŵ;ŽƌĂůͿĐŽƌƟĐŽƐƚĞƌŽŝĚƐ͕ĨƌĞƋƵĞŶƚĞŵĞƌŐĞŶĐLJǀŝƐŝƚƐĂŶĚŚŽƐƉŝƚĂůĂĚŵŝƐƐŝŽŶƐ͘

&ƌŽŵĂĐůŝŶŝĐĂůƉĞƌƐƉĞĐƟǀĞ͕ƉĂƟĞŶƚƐǁŝƚŚĚŝĸĐƵůƚĂƐƚŚŵĂƌĞƉƌĞƐĞŶƚĂŚĞƚĞƌŽŐĞŶĞŽƵƐŐƌŽƵƉ͗

ƚŚĞLJĐĂŶĨŽƌĞdžĂŵƉůĞďĞĂƚŽƉŝĐŽƌŶŽƚ;ϱͿ͕ŚĂǀĞĐŚŝůĚŚŽŽĚŽŶƐĞƚŽƌĚĞǀĞůŽƉĂƐƚŚŵĂůĂƚĞƌŝŶ

ůŝĨĞ;ϲͿ͕ŚĂǀĞĨƌĞƋƵĞŶƚŽƌŝŶĨƌĞƋƵĞŶƚĞdžĂĐĞƌďĂƟŽŶƐ;ϳͿŚĂǀĞŶŽƌŵĂůůƵŶŐĨƵŶĐƟŽŶďĞƚǁĞĞŶ

ĂƐƚŚŵĂĂƩĂĐŬƐŽƌƉĞƌƐŝƐƚĞŶƚĂŝƌŇŽǁůŝŵŝƚĂƟŽŶ ;ϴͲϭϬͿ͘&ŽƌƚŚĞ ĐůŝŶŝĐŝĂŶ ŝƚ ŝƐ ŝŵƉŽƌƚĂŶƚƚŽ

ƌĞĐŽŐŶŝnjĞƚŚĞƐĞǀĂƌŝŽƵƐĂƐƚŚŵĂƉŚĞŶŽƚLJƉĞƐĂƐǁĞůůĂƐƚŚĞŝƌƵŶĚĞƌůLJŝŶŐŵĞĐŚĂŶŝƐŵƐŝŶŽƌĚĞƌ

ƚŽŽƉƟŵŝnjĞĂƐƚŚŵĂƚƌĞĂƚŵĞŶƚĨŽƌƚŚĞŝŶĚŝǀŝĚƵĂůƉĂƟĞŶƚ;Ϯ͖ϱͿ͘

dƌĞĂƚŵĞŶƚŽĨƉĂƟĞŶƚƐǁŝƚŚĂƐƚŚŵĂƐŚŽƵůĚŶŽƚŽŶůLJĐŽŶƐŝƐƚŽĨĚƌƵŐƚŚĞƌĂƉLJďƵƚŝŶĐůƵĚĞƐĂ

ƚŚŽƌŽƵŐŚĞǀĂůƵĂƟŽŶŽĨĂƐƚŚŵĂŚŝƐƚŽƌLJĂŶĚƐLJŵƉƚŽŵƐ͕ĚƌƵŐĂĚŚĞƌĞŶĐĞĂŶĚƐŝĚĞĞīĞĐƚƐĂŶĚ

ƚŚĞƉƌĞƐĞŶĐĞŽĨƉŽƚĞŶƟĂůĂƐƚŚŵĂĂŐŐƌĂǀĂƟŶŐĨĂĐƚŽƌƐƐƵĐŚĂƐƉĞƌƐŝƐƚĞŶƚĂůůĞƌŐĞŶĞdžƉŽƐƵƌĞ͕

ƐĞǀĞƌĞƐŝŶŽŶĂƐĂůĚŝƐĞĂƐĞ͕ŐĂƐƚƌŽͲŽĞƐŽƉŚĂŐĞĂůƌĞŇƵdž͕ƉƐLJĐŚŽƉĂƚŚŽůŽŐLJĂŶĚŽǀĞƌǁĞŝŐŚƚ;ϳͿ͘

dŚĞŝĚĞĂůĂƐƚŚŵĂĚƌƵŐǁŽƵůĚďĞĂ͞ŽŶĞƐŝnjĞĮƚƐĂůů͟ƚŚĞƌĂƉLJ͕ĂŶĚĐŽƌƟĐŽƐƚĞƌŽŝĚƐĐŽŵĞĐůŽƐĞ͕

ďƵƚƚŚĞŶǁŝƚŚŽƵƚĂĐĐŽŵƉĂŶLJŝŶŐƐĞǀĞƌĞƐŝĚĞĞīĞĐƚƐ;ϭϭ͖ϭϮͿ͘,ŽǁĞǀĞƌ͕ƐŝŶĐĞǁĞĂƌĞĚĞĂůŝŶŐ

ǁŝƚŚĂŚĞƚĞƌŽŐĞŶĞŽƵƐĚŝƐŽƌĚĞƌǁŝƚŚŽŶůLJĂůŝŵŝƚĞĚŶƵŵďĞƌŽĨĂǀĂŝůĂďůĞƚŚĞƌĂƉŝĞƐŝƚŝƐŵŽƌĞ

ƌĂƟŽŶĂůƚŽƐĞůĞĐƚƚŚŽƐĞƉĂƟĞŶƚƐƚŚĂƚďĞŶĞĮƚĨƌŽŵĐĞƌƚĂŝŶĚƌƵŐƐ͕ĂŶĚĂŝŵĂƚŝŶĚŝǀŝĚƵĂůŝnjĞĚŽƌ

ƉŚĞŶŽƚLJƉĞͲƐƉĞĐŝĮĐƚŚĞƌĂƉLJ͘/ŶŽƌĚĞƌƚŽƌĞĂĐŚƚŚŝƐŐŽĂůĂŵĞƟĐƵůŽƵƐĚĞƐĐƌŝƉƟŽŶŽĨĂƐƚŚŵĂ

ƉŚĞŶŽƚLJƉĞƐĚĞƐĐƌŝďŝŶŐĐůŝŶŝĐĂů͕ƉŚLJƐŝŽůŽŐŝĐĂůĂŶĚŝŶŇĂŵŵĂƚŽƌLJĨĞĂƚƵƌĞƐŝƐŝŵƉŽƌƚĂŶƚ͘

EƵŵĞƌŽƵƐ ƐƚƵĚŝĞƐ ŝŶ ƚŚĞ ĮĞůĚ ŽĨ ĚŝĸĐƵůƚͲƚŽͲƚƌĞĂƚ ĂƐƚŚŵĂ ŚĂǀĞ ĨŽĐƵƐĞĚ ŽŶ ƚŚŝƐ ƐƵďũĞĐƚ

ŝŶ ƚŚĞ ƌĞĐĞŶƚ ƉĂƐƚ͕ ďƵƚ ŵŽƌĞ ǁŽƌŬ ŶĞĞĚƐ ƚŽ ďĞ ĚŽŶĞ ;Ϯ͖ϱͿ͘ ƉĂƌƚ ĨƌŽŵ ĚĞĮŶŝŶŐ ĂƐƚŚŵĂ

ƉŚĞŶŽƚLJƉĞƐŽƚŚĞƌŝƐƐƵĞƐƌĞŵĂŝŶ͗ǁŚLJĚŽĐĞƌƚĂŝŶƉĂƟĞŶƚƐǁŝƚŚĂƐƚŚŵĂďĞĐŽŵĞĚŝĸĐƵůƚͲƚŽͲ ƚƌĞĂƚ͕ŚŽǁĐĂŶǁĞŝĚĞŶƟĨLJƉĂƟĞŶƚƐƚŚĂƚǁŝůůĚĞǀĞůŽƉĐĞƌƚĂŝŶƉŚĞŶŽƚLJƉĞƐĂƚĂŶĞĂƌůLJƐƚĂŐĞ

ĂŶĚĚŽƉŚĞŶŽƚLJƉĞƐůĂƐƚŽǀĞƌƟŵĞ͍dŚĞƐƚƵĚŝĞƐŝŶƚŚŝƐƚŚĞƐŝƐŚĂǀĞƚƌŝĞĚƚŽŵĂŬĞĂŵŽĚĞƐƚ

ĐŽŶƚƌŝďƵƟŽŶŝŶĂĚĚƌĞƐƐŝŶŐƚŚĞƐĞƋƵĞƐƟŽŶƐ͘

(5)

ϭϮ

Zϭ ZϮ Zϯ Zϰ Zϱ Zϲ Zϳ Zϴ Zϵ ZϭϬ Zϭϭ ZϭϮ Zϭϯ Zϭϰ Zϭϱ Zϭϲ Zϭϳ Zϭϴ Zϭϵ ZϮϬ ZϮϭ ZϮϮ ZϮϯ ZϮϰ ZϮϱ ZϮϲ ZϮϳ ZϮϴ ZϮϵ ZϯϬ Zϯϭ ZϯϮ Zϯϯ Zϯϰ Zϯϱ Zϯϲ Zϯϳ Zϯϴ

DĞĐŚĂŶŝƐŵƐƚŚĂƚŵĂLJĞdžƉůĂŝŶƚŚĞĚĞǀĞůŽƉŵĞŶƚŽĨƉĞƌƐŝƐƚĞŶƚĂŝƌŇŽǁůŝŵŝƚĂƟŽŶ

dŚĞ ĮƌƐƚ ƚǁŽ ƐƚƵĚŝĞƐ ĂƌĞ ĐƌŽƐƐͲƐĞĐƟŽŶĂů ƐƚƵĚŝĞƐ ůŽŽŬŝŶŐ Ăƚ ŵĞĐŚĂŶŝƐŵƐ ƚŚĂƚ ĐĂŶ ĞdžƉůĂŝŶ

