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Difficult-to-treat asthma : mechanisms and risk factors Veen, H.P.A.A. van

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Difficult-to-treat asthma : mechanisms and risk factors

Veen, H.P.A.A. van

Citation

Veen, H. P. A. A. van. (2010, September 2). Difficult-to-treat asthma : mechanisms and risk factors. Retrieved from

https://hdl.handle.net/1887/15918

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden

Downloaded from: https://hdl.handle.net/1887/15918

Note: To cite this publication please use the final published version (if applicable).

(2)

ŝĸĐƵůƚͲƚŽͲƚƌĞĂƚĂƐƚŚŵĂ

ŵĞĐŚĂŶŝƐŵƐĂŶĚƌŝƐŬĨĂĐƚŽƌƐ

/ůŽŶŬĂǀĂŶsĞĞŶ

(3)

/^E͗ϵϳϴͲϵϰͲϲϭϬϴͲϬϱϲͲϭ

ŽǀĞƌ͗͞sĂƌŝĂƟŽŶ͗ƚŚĞďĞĂƵƚLJŽĨůŝĨĞ͟;ĚĞƐŝŐŶ͗DĂƌŝũŬĞΛǀŽƌŵŐĞĞǀĞ͘ŶůͿ

>ĂLJŽƵƚĂŶĚƉƌŝŶƚĞĚďLJ'ŝůĚĞƉƌŝŶƚƌƵŬŬĞƌŝũĞŶͲŶƐĐŚĞĚĞ͕ƚŚĞEĞƚŚĞƌůĂŶĚƐ dŚŝƐƚŚĞƐŝƐǁĂƐƐƵƉƉŽƌƚĞĚďLJĂŶƵŶƌĞƐƚƌŝĐƚĞĚĞĚƵĐĂƟŽŶĂůŐƌĂŶƚĨƌŽŵƐƚƌĂĞŶĞĐĂ

dŚĞ ƉƵďůŝĐĂƟŽŶ ŽĨ ƚŚŝƐ ƚŚĞƐŝƐ ǁĂƐ ĮŶĂŶĐŝĂůůLJ ƐƵƉƉŽƌƚĞĚ ďLJ͗ ZĂĂĚ ǀĂŶ ĞƐƚƵƵƌ DĞĚŝƐĐŚ

^ƉĞĐƚƌƵŵdǁĞŶƚĞŶƐĐŚĞĚĞ͕ƐƚƌĂĞŶĞĐĂ͕ŚŝĞƐŝ͕'ůĂdžŽ^ŵŝƚŚ<ůŝŶĞ͕EŽǀĂƌƟƐ

(4)

ŝĸĐƵůƚͲƚŽͲƚƌĞĂƚĂƐƚŚŵĂ

ŵĞĐŚĂŶŝƐŵƐĂŶĚƌŝƐŬĨĂĐƚŽƌƐ

WƌŽĞĨƐĐŚƌŝŌ

ƚĞƌǀĞƌŬƌŝũŐŝŶŐǀĂŶ

ĚĞŐƌĂĂĚǀĂŶŽĐƚŽƌĂĂŶĚĞhŶŝǀĞƌƐŝƚĞŝƚ>ĞŝĚĞŶ͕

ŽƉŐĞnjĂŐǀĂŶĚĞZĞĐƚŽƌDĂŐŶŝĮĐƵƐWƌŽĨ͘Dƌ͘W͘&͘ǀĂŶĚĞƌ,ĞŝũĚĞŶ͕

ǀŽůŐĞŶƐďĞƐůƵŝƚǀĂŶŚĞƚŽůůĞŐĞǀŽŽƌWƌŽŵŽƟĞƐ ƚĞǀĞƌĚĞĚŝŐĞŶŽƉ

ĚŽŶĚĞƌĚĂŐϮƐĞƉƚĞŵďĞƌϮϬϭϬ ŬůŽŬŬĞϭϱ͘ϬϬƵƵƌ

ĚŽŽƌ

,ĞůĞŶĂWĞƚƌŽŶĞůůĂŐĂƚŚĂŶƚŚŽŶŝĂǀĂŶsĞĞŶ

ŐĞďŽƌĞŶƚĞZĞĞƵǁŝũŬ

ŝŶϭϵϳϬ

(5)

