Regulation and modulation of growth : insights from human and animal studies
Gool, S.A.van
Citation
Gool, S. Avan. (2011, May 18). Regulation and modulation of growth : insights from human and animal studies. Retrieved from
https://hdl.handle.net/1887/17645
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden Downloaded from: https://hdl.handle.net/1887/17645
Note: To cite this publication please use the final published version (if
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Regulation and modulation of growth Insights from human and animal studies
Sandy A. van Gool
The studies presented in this thesis were financially supported by the Netherlands Organization for Health Research and Development (ZonMW, grant 920-03-392), and by a grant from the European Society for Pediatric Endocrinology-Research Unit.
For publication of this thesis financial support from the Department of Pediatrics of the Leiden University Medical Center, the J.E. Jurriaanse Foundation, the “Nederlandse Vereniging voor Calcium- en Botstofwisseling’ (NVCB), Eli Lilly Nederland B.V., Ferring Pharmaceuticals, Ipsen Farmaceutica B.V., Novo Nordisk B.V., and Pfizer B.V., is gratefully acknowledged.
Graphic design: S.L. van Straten.
Cover: Superhero-team, I-stock images.
Printed by: GVO drukkers | Ponsen & Looijen.
ISBN: 978-90-6464-399-6
© 2010 S.A. van Gool, Hoofddorp, the Netherlands.
All rights reserved. No part of this publication may be reproduced in any form or by any means without prior permission of the author.
Regulation and modulation of growth Insights from human and animal studies
Proefschrift ter verkrijging van
de graad van Doctor aan de Universiteit Leiden
op gezag van de Rector Magnificus prof. mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op donderdag 2 december 2010 klokke 16:15 uur
door
Sandy Agathe van Gool geboren te Uitgeest
in 1974
Promotiecommissie
Promotor: Prof. dr. J.M. Wit
Co-promotores: Dr. H.B.J. Karperien (Universiteit Twente) Dr. W. Oostdijk
Overige leden: Prof. dr. H.A. Delemarre-van de Waal Prof. dr. J.C. van Houwelingen Prof. dr. M. Breuning
Dr. B.C.J. van der Eerden (Erasmus Universiteit Rotterdam)
A man’s reach should extend his grasp, or what’s a heaven for?
Robert Browning, 1855
Table of contents
Chapter 1 General introduction
Part A Clinical trials with growth hormone in children with ISS
Chapter 2 High dose growth hormone treatment limited to the prepubertal period in young children with idiopathic short stature does not increase adult height
European Journal of Endocrinology 2010;162(4): 653-660
Chapter 3 Final height outcome following 3 years of growth hormone and gonadotropin releasing hormone agonist treatment in short adolescents with relatively early puberty
The Journal of Clinical Endocrinology and Metabolism 2007;92(4):1402-1408
Part B Animal studies on the effect of aromatase inhibition
Chapter 4 Marginal growth increase, altered bone quality and polycystic ovaries in female prepubertal rats after treatment with the aromatase inhibitor exemestane
Hormone Research in Paediatrics 2010;73(1):49-60
Chapter 5 Impaired body weight and tail length gain and altered bone quality after treatment with the aromatase inhibitor exemestane in prepubertal male rats
Hormone Research in Paediatrics 2010;73(5):376-385 Part C An alternative model for growth studies
Chapter 6 Human fetal mesenchymal stem cells differentiating towards chondrocytes display a similar gene expression profile as growth plate cartilage
Submitted for publication
9
43
63
85
111
135
Chapter 7 General discussion Chapter 8 Summary
Chapter 9 Samenvatting Curriculum Vitae
List of publications List of abbreviations
171 185 191 197 201 205
