Cover Page
The handle http://hdl.handle.net/1887/87898 holds various files of this Leiden University
dissertation.
Author:
Panagiotou, M.
Sleep alterations in the course of aging
Environmental Inputs
Copyright © 2020 Maria Panagiotou ISBN: 978-94-6380-792-0
NUR: 874
Typeset using LATEX
The printing of this thesis was financially supported by: Stichting KNMP-fondsen
Avantes
Cover picture: Untitled by Zdzislaw Beksinski, oil on fibreboard, 1985 Printed by: Proefschriftmaken NL
The work in this thesis was primarily performed at the Leiden University Medical Center while some experiments took part in the Erasmus University Medical Center. The thesis was funded by the Dutch Technology Foundation STW (STW OnTime - project number 12193).
Sleep alterations in the course of aging
Environmental Inputs
Proefschrift
ter verkrijging van
de graad van doctor aan de Universiteit Leiden op gezag van de Rector Magnificus prof.mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op donderdag 14 mei 2020
klokke 11:15 uur
door
Maria Panagiotou
Promotor: Prof. J.H. Meijer
Co-promotor: Dr. T. de Boer
Promotion committee: Prof.dr. O.C. Meijer Dr. J.H.T. Rohling Prof. dr. P.E. Slagboom Mw. Dr.ir. D. van Heemst
Prof.dr. A.P. IJzerman, Leiden Academic Centre for Drug Research Prof. dr. H.-P. Landolt, University of Zurich
Do the dreams grow old? No they don’t people grow old and when dreams realize it they leave in order to find new people curl up and maybe succeed to come true this time Fani Athanasiadou
Translation: Georgia Matraka
Contents
1 GENERALINTRODUCTION ANDAIM OF THE PROJECT 9
1.1 Sleep function and mechanisms, sleep homeostasis . . . 10
1.1.1 Sleep function . . . 10
1.1.2 Measuring Sleep: the electroencephalogram (EEG) . . . 11
1.1.3 Sleep and Brain areas . . . 13
1.1.4 Sleep homeostasis . . . 14
1.1.5 Sleep deprivation . . . 17
1.2 Aging: theories, sleep and the brain . . . 18
1.2.1 Aging theories . . . 18
1.2.2 The Aging Brain and Sleep . . . 19
1.3 Environmental factors, health and aging . . . 21
1.4 Aim of the current thesis . . . 22
I Young Data
37
2 High-caloric diet and sleep homeostasis in mice 39 Chronic high-caloric diet modifies sleep homeostasis in mice European Journal of Neuroscience (2018), 47(11):1339-1352 . . . 393 Chronic caffeine consumption and sleep: a paradox? 67 Effects of chronic caffeine consumption on sleep and the sleep electroencephalo-gram in mice Journal of Psychopharmacology (2018) Oct 24:269881118806300 . . . . 67
4 Sleep and dim-light-at-night duration periods 87 Sleep network deterioration as a function of dim-light-at-night exposure dura-tion in a mouse model To be submitted . . . 87
6 Exercise, sleep and brain age 139 How old is your brain? Slow-wave activity in non-rapid-eye-movement sleep
as a marker of brain rejuvenation after long-term exercise in mice
Frontiers in Aging Neuroscience 2018 Aug 7;10:233 . . . 139
7 High-caloric diet and sleep in aged mice 167 Chronic high-caloric diet accentuates age-induced sleep alterations in mice Behavioral Brain Research 2019 Apr 19;362:131-139 . . . 167
8 Sleep and chronic dim-light-at-night in aging 197 Effects of chronic dim-light-at-night exposure on sleep in young and aged mice Neuroscience, 2020, 426: 154-167 . . . 197
9 Sleep and Aging: a Genetic Model 225 Sleep in a premature aging mouse model Manuscript in preparation . . . 225
10 General Discussion 243 10.1 Sleep characteristics in the course of aging . . . 244
10.2 Factors that impair sleep and behavior . . . 247
10.2.1 High-caloric diet . . . 247
10.2.2 Dim light at night . . . 248
10.3 Factors that enhance sleep and behavior . . . 249
10.3.1 Physical activity . . . 250
10.3.2 Caffeine . . . 251
10.4 Biomarkers of brain age: inside EEG SWA in NREM sleep . . . 253
10.5 Concluding Remarks and Future Directions . . . 254