ƉĞƌƐŝƐƚĞŶƚĂŝƌŇŽǁůŝŵŝƚĂƟŽŶŝŶĂƐƚŚŵĂ͘WĞƌƐŝƐƚĞŶƚĂŝƌŇŽǁůŝŵŝƚĂƟŽŶŝƐĐŽŵŵŽŶŝŶĚŝĸĐƵůƚͲ ƚŽͲƚƌĞĂƚĂƐƚŚŵĂ;ƵƉƚŽϰϵйŽĨƉĂƟĞŶƚƐͿ;ϭϯͿďƵƚƚŚĞƉĂƚŚŽƉŚLJƐŝŽůŽŐŝĐĂůŵĞĐŚĂŶŝƐŵƐĂƌĞ

ƐƟůů ƉŽŽƌůLJ ƵŶĚĞƌƐƚŽŽĚ͘ ^ƚƌƵĐƚƵƌĂů ĂůƚĞƌĂƟŽŶƐ ŝŶ ƚŚĞ ĂŝƌǁĂLJƐ ƉŽƐƐŝďůLJ ŝŶĚƵĐĞĚ ďLJ ĐŚƌŽŶŝĐ

ĂŝƌǁĂLJŝŶŇĂŵŵĂƟŽŶĂƌĞƚŚŽƵŐŚƚƚŽĐĂƵƐĞƉĞƌƐŝƐƚĞŶƚĂŝƌǁĂLJŚLJƉĞƌƌĞƐƉŽŶƐŝǀĞŶĞƐƐĂŶĚĮdžĞĚ

ĂŝƌǁĂLJŽďƐƚƌƵĐƟŽŶ;ϭϰͿ͘/ƚƌĞŵĂŝŶƐƵŶĐůĞĂƌ͕ŚŽǁĞǀĞƌ͕ǁŚŝĐŚĐŽŵƉŽŶĞŶƚƐŽĨƚŚĞĂŝƌǁĂLJǁĂůů

;ĐĞŶƚƌĂůůLJŽƌƉĞƌŝƉŚĞƌĂůůLJͿĐĂŶďĞŚĞůĚƌĞƐƉŽŶƐŝďůĞĨŽƌƚŚŝƐŵĞĐŚĂŶŝƐŵ;ϭϱͿ͘

'ĞŶĞƟĐ;ϭϲͿ͕ĞŶǀŝƌŽŶŵĞŶƚĂů;ϭϳͿĂŶĚŝŶŇĂŵŵĂƚŽƌLJĨĂĐƚŽƌƐ;ϲ͖ϴ͖ϭϬ͖ϭϴͿŚĂǀĞďĞĞŶĂƐƐŽĐŝĂƚĞĚ

ǁŝƚŚ ĂĐĐĞůĞƌĂƚĞĚ ĚĞĐůŝŶĞ ŝŶ ůƵŶŐ ĨƵŶĐƟŽŶ͘  ŐĞŶĞƟĐ ĚĞĮĐŝĞŶĐLJ ŝŶ ĂůƉŚĂͲϭͲĂŶƟƚƌLJƉƐŝŶ

ƉƌŽĚƵĐƟŽŶŝƐŬŶŽǁŶƚŽƉƌĞĚŝƐƉŽƐĞƚŽƚŚĞĚĞǀĞůŽƉŵĞŶƚŽĨĐŚƌŽŶŝĐĂŝƌŇŽǁůŝŵŝƚĂƟŽŶĂŶĚ

ĞŵƉŚLJƐĞŵĂ;ϭϵͿ͘&ƵƌƚŚĞƌŵŽƌĞ͕ŚĞƚĞƌŽnjLJŐŽƵƐdƉŚĞŶŽƚLJƉĞƐŚĂǀĞďĞĞŶĂƐƐŽĐŝĂƚĞĚǁŝƚŚ

ĂŝƌǁĂLJŚLJƉĞƌƌĞƐƉŽŶƐŝǀĞŶĞƐƐ;ϮϬͿ͘/ŶĐŚĂƉƚĞƌϯǁĞŝŶǀĞƐƟŐĂƚĞĚǁŚĞƚŚĞƌĂůƉŚĂͲϭͲĂŶƟƚƌLJƉƐŝŶ

ĚĞĮĐŝĞŶĐLJĐŽƵůĚĐŽŶƚƌŝďƵƚĞƚŽƉĞƌƐŝƐƚĞŶƚĂŝƌŇŽǁůŝŵŝƚĂƟŽŶŝŶĚŝĸĐƵůƚͲƚŽͲƚƌĞĂƚĂƐƚŚŵĂ͘

/ŶĐŚĂƉƚĞƌϰǁĞĚŝƐĐƵƐƐƚŚĞƌŽůĞŽĨƉĞƌŝƉŚĞƌĂůĂŝƌǁĂLJĚŝƐĞĂƐĞŝŶĂƐƚŚŵĂ͘/ŶŇĂŵŵĂƟŽŶŽĨƚŚĞ

ĚŝƐƚĂůůƵŶŐŝŶĂƐƚŚŵĂŚĂƐďĞĞŶĚĞŵŽŶƐƚƌĂƚĞĚŝŶƉŽƐƚŵŽƌƚĞŵƟƐƐƵĞŝŶƉĂƟĞŶƚƐǁŚŽĚŝĞĚ

ĨƌŽŵĂŶĂƐƚŚŵĂƟĐĂƩĂĐŬ;Ϯϭ͖ϮϮͿ͕ŝŶƌĞƐĞĐƚĞĚůƵŶŐƟƐƐƵĞ;ϮϯͿĂŶĚŝŶƚƌĂŶƐďƌŽŶĐŚŝĂůďŝŽƉƐŝĞƐ

ĨƌŽŵƉĂƟĞŶƚƐǁŝƚŚĂƐƚŚŵĂ;Ϯϰ͖ϮϱͿĂŶĚŚĂƐďĞĞŶƐƵŐŐĞƐƚĞĚƚŽĐŽŶƚƌŝďƵƚĞƚŽŝŶƐƚĂďŝůŝƚLJŽĨ

ƚŚĞĚŝƐĞĂƐĞ;ϮϲͿ͕ƚŚĞƌĂƉLJƌĞƐŝƐƚĂŶĐĞ;ϮϳͿĂŶĚĞdžĐĞƐƐŝǀĞĂŝƌǁĂLJŶĂƌƌŽǁŝŶŐ;ϮϴͿ͘/ŶƚŚŝƐƐƚƵĚLJ

ǁĞ ŚLJƉŽƚŚĞƐŝnjĞ ƚŚĂƚ ƚŚĞ ĚĞŐƌĞĞ ŽĨ ƉĞƌŝƉŚĞƌĂů ĂŝƌǁĂLJ ĚLJƐĨƵŶĐƟŽŶ ĂŶĚ ŝŶŇĂŵŵĂƟŽŶ ĂƌĞ

ŝŶƚĞƌƌĞůĂƚĞĚĂŶĚĂƐƐŽĐŝĂƚĞĚǁŝƚŚĂƐƚŚŵĂƐĞǀĞƌŝƚLJ͘

dŚĞŽďĞƐĞƉŚĞŶŽƚLJƉĞ

KŶĞŽĨƚŚĞĐůŝŶŝĐĂůĨĞĂƚƵƌĞƐƚŚĂƚŚĂƐďĞĞŶƌĞůĂƚĞĚƚŽĂƐƚŚŵĂƐĞǀĞƌŝƚLJŝƐŽďĞƐŝƚLJ;ďŽĚLJŵĂƐƐ

ŝŶĚĞdž ;D/Ϳ ш ϯϬͿ͘ /ƚ ŚĂƐ ďĞĞŶ ĚĞŵŽŶƐƚƌĂƚĞĚ ƚŚĂƚ ŽďĞƐŝƚLJ ůĞĂĚƐ ƚŽ Ă ƐƚĂƚĞ ŽĨ ůŽǁͲŐƌĂĚĞ

ŝŶŇĂŵŵĂƟŽŶ͕ŝŶǁŚŝĐŚĂĚŝƉŽŶĞĐƟŶĂŶĚůĞƉƟŶƉƌŽĚƵĐĞĚďLJƚŚĞŽďĞƐĞƟƐƐƵĞĂƌĞŝŶǀŽůǀĞĚ͘

dŚŝƐ ƐLJƐƚĞŵŝĐ ŝŶŇĂŵŵĂƟŽŶ ŵŝŐŚƚ ŝŶŇƵĞŶĐĞ ŝŶŇĂŵŵĂƚŽƌLJ ƉƌŽĐĞƐƐĞƐ ŝŶ ƚŚĞ ĂŝƌǁĂLJ ǁĂůů

ƚŚĞƌĞďLJĞdžĂĐĞƌďĂƟŶŐĂƐƚŚŵĂ͘KƚŚĞƌŵĞĐŚĂŶŝƐŵƐƚŚĂƚŵĂLJƉůĂLJĂƌŽůĞŝŶƚŚĞĂƐƐŽĐŝĂƟŽŶ

ďĞƚǁĞĞŶƚŚĞƚǁŽĚŝƐŽƌĚĞƌƐĂƌĞƚŚĞŵĞĐŚĂŶŝĐĂůĞīĞĐƚŽĨĂĚŝƉŽƐĞƟƐƐƵĞŽŶůƵŶŐĨƵŶĐƟŽŶĂŶĚ

ƚŚĞƉƌĞƐĞŶĐĞŽĨĐŽͲŵŽƌďŝĚĨĂĐƚŽƌƐ;ϮϵͿ͘/ŶĐŚĂƉƚĞƌϰǁĞŝŶǀĞƐƟŐĂƚĞĚǁŚĞƚŚĞƌŽďĞƐĞƉĂƟĞŶƚƐ

ǁŝƚŚĚŝĸĐƵůƚͲƚŽͲƚƌĞĂƚĂƐƚŚŵĂĚŝīĞƌŝŶĐůŝŶŝĐĂů͕ƉŚLJƐŝŽůŽŐŝĐĂůĂŶĚŝŶŇĂŵŵĂƚŽƌLJĨĞĂƚƵƌĞƐĨƌŽŵ

