Cover Page
The handle http://hdl.handle.net/1887/66122 holds various files of this Leiden University
dissertation.
Author: Amatngalim, G.D.
Title: Airway epithelial innate host defence in chronic obstructive pulmonary disease
Issue Date: 2018-10-11
AIRWAY EPITHELIAL INNATE HOST
DEFENCE IN CHRONIC OBSTRUCTIVE
PULMONARY DISEASE
GIMANO DANANG AMATNGALIM
Colophon
Airway epithelial innate host defence in chronic obstructive pulmonary disease Gimano D. Amatngalim
Thesis Leiden University Medical Center ISBN: 978-90-829179-0-1
Cover: Jeffrey Zegers, Gimano Amatngalim Printing: Gildeprint, Enschede
© 2018 Gimano D. Amatngalim
AIRWAY EPITHELIAL INNATE HOST
DEFENCE IN CHRONIC OBSTRUCTIVE
PULMONARY DISEASE
PROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties ter verdedigen op 11 oktober 2018
klokke 16:15 uur
door
GIMANO DANANG AMATNGALIM
geboren te Leidschendam in 1987
PROMOTOR: Prof. dr. P..S. Hiemstra LEDEN PROMOTIECOMMISSIE: Prof. dr. C. van Kooten
Prof. dr. M. Yazdanbakhsh
Prof. dr. J. Schalkwijk (Radboudumc, Nijmegen) Dr. J.M. Beekman (UMCU, Utrecht)
“DON’T SMOKE. I DID. WISH I NEVER HAD.
LIVE LONG AND PROSPER.”
LEONARD NIMOY (SPOCK, STAR TREK)
TABLE OF CONTENTS
CHAPTER 1 General Introduction 9
CHAPTER 2 Antimicrobial peptides in chronic obstructive pulmonary 27 disease.
CHAPTER 3 Basal cells contribute to innate immunity of the airway 43 epithelium through production of the antimicrobial
protein RNase 7.
CHAPTER 4 Antibacterial defense of human airway epithelial cells from 67 chronic obstructive pulmonary disease patients induced
by acute exposure to nontypeable Haemophilus influenzae:
modulation by cigarette smoke.
CHAPTER 5 Aberrant epithelial differentiation by cigarette smoke 97 dysregulates respiratory host defense.
CHAPTER 6 Cigarette smoke modulates repair and innate immunity 127 following injury to airway epithelial cells.
CHAPTER 7 Effect of acute cigarette smoke exposure on airway 147 epithelial activation of the integrated stress response
CHAPTER 8 ADAM17 and EGFR regulate IL-6 receptor and 167 amphiregulin mRNA expression and release in cigarette
smoke-exposed primary bronchial epithelial cells from patients with chronic obstructive pulmonary disease (COPD).
CHAPTER 9 Expression of the innate immunity mediator WFDC12 193 in airway epithelial cells: role of cell differentiation and
expression in COPD
CHAPTER 10 Antimicrobial peptides and innate lung defenses: role in 211 infectious and noninfectious lung diseases and therapeutic applications.
CHAPTER 11 Summary and Discussion 225 ADDENDUM Nederlandstalige samenvatting 241
List of publications 248
Curriculum vitae 250
Dankwoord 251