WƌŽŵŽƟĞĐŽŵŵŝƐƐŝĞ

WƌŽŵŽƚŽƌĞƐ

WƌŽĨ͘ƌ͘<͘&͘ZĂďĞ

WƌŽĨ͘ƌ͘͘,͘Ğů;D͕ŵƐƚĞƌĚĂŵͿ KǀĞƌŝŐĞůĞĚĞŶ

ƌ͘͘ƚĞŶƌŝŶŬĞ;D>͕>ĞĞƵǁĂƌĚĞŶͿ

WƌŽĨ͘ƌ͘'͘&͘:ŽŽƐ;hŶŝǀĞƌƐŝƚĂŝƌŝĞŬĞŶŚƵŝƐ'ĞŶƚ͕ĞůŐŝ̘Ϳ WƌŽĨ͘ƌ͘W͘^͘,ŝĞŵƐƚƌĂ

WƌŽĨ͘ƌ͘&͘Z͘ZŽƐĞŶĚĂĂů

ƌ͘:͘<͘^ŽŶƚ

WƌŽĨ͘ƌ͘W͘:͘^ƚĞƌŬ;D͕ŵƐƚĞƌĚĂŵͿ

(6)

/ŬŐĞůŽŽĨ sƌĂĂŐŶŝĞƚŝŶǁĂƚ DĂĂƌŝŬŐĞůŽŽĨ /ŶĚĞnjĞĚĂŐ /ŬŐĞůŽŽĨ

sƌĂĂŐŶŝĞƚŝŶǁŝĞ DĂĂƌŝŬŐĞůŽŽĨ

tĂƚŝŬŚŝĞƌnjŝĞ /ŬŐĞůŽŽĨ

/ŶǁĂƚŝŬnjŝĞ

;^ƚĞĨŽƐ͕ŽŶĚĂŐŝŶ^ŽǁĞƚŽͿ

(7)
(8)

ŽŶƚĞŶƚƐ

ŚĂƉƚĞƌϭ 'ĞŶĞƌĂů/ŶƚƌŽĚƵĐƟŽŶ ϵ

 

ŚĂƉƚĞƌϮ ŝĸĐƵůƚͲƚŽͲƚƌĞĂƚĂƐƚŚŵĂ ϭϵ

ŚĂƉƚĞƌϯ ĞĮĐŝĞŶƚĂůƉŚĂͲϭͲĂŶƟƚƌLJƉƐŝŶƉŚĞŶŽƚLJƉĞƐĂŶĚ

 ƉĞƌƐŝƐƚĞŶƚĂŝƌŇŽǁůŝŵŝƚĂƟŽŶŝŶƐĞǀĞƌĞĂƐƚŚŵĂ ϰϵ

ŚĂƉƚĞƌϰ ůǀĞŽůĂƌŶŝƚƌŝĐŽdžŝĚĞǀĞƌƐƵƐŵĞĂƐƵƌĞƐŽĨƉĞƌŝƉŚĞƌĂů

 ĂŝƌǁĂLJĚLJƐĨƵŶĐƟŽŶŝŶƐĞǀĞƌĞĂƐƚŚŵĂ ϲϭ

ŚĂƉƚĞƌϱ ŝƌǁĂLJŝŶŇĂŵŵĂƟŽŶŝŶŽďĞƐĞĂŶĚŶŽŶͲŽďĞƐĞ

 ƉĂƟĞŶƚƐǁŝƚŚĚŝĸĐƵůƚͲƚŽͲƚƌĞĂƚĂƐƚŚŵĂ ϳϳ

ŚĂƉƚĞƌϲ džŚĂůĞĚŶŝƚƌŝĐŽdžŝĚĞƉƌĞĚŝĐƚƐůƵŶŐĨƵŶĐƟŽŶĚĞĐůŝŶĞŝŶ

 ĚŝĸĐƵůƚͲƚŽͲƚƌĞĂƚĂƐƚŚŵĂ ϵϭ

ŚĂƉƚĞƌϳ ŽŶƐŝƐƚĞŶĐLJŽĨƐƉƵƚƵŵĞŽƐŝŶŽƉŚŝůŝĂŝŶƉĂƟĞŶƚƐǁŝƚŚ

 ĚŝĸĐƵůƚͲƚŽͲƚƌĞĂƚĂƐƚŚŵĂ͗ĂϱͲLJĞĂƌĨŽůůŽǁͲƵƉƐƚƵĚLJ ϭϬϳ

ŚĂƉƚĞƌϴ ^ƵŵŵĂƌLJĂŶĚ'ĞŶĞƌĂůŝƐĐƵƐƐŝŽŶ ϭϮϭ

ŚĂƉƚĞƌϵ EĞĚĞƌůĂŶĚƐĞ^ĂŵĞŶǀĂƫŶŐ ϭϰϱ

ĂŶŬǁŽŽƌĚ  ϭϱϱ

ƵƌƌŝĐƵůƵŵsŝƚĂĞ  ϭϱϳ

(9)

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