ƚŚĞŶŽŶͲŽďĞƐĞƉĂƟĞŶƚƐ͘

WƌĞĚŝĐƚŽƌƐŽĨĂŶĂĐĐĞůĞƌĂƚĞĚĚĞĐůŝŶĞŝŶůƵŶŐĨƵŶĐƟŽŶ

/Ŷϭϵϵϴ͕ĂƐƚƵĚLJĂŵŽŶŐŵŽƌĞƚŚĂŶϭϳϬϬϬŝŶĚŝǀŝĚƵĂůƐ͕ŽĨǁŚŽŵϲйŚĂĚƐĞůĨͲƌĞƉŽƌƚĞĚĂƐƚŚŵĂ͕

ƐŚŽǁĞĚƚŚĂƚƉĂƟĞŶƚƐǁŝƚŚĂƐƚŚŵĂŚĂĚĂŶĂǀĞƌĂŐĞĚĞĐůŝŶĞŝŶ&sϭŽĨϯϴŵůͬLJƌĂƐĐŽŵƉĂƌĞĚ

(6)

ŚĂƉƚĞƌϭ

ϭϯ

Zϭ ZϮ Zϯ Zϰ Zϱ Zϲ Zϳ Zϴ Zϵ ZϭϬ Zϭϭ ZϭϮ Zϭϯ Zϭϰ Zϭϱ Zϭϲ Zϭϳ Zϭϴ Zϭϵ ZϮϬ ZϮϭ ZϮϮ ZϮϯ ZϮϰ ZϮϱ ZϮϲ ZϮϳ ZϮϴ ZϮϵ ZϯϬ Zϯϭ ZϯϮ Zϯϯ Zϯϰ Zϯϱ Zϯϲ Zϯϳ Zϯϴ ƚŽϮϮŵůͬLJƌŝŶƚŚĞŚĞĂůƚŚLJŝŶĚŝǀŝĚƵĂůƐ;ϭϳͿ͘dŚŝƐƌĞƐƵůƚƚŽŐĞƚŚĞƌǁŝƚŚƚŚĞĮŶĚŝŶŐƚŚĂƚƵƉƚŽ

ϰϵйŽĨƉĂƟĞŶƚƐǁŝƚŚĚŝĸĐƵůƚͲƚŽͲƚƌĞĂƚĂƐƚŚŵĂŚĂƐƉĞƌƐŝƐƚĞŶƚĂŝƌŇŽǁůŝŵŝƚĂƟŽŶ;ϭϯͿƌĂŝƐĞĚ

ƚŚĞƋƵĞƐƟŽŶǁŚŝĐŚƉĂƟĞŶƚƐĂƌĞĂƚƌŝƐŬŽĨŚĂǀŝŶŐĂŶĂĐĐĞůĞƌĂƚĞĚĚĞĐůŝŶĞŝŶůƵŶŐĨƵŶĐƟŽŶ͘

WƌĞǀŝŽƵƐĐƌŽƐƐͲƐĞĐƟŽŶĂůƐƚƵĚŝĞƐŚĂǀĞƐŚŽǁŶƚŚĂƚƉĞƌƐŝƐƚĞŶƚĂŝƌŇŽǁůŝŵŝƚĂƟŽŶŝƐĂƐƐŽĐŝĂƚĞĚ

ǁŝƚŚĞŽƐŝŶŽƉŚŝůŝĐĂŝƌǁĂLJŝŶŇĂŵŵĂƟŽŶ;ϲ͖ϴ͖ϭϬͿĂŶĚƚŚĂƚŝŶĨĞĐƟŽŶǁŝƚŚƉĂƚŚŽŐĞŶƐŝŶĐůƵĚŝŶŐ

ŚůĂŵLJĚŝĂ WŶĞƵŵŽŶŝĂĞ ŝƐ ĂƐƐŽĐŝĂƚĞĚ ǁŝƚŚ ŝŶĐƌĞĂƐĞĚ ůƵŶŐ ĨƵŶĐƟŽŶ ĚĞĐůŝŶĞ ĞƐƉĞĐŝĂůůLJ ŝŶ

ŶŽŶͲĂƚŽƉŝĐĂĚƵůƚƐ;ϵͿ͕ǁŚŝĐŚǁĂƐĐŽŶĮƌŵĞĚŝŶĂůŽŶŐŝƚƵĚŝŶĂůƐƚƵĚLJ;ϯϬͿ͘&ƵƌƚŚĞƌŵŽƌĞ͕ůƵŶŐ

ĨƵŶĐƟŽŶĚĞĐůŝŶĞŚĂƐďĞĞŶƌĞůĂƚĞĚƚŽϴнĐĞůůƐŝŶďƌŽŶĐŚŝĂůďŝŽƉƐŝĞƐ;ϭϴͿĂŶĚĞdžĂĐĞƌďĂƟŽŶƐ

;ϯϭ͖ϯϮͿŝŶŽƚŚĞƌůŽŶŐŝƚƵĚŝŶĂůƐƚƵĚŝĞƐ͘

/ŶϭϵϵϴĂĐŽŚŽƌƚŽĨϭϯϲƉĂƟĞŶƚƐǁŝƚŚĚŝĸĐƵůƚͲƚŽͲƚƌĞĂƚĂƐƚŚŵĂĨƌŽŵϭϬĂĐĂĚĞŵŝĐĂŶĚŶŽŶͲ ƚĞĂĐŚŝŶŐŚŽƐƉŝƚĂůƐŝŶƚŚĞEĞƚŚĞƌůĂŶĚƐǁĂƐƌĞĐƌƵŝƚĞĚĂƚƚŚĞ>ĞŝĚĞŶhŶŝǀĞƌƐŝƚLJDĞĚŝĐĂůĞŶƚƌĞ

ƚŽ ĚĞĮŶĞ ƉŚĞŶŽƚLJƉĞƐ ŽĨ ĚŝĸĐƵůƚͲƚŽͲƚƌĞĂƚ ĂƐƚŚŵĂ ;ϳ͖ϵͿ͘ ůů ƉĂƟĞŶƚƐ ĨƵůĮůůĞĚ ƚŚĞ ĐƌŝƚĞƌŝĂ

ƉƌŽƉŽƐĞĚďLJƚŚĞZ^dĂƐŬ&ŽƌĐĞŽŶĚŝĸĐƵůƚͬƚŚĞƌĂƉLJͲƌĞƐŝƐƚĂŶƚĂƐƚŚŵĂ;ϯͿ͘/ŶŽƌĚĞƌƚŽŝĚĞŶƟĨLJ

ƌŝƐŬĨĂĐƚŽƌƐŽĨĂĐĐĞůĞƌĂƚĞĚůƵŶŐĨƵŶĐƟŽŶĚĞĐůŝŶĞǁĞƌĞͲĂƐƐĞƐƐĞĚƚŚŝƐĐŽŚŽƌƚϱͲϲLJĞĂƌƐůĂƚĞƌ͘

dŚĞƌĞƐƵůƚƐŽĨƚŚŝƐƐƚƵĚLJĂƌĞĚŝƐĐƵƐƐĞĚŝŶĐŚĂƉƚĞƌϲ͘

WĞƌƐŝƐƚĞŶĐĞŽĨƚŚĞĞŽƐŝŶŽƉŚŝůŝĐƉŚĞŶŽƚLJƉĞ

ŝĸĐƵůƚͲƚŽͲƚƌĞĂƚĂƐƚŚŵĂŝƐĂŚĞƚĞƌŽŐĞŶĞŽƵƐĚŝƐŽƌĚĞƌŶŽƚŽŶůLJĨƌŽŵĂĐůŝŶŝĐĂůƉĞƌƐƉĞĐƟǀĞ

ďƵƚ ĂůƐŽ ǁŝƚŚ ƌĞƐƉĞĐƚ ƚŽ ƚŚĞ ƚLJƉĞ ĂŶĚ ĞdžƚĞŶƚ ŽĨ ŝŶŇĂŵŵĂƚŽƌLJ ĐŚĂŶŐĞƐ ŝŶ ƚŚĞ ĂŝƌǁĂLJƐ͘

^ĞǀĞƌĂůŝŶŇĂŵŵĂƚŽƌLJƉŚĞŶŽƚLJƉĞƐŚĂǀĞďĞĞŶĚĞƐĐƌŝďĞĚŝŶƚŚĞƉĂƐƚLJĞĂƌƐ͕ŝŶƉĂƌƟĐƵůĂƌƚŚĞ

ŶŽŶͲĞŽƐŝŶŽƉŚŝůŝĐ ĂŶĚ ĞŽƐŝŶŽƉŚŝůŝĐ ƐƵďƚLJƉĞ ;ϯϯͲϯϲͿ͘ /Ŷ ĐƌŽƐƐͲƐĞĐƟŽŶĂů ƐƚƵĚŝĞƐ ŝƚ ŚĂƐ ďĞĞŶ

ĚĞŵŽŶƐƚƌĂƚĞĚ ƚŚĂƚ ƉĂƟĞŶƚƐ ǁŝƚŚ ƉĞƌƐŝƐƚĞŶƚ ĞŽƐŝŶŽƉŚŝůŝĂ ŝŶ ƐƉƵƚƵŵ Žƌ ďƌŽŶĐŚŝĂů ďŝŽƉƐŝĞƐ

