Refinement of antisense oligonucleotide mediated exon skipping as therapy for Duchenne muscular dystrophy
Heemskerk, J.A.
Citation
Heemskerk, J. A. (2011, October 26). Refinement of antisense
oligonucleotide mediated exon skipping as therapy for Duchenne muscular dystrophy. Retrieved from https://hdl.handle.net/1887/17986
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/17986
Note: To cite this publication please use the final published version (if
applicable).
Chapter 4 Pre-clinical PK and PD studies on 2’O- methyl-phosphorothioate RNA antisense oligonucleotides in the mdx mouse model
Heemskerk H
1, de Winter CL
1, van Kuik-Romeijn P
2, Heuvelmans N
2, Sabatelli P
3,4, Rimessi P
3, Braghetta P
5, van Ommen GJB
1, de Kimpe S
2, Ferlini A
3, van Deutekom JCT
2and Aartsma-Rus A
11
Human Genetics, Leiden University Medical Center, the Netherlands
2
Prosensa Therapeutics, the Netherlands
3
Experimental and Diagnostic Medicine, Section of Medical Genetics, University of Ferrara, Italy
4
IGM-CNR, Unit of Bologna c/o IOR, Italy
5
Histology, Microbiology, and Medical Biotechnology, University of
Padova, Italy
Molecular Therapy (2010) 18(6), 1210-7
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PK and PD studies on 2OMePS AONs in mdx
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maZm(3NL^OQ(@NMl(Zk^(lmZ[e^(Zg](aZo^(Z(_ZohkZ[e^(OJ(ikh&e^(Zg](
maZm(ma^r(\Zg(^Zlber([^(]^ebo^k^]([r(l/\/(bgc^\mbhgl/
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KZ[hkZmhkb^l(*LZZlmkb\am-(ma^(M^ma^keZg]l+/(@ee(^qi^kbf^gml(p^k^(Znmahkbs^](
Chapter 4
96
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PK and PD studies on 2OMePS AONs in mdx
97
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Chapter 4
98