ŚĂǀĞƉŽŽƌĞƌůƵŶŐĨƵŶĐƟŽŶ͕ŵŽƌĞ/hǀŝƐŝƚƐĂŶĚŵŽƌĞƐŝŶƵƐĚŝƐĞĂƐĞ;ϲ͖ϴ͖ϯϲͿ͘tŚĞŶƐƚƵĚLJŝŶŐ

ƉŚĞŶŽƚLJƉĞƐƉĞĐŝĮĐƚƌĞĂƚŵĞŶƚƐŝŶĐůŝŶŝĐĂůƚƌŝĂůƐŝƚŝƐĐƌƵĐŝĂůƚŚĂƚƚŚĞƐĞƐƉĞĐŝĮĐĨĞĂƚƵƌĞƐĂƌĞ

ŶŽƚĂŽŶĐĞͲŽŶůLJŽďƐĞƌǀĂƟŽŶďƵƚƚŚĂƚƚŚĞLJƌĞƉƌĞƐĞŶƚůŽŶŐƐƚĂŶĚŝŶŐĐŚĂƌĂĐƚĞƌŝƐƟĐƐŽĨƚŚĞƐĞ

ƉĂƟĞŶƚƐ͘/ŶĐŚĂƉƚĞƌϳǁĞƚŚĞƌĞĨŽƌĞĚŝƐĐƵƐƐǁŚĞƚŚĞƌƚŚĞ;ŶŽŶͲͿĞŽƐŝŶŽƉŚŝůŝĐƉŚĞŶŽƚLJƉĞŝƐĂ

ƉĞƌŵĂŶĞŶƚĐŚĂƌĂĐƚĞƌŝƐƟĐŽĨƉĂƟĞŶƚƐŽǀĞƌĂϱLJĞĂƌƐŝŶƚĞƌǀĂů͘

(7)

ϭϰ

Zϭ ZϮ Zϯ Zϰ Zϱ Zϲ Zϳ Zϴ Zϵ ZϭϬ Zϭϭ ZϭϮ Zϭϯ Zϭϰ Zϭϱ Zϭϲ Zϭϳ Zϭϴ Zϭϵ ZϮϬ ZϮϭ ZϮϮ ZϮϯ ZϮϰ ZϮϱ ZϮϲ ZϮϳ ZϮϴ ZϮϵ ZϯϬ Zϯϭ ZϯϮ Zϯϯ Zϯϰ Zϯϱ Zϯϲ Zϯϳ Zϯϴ

ŝŵƐŽĨƚŚĞƐƚƵĚŝĞƐ

ŚĂƉƚĞƌϮ͗/ŶƚŚŝƐĐŚĂƉƚĞƌǁĞŐŝǀĞĂŶŽǀĞƌǀŝĞǁŽĨƚŚĞĐƵƌƌĞŶƚůŝƚĞƌĂƚƵƌĞĂďŽƵƚƚŚĞĚŝĸĐƵůƚͲ ƚŽͲƚƌĞĂƚĂƐƚŚŵĂƟĐƉĂƟĞŶƚ͘dŚĞƌĞǀŝĞǁŝƐǁƌŝƩĞŶĨƌŽŵĂĐůŝŶŝĐĂůƉĞƌƐƉĞĐƟǀĞƚŽŽīĞƌĂůůƚŚŽƐĞ

ǁŚŽǁŽƌŬǁŝƚŚƚŚĞƐĞƉĂƟĞŶƚƐ͕ǁŚĞƚŚĞƌƚŚĞLJĂƌĞŶƵƌƐĞƐ͕ĚŽĐƚŽƌƐŝŶƚƌĂŝŶŝŶŐ͕ƉƵůŵŽŶŽůŽŐŝƐƚƐ

ŽƌƌĞƐĞĂƌĐŚĞƌƐ͕ĂƉƌĂĐƟĐĂůŽƵƚůŝŶĞ͘

ŚĂƉƚĞƌϯ͗/ŶƚŚŝƐƐƚƵĚLJǁĞŚLJƉŽƚŚĞƐŝnjĞĚƚŚĂƚĂŚĞƚĞƌŽnjLJŐŽƵƐ;ŶŽŶͲWŝDͿĂůƉŚĂͲϭͲĂŶƟƚƌLJƉƐŝŶ

;dͿĚĞĮĐŝĞŶƚƉŚĞŶŽƚLJƉĞŝƐĂƌŝƐŬĨĂĐƚŽƌŽĨƉĞƌƐŝƐƚĞŶƚĂŝƌŇŽǁůŝŵŝƚĂƟŽŶŝŶƉĂƟĞŶƚƐǁŝƚŚ

ĂƐƚŚŵĂ͘ dŽ ƚĞƐƚ ƚŚŝƐ ŚLJƉŽƚŚĞƐŝƐ ǁĞ ĂƐƐĞƐƐĞĚ ƚŚĞ ƉƌĞǀĂůĞŶĐĞ ŽĨ Ă ŶŽŶͲWŝD ƉŚĞŶŽƚLJƉĞ ŝŶ

ƉĂƟĞŶƚƐǁŝƚŚĚŝĸĐƵůƚͲƚŽͲƚƌĞĂƚĂƐƚŚŵĂǁŝƚŚŽƌǁŝƚŚŽƵƚƉĞƌƐŝƐƚĞŶƚĂŝƌŇŽǁůŝŵŝƚĂƟŽŶ͕ĐŽŵƉĂƌĞĚ

ůƵŶŐĨƵŶĐƟŽŶƉĂƌĂŵĞƚĞƌƐďĞƚǁĞĞŶWŝDĂŶĚŶŽŶͲWŝDƉŚĞŶŽƚLJƉĞƐ͕ĂŶĚĂŶĂůLJƐĞĚǁŚĞƚŚĞƌĂ

ŶŽŶͲWŝDƉŚĞŶŽƚLJƉĞǁĂƐĂƐƐŽĐŝĂƚĞĚǁŝƚŚĂŵŽƌĞŝŵƉĂŝƌĞĚůƵŶŐĨƵŶĐƟŽŶĂƐĐŽŵƉĂƌĞĚƚŽĂ

WŝDdƉŚĞŶŽƚLJƉĞ͘

ŚĂƉƚĞƌϰ͗dŚĞŚLJƉŽƚŚĞƐŝƐŽĨƚŚŝƐƐƚƵĚLJǁĂƐƚŚĂƚƉĂƌĂŵĞƚĞƌƐŽĨƉĞƌŝƉŚĞƌĂůĂŝƌǁĂLJĚLJƐĨƵŶĐƟŽŶ

ĂŶĚƉĞƌŝƉŚĞƌĂůĂŝƌǁĂLJŝŶŇĂŵŵĂƟŽŶĂƌĞŝŶƚĞƌƌĞůĂƚĞĚĂŶĚĂƐƐŽĐŝĂƚĞĚǁŝƚŚĂƐƚŚŵĂƐĞǀĞƌŝƚLJ͘dŽ

ƚŚĂƚĞŶĚǁĞŝŶǀĞƐƟŐĂƚĞĚĂŶĞǁƉĂƌĂŵĞƚĞƌŽĨƉĞƌŝƉŚĞƌĂůĂŝƌǁĂLJŝŶŇĂŵŵĂƟŽŶ͕ĂůǀĞŽůĂƌŶŝƚƌŝĐ

ŽdžŝĚĞ͕ĂŶĚĐŽŵƉĂƌĞĚƚŚŝƐǁŝƚŚĞƐƚĂďůŝƐŚĞĚƉĂƌĂŵĞƚĞƌƐŽĨƉĞƌŝƉŚĞƌĂůĂŝƌǁĂLJĚLJƐĨƵŶĐƟŽŶŝŶ

ƉĂƟĞŶƚƐǁŝƚŚŵŝůĚͲƚŽͲŵŽĚĞƌĂƚĞĂŶĚƐĞǀĞƌĞĂƐƚŚŵĂ͘

ŚĂƉƚĞƌϱ͗KďĞƐŝƚLJŚĂƐďĞĞŶƌĞůĂƚĞĚƚŽƚŚĞƉƌĞǀĂůĞŶĐĞŽĨĂƐƚŚŵĂĂŶĚƚŽĂƐƚŚŵĂƐĞǀĞƌŝƚLJ

ƚŚƌŽƵŐŚ ĚŝīĞƌĞŶƚ ƉŽƐƐŝďůĞ ŵĞĐŚĂŶŝƐŵƐ͘ /Ŷ ƚŚŝƐ ƐƚƵĚLJ ǁĞ ŝŶǀĞƐƟŐĂƚĞĚ ǁŚĞƚŚĞƌ ŽďĞƐĞ

ƉĂƟĞŶƚƐǁŝƚŚĚŝĸĐƵůƚͲƚŽͲƚƌĞĂƚĂƐƚŚŵĂŚĂǀĞĚŝīĞƌĞŶƚĐůŝŶŝĐĂůĂŶĚŝŶŇĂŵŵĂƚŽƌLJƉƌŽĮůĞƐĂƐ

ĐŽŵƉĂƌĞĚƚŽŶŽŶͲŽďĞƐĞƉĂƟĞŶƚƐ͘

ŚĂƉƚĞƌϲ͗/ƚŚĂƐďĞĞŶĚĞŵŽŶƐƚƌĂƚĞĚƚŚĂƚůƵŶŐĨƵŶĐƟŽŶĚĞĐůŝŶĞŝŶƉĂƟĞŶƚƐǁŝƚŚĂƐƚŚŵĂ

ŝƐŝŶĐƌĞĂƐĞĚĂŶĚƚŚĂƚƵƉƚŽϰϵйŽĨƉĂƟĞŶƚƐǁŝƚŚĚŝĸĐƵůƚͲƚŽͲƚƌĞĂƚĂƐƚŚŵĂŚĂǀĞƉĞƌƐŝƐƚĞŶƚ

ĂŝƌŇŽǁůŝŵŝƚĂƟŽŶ͘dŚĞĂŝŵŽĨƚŚŝƐƐƚƵĚLJǁĂƐƚŽĂƐƐĞƐƐƚŚĞƌĂƚĞŽĨůƵŶŐĨƵŶĐƟŽŶĚĞĐůŝŶĞŝŶ

ƉĂƟĞŶƚƐǁŝƚŚĚŝĸĐƵůƚͲƚŽͲƚƌĞĂƚĂƐƚŚŵĂĂŶĚƚŽŝĚĞŶƟĨLJƌŝƐŬĨĂĐƚŽƌƐŽĨĂĐĐĞůĞƌĂƚĞĚĚĞĐůŝŶĞŝŶ

ůƵŶŐĨƵŶĐƟŽŶ͘

ŚĂƉƚĞƌϳ͗/ŶƚŚŝƐĮŶĂůƐƚƵĚLJǁĞŝŶǀĞƐƟŐĂƚĞĚǁŚĞƚŚĞƌƚŚĞƐŽĐĂůůĞĚ͞ĞŽƐŝŶŽƉŚŝůŝĐƉŚĞŶŽƚLJƉĞ͕͟

ǁŚŝĐŚŚĂƐďĞĞŶĚĞƚĞƌŵŝŶĞĚŝŶĐƌŽƐƐͲƐĞĐƟŽŶĂůƐƚƵĚŝĞƐ͕ŝƐĂƉĞƌŵĂŶĞŶƚĮŶĚŝŶŐŽǀĞƌϱLJĞĂƌƐ

ĂŶĚĂƐƐĞƐƐĞĚǁŚĞƚŚĞƌƉĞƌŵĂŶĞŶƚƐƉƵƚƵŵĞŽƐŝŶŽƉŚŝůŝĂŝƐĂƐƐŽĐŝĂƚĞĚǁŝƚŚĐĞƌƚĂŝŶĐůŝŶŝĐĂůŽƌ

ŝŶŇĂŵŵĂƚŽƌLJĐŚĂƌĂĐƚĞƌŝƐƟĐƐ͘

ŚĂƉƚĞƌϴ͗ŝŶƚŚŝƐĐŚĂƉƚĞƌĚĂƚĂĨƌŽŵƚŚĞĚŝīĞƌĞŶƚƐƚƵĚŝĞƐĂƌĞƐƵŵŵĂƌŝnjĞĚĂŶĚƚŚĞŝŵƉůŝĐĂƟŽŶƐ

ĂƌĞĚŝƐĐƵƐƐĞĚĨƌŽŵĐůŝŶŝĐĂůŽƌƌĞƐĞĂƌĐŚƉĞƌƐƉĞĐƟǀĞƐ͘

(8)

ŚĂƉƚĞƌϭ

ϭϱ

Zϭ ZϮ Zϯ Zϰ Zϱ Zϲ Zϳ Zϴ Zϵ ZϭϬ Zϭϭ ZϭϮ Zϭϯ Zϭϰ Zϭϱ Zϭϲ Zϭϳ Zϭϴ Zϭϵ ZϮϬ ZϮϭ ZϮϮ ZϮϯ ZϮϰ ZϮϱ ZϮϲ ZϮϳ ZϮϴ ZϮϵ ZϯϬ Zϯϭ ZϯϮ Zϯϯ Zϯϰ Zϯϱ Zϯϲ Zϯϳ Zϯϴ

ZĞĨĞƌĞŶĐĞƐ

;ϭͿ WƌŽĐĞĞĚŝŶŐƐ ŽĨ ƚŚĞ d^ ǁŽƌŬƐŚŽƉ ŽŶ ƌĞĨƌĂĐƚŽƌLJ ĂƐƚŚŵĂ͗ ĐƵƌƌĞŶƚ ƵŶĚĞƌƐƚĂŶĚŝŶŐ͕

ƌĞĐŽŵŵĞŶĚĂƟŽŶƐ͕ĂŶĚƵŶĂŶƐǁĞƌĞĚƋƵĞƐƟŽŶƐ͘ŵĞƌŝĐĂŶdŚŽƌĂĐŝĐ^ŽĐŝĞƚLJ͘ŵ:ZĞƐƉŝƌƌŝƚ

ĂƌĞDĞĚϮϬϬϬĞĐ͖ϭϲϮ;ϲͿ͗ϮϯϰϭͲϱϭ͘

;ϮͿ ŚĂŶĞnjW͕tĞŶnjĞů^͕ŶĚĞƌƐŽŶ'W͕ŶƚŽ:D͕Ğů,͕ŽƵůĞƚ>W͕ĞƚĂů͘^ĞǀĞƌĞĂƐƚŚŵĂŝŶĂĚƵůƚƐ͗

ǁŚĂƚĂƌĞƚŚĞŝŵƉŽƌƚĂŶƚƋƵĞƐƟŽŶƐ͍:ůůĞƌŐLJůŝŶ/ŵŵƵŶŽůϮϬϬϳ:ƵŶ͖ϭϭϵ;ϲͿ͗ϭϯϯϳͲϰϴ͘

;ϯͿ ŚƵŶŐ<&͕'ŽĚĂƌĚW͕ĚĞůƌŽƚŚ͕LJƌĞƐ:͕ĂƌŶĞƐE͕ĂƌŶĞƐW͕ĞƚĂů͘ŝĸĐƵůƚͬƚŚĞƌĂƉLJͲƌĞƐŝƐƚĂŶƚ

ĂƐƚŚŵĂ͗ ƚŚĞ ŶĞĞĚ ĨŽƌ ĂŶ ŝŶƚĞŐƌĂƚĞĚ ĂƉƉƌŽĂĐŚ ƚŽ ĚĞĮŶĞ ĐůŝŶŝĐĂů ƉŚĞŶŽƚLJƉĞƐ͕ ĞǀĂůƵĂƚĞ ƌŝƐŬ

ĨĂĐƚŽƌƐ͕ ƵŶĚĞƌƐƚĂŶĚ ƉĂƚŚŽƉŚLJƐŝŽůŽŐLJ ĂŶĚ ĮŶĚ ŶŽǀĞů ƚŚĞƌĂƉŝĞƐ͘ Z^ dĂƐŬ &ŽƌĐĞ ŽŶ ŝĸĐƵůƚͬ

dŚĞƌĂƉLJͲZĞƐŝƐƚĂŶƚƐƚŚŵĂ͘ƵƌŽƉĞĂŶZĞƐƉŝƌĂƚŽƌLJ^ŽĐŝĞƚLJ͘ƵƌZĞƐƉŝƌ:ϭϵϵϵDĂLJ͖ϭϯ;ϱͿ͗ϭϭϵϴͲ ϮϬϴ͘

;ϰͿ ,ƵŵďĞƌƚD͕ĞĂƐůĞLJZ͕LJƌĞƐ:͕^ůĂǀŝŶZ͕,ĞďĞƌƚ:͕ŽƵƐƋƵĞƚ:͕ĞƚĂů͘ĞŶĞĮƚƐŽĨŽŵĂůŝnjƵŵĂď

ĂƐĂĚĚͲŽŶƚŚĞƌĂƉLJŝŶƉĂƟĞŶƚƐǁŝƚŚƐĞǀĞƌĞƉĞƌƐŝƐƚĞŶƚĂƐƚŚŵĂǁŚŽĂƌĞŝŶĂĚĞƋƵĂƚĞůLJĐŽŶƚƌŽůůĞĚ

ĚĞƐƉŝƚĞ ďĞƐƚ ĂǀĂŝůĂďůĞ ƚŚĞƌĂƉLJ ;'/E ϮϬϬϮ ƐƚĞƉ ϰ ƚƌĞĂƚŵĞŶƚͿ͗ /EEKsd͘ ůůĞƌŐLJ ϮϬϬϱ

DĂƌ͖ϲϬ;ϯͿ͗ϯϬϵͲϭϲ͘

;ϱͿ tĞŶnjĞů ^͘ ƐƚŚŵĂ͗ ĚĞĮŶŝŶŐ ŽĨ ƚŚĞ ƉĞƌƐŝƐƚĞŶƚ ĂĚƵůƚ ƉŚĞŶŽƚLJƉĞƐ͘ >ĂŶĐĞƚ ϮϬϬϲ ƵŐ

Ϯϲ͖ϯϲϴ;ϵϱϯϳͿ͗ϴϬϰͲϭϯ͘

;ϲͿ DŝƌĂŶĚĂ ͕ ƵƐĂĐŬĞƌ ͕ ĂůnjĂƌ ^͕ dƌƵĚĞĂƵ :͕ tĞŶnjĞů ^͘ ŝƐƟŶŐƵŝƐŚŝŶŐ ƐĞǀĞƌĞ ĂƐƚŚŵĂ

ƉŚĞŶŽƚLJƉĞƐ͗ƌŽůĞŽĨĂŐĞĂƚŽŶƐĞƚĂŶĚĞŽƐŝŶŽƉŚŝůŝĐŝŶŇĂŵŵĂƟŽŶ͘:ůůĞƌŐLJůŝŶ/ŵŵƵŶŽůϮϬϬϰ

:ĂŶ͖ϭϭϯ;ϭͿ͗ϭϬϭͲϴ͘

;ϳͿ ƚĞŶƌŝŶŬĞ͕^ƚĞƌŬW:͕DĂƐĐůĞĞ͕^ƉŝŶŚŽǀĞŶW͕^ĐŚŵŝĚƚ:d͕ǁŝŶĚĞƌŵĂŶ,͕ĞƚĂů͘ZŝƐŬĨĂĐƚŽƌƐ

ŽĨĨƌĞƋƵĞŶƚĞdžĂĐĞƌďĂƟŽŶƐŝŶĚŝĸĐƵůƚͲƚŽͲƚƌĞĂƚĂƐƚŚŵĂ͘ƵƌZĞƐƉŝƌ:ϮϬϬϱEŽǀ͖Ϯϲ;ϱͿ͗ϴϭϮͲϴ͘

;ϴͿ ƚĞŶƌŝŶŬĞ͕ǁŝŶĚĞƌŵĂŶ,͕^ƚĞƌŬW:͕ZĂďĞ<&͕Ğů,͘&ĂĐƚŽƌƐĂƐƐŽĐŝĂƚĞĚǁŝƚŚƉĞƌƐŝƐƚĞŶƚ

ĂŝƌŇŽǁůŝŵŝƚĂƟŽŶŝŶƐĞǀĞƌĞĂƐƚŚŵĂ͘ŵ:ZĞƐƉŝƌƌŝƚĂƌĞDĞĚϮϬϬϭ^ĞƉϭ͖ϭϲϰ;ϱͿ͗ϳϰϰͲϴ͘

;ϵͿ ƚĞŶ ƌŝŶŬĞ ͕ ǀĂŶ ŝƐƐĞů :d͕ ^ƚĞƌŬ W:͕ ǁŝŶĚĞƌŵĂŶ ,͕ ZĂďĞ <&͕ Ğů ,͘ WĞƌƐŝƐƚĞŶƚ ĂŝƌŇŽǁ

ůŝŵŝƚĂƟŽŶŝŶĂĚƵůƚͲŽŶƐĞƚŶŽŶĂƚŽƉŝĐĂƐƚŚŵĂŝƐĂƐƐŽĐŝĂƚĞĚǁŝƚŚƐĞƌŽůŽŐŝĐĞǀŝĚĞŶĐĞŽĨŚůĂŵLJĚŝĂ

ƉŶĞƵŵŽŶŝĂĞŝŶĨĞĐƟŽŶ͘:ůůĞƌŐLJůŝŶ/ŵŵƵŶŽůϮϬϬϭDĂƌ͖ϭϬϳ;ϯͿ͗ϰϰϵͲϱϰ͘

;ϭϬͿ ƵŵďĂĐĞĂ͕ĂŵƉďĞůů͕EŐƵLJĞŶ>͕Ăƌƌ͕ĂƌŶĞƐW:͕ZŽďŝŶƐŽŶ͕ĞƚĂů͘WĂƌĂŵĞƚĞƌƐĂƐƐŽĐŝĂƚĞĚ

ǁŝƚŚƉĞƌƐŝƐƚĞŶƚĂŝƌŇŽǁŽďƐƚƌƵĐƟŽŶŝŶĐŚƌŽŶŝĐƐĞǀĞƌĞĂƐƚŚŵĂ͘ƵƌZĞƐƉŝƌ:ϮϬϬϰ:Ƶů͖Ϯϰ;ϭͿ͗ϭϮϮͲϴ͘

;ϭϭͿ 'ŽůĚƐƚĞŝŶD&͕&ĂůůŽŶ::͕:ƌ͕͘,ĂƌŶŝŶŐZ͘ŚƌŽŶŝĐŐůƵĐŽĐŽƌƟĐŽŝĚƚŚĞƌĂƉLJͲŝŶĚƵĐĞĚŽƐƚĞŽƉŽƌŽƐŝƐŝŶ

ƉĂƟĞŶƚƐǁŝƚŚŽďƐƚƌƵĐƟǀĞůƵŶŐĚŝƐĞĂƐĞ͘ŚĞƐƚϭϵϵϵĞĐ͖ϭϭϲ;ϲͿ͗ϭϳϯϯͲϰϵ͘

;ϭϮͿ tĂůƚĞƌƐ :͕ tĂůƚĞƌƐ ,͕ tŽŽĚͲĂŬĞƌ Z͘ KƌĂů ĐŽƌƟĐŽƐƚĞƌŽŝĚƐ ĨŽƌ ƐƚĂďůĞ ĐŚƌŽŶŝĐ ŽďƐƚƌƵĐƟǀĞ

ƉƵůŵŽŶĂƌLJĚŝƐĞĂƐĞ͘ŽĐŚƌĂŶĞĂƚĂďĂƐĞ^LJƐƚZĞǀϮϬϬϱ͖;ϯͿ͗ϬϬϱϯϳϰ͘

;ϭϯͿ ƚĞŶ͘ZŝƐŬĨĂĐƚŽƌƐĂƐƐŽĐŝĂƚĞĚǁŝƚŚŝƌƌĞǀĞƌƐŝďůĞĂŝƌŇŽǁůŝŵŝƚĂƟŽŶŝŶĂƐƚŚŵĂ͘ƵƌƌKƉŝŶůůĞƌŐLJ

ůŝŶ/ŵŵƵŶŽůϮϬϬϴ&Ğď͖ϴ;ϭͿ͗ϲϯͲϵ͘

;ϭϰͿ sŝŐŶŽůĂD͕DŝƌĂďĞůůĂ&͕ŽƐƚĂŶnjŽ'͕ŝ'ŝŽƌŐŝZ͕'ũŽŵĂƌŬĂũD͕ĞůůŝĂs͕ĞƚĂů͘ŝƌǁĂLJƌĞŵŽĚĞůŝŶŐ

ŝŶĂƐƚŚŵĂ͘ŚĞƐƚϮϬϬϯDĂƌ͖ϭϮϯ;ϯ^ƵƉƉůͿ͗ϰϭϳ^ͲϮϮ^͘

(9)

ϭϲ

Zϭ ZϮ Zϯ Zϰ Zϱ Zϲ Zϳ Zϴ Zϵ ZϭϬ Zϭϭ ZϭϮ Zϭϯ Zϭϰ Zϭϱ Zϭϲ Zϭϳ Zϭϴ Zϭϵ ZϮϬ ZϮϭ ZϮϮ ZϮϯ ZϮϰ ZϮϱ ZϮϲ ZϮϳ ZϮϴ ZϮϵ ZϯϬ Zϯϭ ZϯϮ Zϯϯ Zϯϰ Zϯϱ Zϯϲ Zϯϳ Zϯϴ

;ϭϱͿ DĂƵĂĚd͕Ğů,͕^ƚĞƌŬW:͘ƐƚŚŵĂƚŚĞƌĂƉLJĂŶĚĂŝƌǁĂLJƌĞŵŽĚĞůŝŶŐ͘:ůůĞƌŐLJůŝŶ/ŵŵƵŶŽůϮϬϬϳ

EŽǀ͖ϭϮϬ;ϱͿ͗ϵϵϳͲϭϬϬϵ͘

;ϭϲͿ ,ŽůŐĂƚĞ^d͕,ŽůůŽǁĂLJ:͕tŝůƐŽŶ^͕,ŽǁĂƌƚŚW,͕,ĂŝƚĐŚŝ,D͕ĂďƵ^͕ĞƚĂů͘hŶĚĞƌƐƚĂŶĚŝŶŐƚŚĞ

ƉĂƚŚŽƉŚLJƐŝŽůŽŐLJŽĨƐĞǀĞƌĞĂƐƚŚŵĂƚŽŐĞŶĞƌĂƚĞŶĞǁƚŚĞƌĂƉĞƵƟĐŽƉƉŽƌƚƵŶŝƟĞƐ͘:ůůĞƌŐLJůŝŶ

/ŵŵƵŶŽůϮϬϬϲDĂƌ͖ϭϭϳ;ϯͿ͗ϰϵϲͲϱϬϲ͘

;ϭϳͿ >ĂŶŐĞ W͕ WĂƌŶĞƌ :͕ sĞƐƚďŽ :͕ ^ĐŚŶŽŚƌ W͕ :ĞŶƐĞŶ '͘  ϭϱͲLJĞĂƌ ĨŽůůŽǁͲƵƉ ƐƚƵĚLJ ŽĨ ǀĞŶƟůĂƚŽƌLJ

ĨƵŶĐƟŽŶŝŶĂĚƵůƚƐǁŝƚŚĂƐƚŚŵĂ͘EŶŐů:DĞĚϭϵϵϴKĐƚϮϮ͖ϯϯϵ͗ϭϭϵϰͲϮϬϬ͘

;ϭϴͿ ǀĂŶZĞŶƐĞŶ>͕^ŽŶƚ:<͕ǀĞƌƚƐĞ͕tŝůůĞŵƐ>E͕DĂƵĂĚd͕,ŝĞŵƐƚƌĂW^͕ĞƚĂů͘ƌŽŶĐŚŝĂůϴĐĞůů

ŝŶĮůƚƌĂƚĞĂŶĚůƵŶŐĨƵŶĐƟŽŶĚĞĐůŝŶĞŝŶĂƐƚŚŵĂ͘ŵ:ZĞƐƉŝƌƌŝƚĂƌĞDĞĚϮϬϬϱKĐƚϭ͖ϭϳϮ;ϳͿ͗ϴϯϳͲ ϰϭ͘

;ϭϵͿ ĂƌƌĞůůZt͕>ŽŵĂƐ͘ůƉŚĂϭͲĂŶƟƚƌLJƉƐŝŶĚĞĮĐŝĞŶĐLJͲͲĂŵŽĚĞůĨŽƌĐŽŶĨŽƌŵĂƟŽŶĂůĚŝƐĞĂƐĞƐ͘E

ŶŐů:DĞĚϮϬϬϮ:ĂŶϯ͖ϯϰϲ;ϭͿ͗ϰϱͲϱϯ͘

;ϮϬͿ ^ŝŐƐŐĂĂƌĚd͕ƌĂŶĚƐůƵŶĚ/͕KŵůĂŶĚK͕,ũŽƌƚ͕>ƵŶĚ͕WĞĚĞƌƐĞŶK&͕ĞƚĂů͘^ĂŶĚĂůƉŚĂϭͲ ĂŶƟƚƌLJƉƐŝŶ ĂůůĞůĞƐ ĂƌĞ ƌŝƐŬ ĨĂĐƚŽƌƐ ĨŽƌ ďƌŽŶĐŚŝĂů ŚLJƉĞƌƌĞƐƉŽŶƐŝǀĞŶĞƐƐ ŝŶ LJŽƵŶŐ ĨĂƌŵĞƌƐ͗ ĂŶ

ĞdžĂŵƉůĞŽĨŐĞŶĞͬĞŶǀŝƌŽŶŵĞŶƚŝŶƚĞƌĂĐƟŽŶ͘ƵƌZĞƐƉŝƌ:ϮϬϬϬ:Ƶů͖ϭϲ;ϭͿ͗ϱϬͲϱ͘

;ϮϭͿ ĂƌƌŽůůE͕ŽŽŬĞ͕:ĂŵĞƐ͘dŚĞĚŝƐƚƌŝďƵƟŽŶŽĨĞŽƐŝŶŽƉŚŝůƐĂŶĚůLJŵƉŚŽĐLJƚĞƐŝŶƚŚĞůĂƌŐĞĂŶĚ

ƐŵĂůůĂŝƌǁĂLJƐŽĨĂƐƚŚŵĂƟĐƐ͘ƵƌZĞƐƉŝƌ:ϭϵϵϳ&Ğď͖ϭϬ͗ϮϵϮͲϯϬϬ͘

;ϮϮͿ DĂƵĂĚd͕^ŝůǀĂ>&͕^ĂŶƚŽƐD͕'ƌŝŶďĞƌŐ>͕ĞƌŶĂƌĚŝ&͕DĂƌƟŶƐD͕ĞƚĂů͘ďŶŽƌŵĂůĂůǀĞŽůĂƌ

ĂƩĂĐŚŵĞŶƚƐǁŝƚŚĚĞĐƌĞĂƐĞĚĞůĂƐƟĐĮďĞƌĐŽŶƚĞŶƚŝŶĚŝƐƚĂůůƵŶŐŝŶĨĂƚĂůĂƐƚŚŵĂ͘ŵ:ZĞƐƉŝƌƌŝƚ

ĂƌĞDĞĚϮϬϬϰKĐƚϭϱ͖ϭϳϬ;ϴͿ͗ϴϱϳͲϲϮ͘

;ϮϯͿ ,ĂŵŝĚY͕^ŽŶŐz͕<ŽƚƐŝŵďŽƐd͕DŝŶƐŚĂůů͕ĂŝdZ͕,ĞŐĞůĞZ'͕ĞƚĂů͘/ŶŇĂŵŵĂƟŽŶŽĨƐŵĂůů

ĂŝƌǁĂLJƐŝŶĂƐƚŚŵĂ͘:ůůĞƌŐLJůŝŶ/ŵŵƵŶŽůϭϵϵϳ:Ƶů͖ϭϬϬ͗ϰϰͲϱϭ͘

;ϮϰͿ ,ĂƵďĞƌ,W͕'ŽƞƌŝĞĚD͕EĞǁŵĂŶ<͕ĂŶĚĂZ͕^ĞƌǀŝZ:͕ŚƌŝƐƚŽĚŽƵůŽƉŽƵůŽƐW͕ĞƚĂů͘īĞĐƚŽĨ

,&ͲŇƵŶŝƐŽůŝĚĞŽŶƉĞƌŝƉŚĞƌĂůůƵŶŐŝŶŇĂŵŵĂƟŽŶŝŶĂƐƚŚŵĂ͘:ůůĞƌŐLJůŝŶ/ŵŵƵŶŽůϮϬϬϯ:Ƶů

͖ϭϭϮ;ϭͿ͗ϱϴͲϲϯ͘

;ϮϱͿ <ƌĂŌD͕ũƵŬĂŶŽǀŝĐZ͕tŝůƐŽŶ^͕,ŽůŐĂƚĞ^d͕DĂƌƟŶZ:͘ůǀĞŽůĂƌƟƐƐƵĞŝŶŇĂŵŵĂƟŽŶŝŶĂƐƚŚŵĂ͘

ŵ:ZĞƐƉŝƌƌŝƚĂƌĞDĞĚϭϵϵϲEŽǀ͖ϭϱϰ͗ϭϱϬϱͲϭϬ͘

;ϮϲͿ ŝŶ ͚ƚ sĞĞŶ͕ ĞĞŬŵĂŶ :͕ Ğů ,͕ ^ƚĞƌŬ W:͘ ZĞĐƵƌƌĞŶƚ ĞdžĂĐĞƌďĂƟŽŶƐ ŝŶ ƐĞǀĞƌĞ ĂƐƚŚŵĂ ĂƌĞ

ĂƐƐŽĐŝĂƚĞĚǁŝƚŚĞŶŚĂŶĐĞĚĂŝƌǁĂLJĐůŽƐƵƌĞĚƵƌŝŶŐƐƚĂďůĞĞƉŝƐŽĚĞƐ͘ŵ:ZĞƐƉŝƌƌŝƚĂƌĞDĞĚ

ϮϬϬϬ:ƵŶ͖ϭϲϭ;ϲͿ͗ϭϵϬϮͲϲ͘

;ϮϳͿ ƚĞŶ ƌŝŶŬĞ ͕ ǁŝŶĚĞƌŵĂŶ ,͕ ^ƚĞƌŬ W:͕ ZĂďĞ <&͕ Ğů ,͘ ͞ZĞĨƌĂĐƚŽƌLJ͟ ĞŽƐŝŶŽƉŚŝůŝĐ ĂŝƌǁĂLJ

ŝŶŇĂŵŵĂƟŽŶŝŶƐĞǀĞƌĞĂƐƚŚŵĂ͗ĞīĞĐƚŽĨƉĂƌĞŶƚĞƌĂůĐŽƌƟĐŽƐƚĞƌŽŝĚƐ͘ŵ:ZĞƐƉŝƌƌŝƚĂƌĞDĞĚ

ϮϬϬϰ^ĞƉϭϱ͖ϭϳϬ;ϲͿ͗ϲϬϭͲϱ͘

;ϮϴͿ 'ŝďďŽŶƐt:͕^ŚĂƌŵĂ͕>ŽƵŐŚĞĞĚ͕DĂĐŬůĞŵWd͘ĞƚĞĐƟŽŶŽĨĞdžĐĞƐƐŝǀĞďƌŽŶĐŚŽĐŽŶƐƚƌŝĐƟŽŶ

ŝŶĂƐƚŚŵĂ͘ŵ:ZĞƐƉŝƌƌŝƚĂƌĞDĞĚϭϵϵϲ&Ğď͖ϭϱϯ͗ϱϴϮͲϵ͘

;ϮϵͿ ^ŚŽƌĞ ^͘ KďĞƐŝƚLJ ĂŶĚ ĂƐƚŚŵĂ͗ ƉŽƐƐŝďůĞ ŵĞĐŚĂŶŝƐŵƐ͘ : ůůĞƌŐLJ ůŝŶ /ŵŵƵŶŽů ϮϬϬϴ

DĂLJ͖ϭϮϭ;ϱͿ͗ϭϬϴϳͲϵϯ͘

(10)

ŚĂƉƚĞƌϭ

ϭϳ

Zϭ ZϮ Zϯ Zϰ Zϱ Zϲ Zϳ Zϴ Zϵ ZϭϬ Zϭϭ ZϭϮ Zϭϯ Zϭϰ Zϭϱ Zϭϲ Zϭϳ Zϭϴ Zϭϵ ZϮϬ ZϮϭ ZϮϮ ZϮϯ ZϮϰ ZϮϱ ZϮϲ ZϮϳ ZϮϴ ZϮϵ ZϯϬ Zϯϭ ZϯϮ Zϯϯ Zϯϰ Zϯϱ Zϯϲ Zϯϳ Zϯϴ

;ϯϬͿ WĂƐƚĞƌŶĂĐŬZ͕,ƵŚƚĂůĂ,͕<ĂƌũĂůĂŝŶĞŶ:͘ŚůĂŵLJĚŽƉŚŝůĂ;ŚůĂŵLJĚŝĂͿƉŶĞƵŵŽŶŝĂĞƐĞƌŽůŽŐLJĂŶĚ

ĂƐƚŚŵĂŝŶĂĚƵůƚƐ͗ĂůŽŶŐŝƚƵĚŝŶĂůĂŶĂůLJƐŝƐ͘:ůůĞƌŐLJůŝŶ/ŵŵƵŶŽůϮϬϬϱEŽǀ͖ϭϭϲ;ϱͿ͗ϭϭϮϯͲϴ͘

;ϯϭͿ ĂŝdZ͕sŽŶŬ:D͕WŽƐƚŵĂ^͕ŽĞnjĞŶ,D͘^ĞǀĞƌĞĞdžĂĐĞƌďĂƟŽŶƐƉƌĞĚŝĐƚĞdžĐĞƐƐůƵŶŐĨƵŶĐƟŽŶ

ĚĞĐůŝŶĞŝŶĂƐƚŚŵĂ͘ƵƌZĞƐƉŝƌ:ϮϬϬϳ^ĞƉ͖ϯϬ;ϯͿ͗ϰϱϮͲϲ͘

;ϯϮͿ K͛LJƌŶĞWD͕WĞĚĞƌƐĞŶ^͕>Ăŵŵ:͕dĂŶt͕ƵƐƐĞtt͘^ĞǀĞƌĞĞdžĂĐĞƌďĂƟŽŶƐĂŶĚĚĞĐůŝŶĞŝŶ

ůƵŶŐĨƵŶĐƟŽŶŝŶĂƐƚŚŵĂ͘ŵ:ZĞƐƉŝƌƌŝƚĂƌĞDĞĚϮϬϬϵ:ĂŶϭ͖ϭϳϵ;ϭͿ͗ϭϵͲϮϰ͘

;ϯϯͿ ĞƌƌLJD͕DŽƌŐĂŶ͕^ŚĂǁ͕WĂƌŬĞƌ͕'ƌĞĞŶZ͕ƌŝŐŚƚůŝŶŐ͕ĞƚĂů͘WĂƚŚŽůŽŐŝĐĂůĨĞĂƚƵƌĞƐĂŶĚ

ŝŶŚĂůĞĚ ĐŽƌƟĐŽƐƚĞƌŽŝĚ ƌĞƐƉŽŶƐĞ ŽĨ ĞŽƐŝŶŽƉŚŝůŝĐ ĂŶĚ ŶŽŶͲĞŽƐŝŶŽƉŚŝůŝĐ ĂƐƚŚŵĂ͘ dŚŽƌĂdž ϮϬϬϳ

ĞĐ͖ϲϮ;ϭϮͿ͗ϭϬϰϯͲϵ͘

;ϯϰͿ ŽƵǁĞƐ:͕'ŝďƐŽŶW͕WĞŬŬĂŶĞŶ:͕WĞĂƌĐĞE͘EŽŶͲĞŽƐŝŶŽƉŚŝůŝĐĂƐƚŚŵĂ͗ŝŵƉŽƌƚĂŶĐĞĂŶĚƉŽƐƐŝďůĞ

ŵĞĐŚĂŶŝƐŵƐ͘dŚŽƌĂdžϮϬϬϮ:Ƶů͖ϱϳ;ϳͿ͗ϲϰϯͲϴ͘

;ϯϱͿ >ĞŵŝĞƌĞ ͕ ƌŶƐƚ W͕ KůŝǀĞŶƐƚĞŝŶ Z͕ zĂŵĂƵĐŚŝ z͕ 'ŽǀŝŶĚĂƌĂũƵ <͕ >ƵĚǁŝŐ D^͕ Ğƚ Ăů͘ ŝƌǁĂLJ

ŝŶŇĂŵŵĂƟŽŶĂƐƐĞƐƐĞĚďLJŝŶǀĂƐŝǀĞĂŶĚŶŽŶŝŶǀĂƐŝǀĞŵĞĂŶƐŝŶƐĞǀĞƌĞĂƐƚŚŵĂ͗ĞŽƐŝŶŽƉŚŝůŝĐĂŶĚ

ŶŽŶĞŽƐŝŶŽƉŚŝůŝĐƉŚĞŶŽƚLJƉĞƐ͘:ůůĞƌŐLJůŝŶ/ŵŵƵŶŽůϮϬϬϲEŽǀ͖ϭϭϴ;ϱͿ͗ϭϬϯϯͲϵ͘

;ϯϲͿ tĞŶnjĞů^͕^ĐŚǁĂƌƚnj>͕>ĂŶŐŵĂĐŬ>͕,ĂůůŝĚĂLJ:>͕dƌƵĚĞĂƵ:͕'ŝďďƐZ>͕ĞƚĂů͘ǀŝĚĞŶĐĞƚŚĂƚ

ƐĞǀĞƌĞ ĂƐƚŚŵĂ ĐĂŶ ďĞ ĚŝǀŝĚĞĚ ƉĂƚŚŽůŽŐŝĐĂůůLJ ŝŶƚŽ ƚǁŽ ŝŶŇĂŵŵĂƚŽƌLJ ƐƵďƚLJƉĞƐ ǁŝƚŚ ĚŝƐƟŶĐƚ

ƉŚLJƐŝŽůŽŐŝĐĂŶĚĐůŝŶŝĐĂůĐŚĂƌĂĐƚĞƌŝƐƟĐƐ͘ŵ:ZĞƐƉŝƌƌŝƚĂƌĞDĞĚϭϵϵϵ^ĞƉ͖ϭϲϬ͗ϭϬϬϭͲϴ͘

;ϯϳͿ WĂƐĐƵĂůZD͕WĞƚĞƌƐ^W͘ŝƌǁĂLJƌĞŵŽĚĞůŝŶŐĐŽŶƚƌŝďƵƚĞƐƚŽƚŚĞƉƌŽŐƌĞƐƐŝǀĞůŽƐƐŽĨůƵŶŐĨƵŶĐƟŽŶ

ŝŶĂƐƚŚŵĂ͗ĂŶŽǀĞƌǀŝĞǁ͘:ůůĞƌŐLJůŝŶ/ŵŵƵŶŽůϮϬϬϱ^ĞƉ͖ϭϭϲ;ϯͿ͗ϰϳϳͲϴϲ͘

;ϯϴͿ dƵůŝĐD<͕,ĂŵŝĚY͘ŽŶƚƌŝďƵƟŽŶŽĨƚŚĞĚŝƐƚĂůůƵŶŐƚŽƚŚĞƉĂƚŚŽůŽŐŝĐĂŶĚƉŚLJƐŝŽůŽŐŝĐĐŚĂŶŐĞƐ

ŝŶ ĂƐƚŚŵĂ͗ ƉŽƚĞŶƟĂů ƚŚĞƌĂƉĞƵƟĐ ƚĂƌŐĞƚ ZŽŐĞƌ ^͘ DŝƚĐŚĞůů ůĞĐƚƵƌĞ͘ ŚĞƐƚ ϮϬϬϯ DĂƌ͖ϭϮϯ;ϯ

^ƵƉƉůͿ͗ϯϰϴ^Ͳϱϱ^͘

;ϯϵͿ ĞƌŐĞƌŽŶ͕,ĂƵďĞƌ,W͕'ŽƞƌŝĞĚD͕EĞǁŵĂŶ<͕ŚĂŶĚĂZ͕^ĞƌǀŝZ:͕ĞƚĂů͘ǀŝĚĞŶĐĞŽĨƌĞŵŽĚĞůŝŶŐ

ŝŶƉĞƌŝƉŚĞƌĂůĂŝƌǁĂLJƐŽĨƉĂƟĞŶƚƐǁŝƚŚŵŝůĚƚŽŵŽĚĞƌĂƚĞĂƐƚŚŵĂ͗ĞīĞĐƚŽĨŚLJĚƌŽŇƵŽƌŽĂůŬĂŶĞͲ ŇƵŶŝƐŽůŝĚĞ͘:ůůĞƌŐLJůŝŶ/ŵŵƵŶŽůϮϬϬϱEŽǀ͖ϭϭϲ;ϱͿ͗ϵϴϯͲϵ͘

;ϰϬͿ dŽŵůŝŶƐŽŶ:͕DĐDĂŚŽŶ͕ŚĂƵĚŚƵƌŝZ͕dŚŽŵƉƐŽŶ:D͕tŽŽĚ^&͕dŚŽŵƐŽŶE͘ĸĐĂĐLJŽĨ

ůŽǁĂŶĚŚŝŐŚĚŽƐĞŝŶŚĂůĞĚĐŽƌƟĐŽƐƚĞƌŽŝĚŝŶƐŵŽŬĞƌƐǀĞƌƐƵƐŶŽŶͲƐŵŽŬĞƌƐǁŝƚŚŵŝůĚĂƐƚŚŵĂ͘

dŚŽƌĂdžϮϬϬϱƉƌ͖ϲϬ;ϰͿ͗ϮϴϮͲϳ͘

(11)

ϭϴ

Zϭ ZϮ Zϯ Zϰ Zϱ Zϲ Zϳ Zϴ Zϵ ZϭϬ Zϭϭ ZϭϮ Zϭϯ Zϭϰ Zϭϱ Zϭϲ Zϭϳ Zϭϴ Zϭϵ ZϮϬ ZϮϭ ZϮϮ ZϮϯ ZϮϰ ZϮϱ ZϮϲ ZϮϳ ZϮϴ ZϮϵ ZϯϬ Zϯϭ ZϯϮ Zϯϯ Zϯϰ Zϯϱ Zϯϲ Zϯϳ Zϯϴ

Referenties

GERELATEERDE DOCUMENTEN

17 The approach identi fies patients who are currently not controlled, systematically addresses potentially preventable or treatable factors and distinguishes those with

Studies meeting the following criteria were included in this review: (a) participants were patients with DA as defi ned by the ERS task force [26], or were patients with asthma in

We aimed to identify characteristics of the concept of difficult-to-treat RA and to explore issues to be addressed in its workup and management that are not covered by current

Alternatively, if the standard errors (SEs) of the survival probabilities of the treated and control group are given, confidence intervals can be estimated using

Het bijwonen van de promotie is gezien het aantal beschikbare plaatsen alleen mogelijk op vertoon van een toegangsbewijs. Dit toegangsbewijs kan worden aangevraagd bij

dŚĞ ƉƵďůŝĐĂƟŽŶ ŽĨ ƚŚŝƐ ƚŚĞƐŝƐ ǁĂƐ ĮŶĂŶĐŝĂůůLJ ƐƵƉƉŽƌƚĞĚ ďLJ͗ ZĂĂĚ ǀĂŶ ĞƐƚƵƵƌ

Zϭ ZϮ Zϯ Zϰ Zϱ Zϲ Zϳ Zϴ Zϵ ZϭϬ Zϭϭ ZϭϮ Zϭϯ Zϭϰ Zϭϱ Zϭϲ Zϭϳ Zϭϴ Zϭϵ ZϮϬ ZϮϭ ZϮϮ ZϮϯ ZϮϰ ZϮϱ ZϮϲ ZϮϳ ZϮϴ ZϮϵ ZϯϬ Zϯϭ ZϯϮ Zϯϯ Zϯϰ Zϯϱ Zϯϲ

Overgewicht bij patiënten met astma gaat niet gepaard met een toename van inflammatie in de luchtwegen maar verhoogt wel het risico op moeilijk behandelbaar astma (dit