Citation
Pijnappels, D. A. (2009, June 18). Electrophysiological deterioration and resurrection in the scarred heart. Retrieved from https://hdl.handle.net/1887/13851
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/13851
Note: To cite this publication please use the final published version (if applicable).
Electrophysiological Deterioration
and Resurrection in the Scarred Heart
Copyright © 2009 Daniël A. Pijnappels, Leiden, the Netherlands. All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means, without prior written permission of the author.
Cover “Ambiguous”, oil on canvas, A. Pijnappels, 2009
Layout Dennis Dekker Productions, Alblasserdam, the Netherlands Printed by Gildeprint BV, Enschede
ISBN 978-90-9024306-1
Electrophysiological Deterioration and Resurrection in the Scarred Heart
Proefschrift
Ter verkrijging van
de graad van doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof. mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op donderdag 18 juni 2009 klokke 13:45 uur
door
Daniël Anthonie Pijnappels Geboren te Alblasserdam
in 1980
Co-Promotor Dr. D.E. Atsma
Referent
Dr. S.M. Wu (Harvard University, Boston, MA, U.S.A.)
Overige leden Prof. dr. D.L. Ypey Dr. A.A.F. de Vries
Some say the world will end in fire, Some say in ice.
From what I’ve tasted of desire, I hold with those who favor fire...
(excerpt from Fire and Ice by Robert Frost, 1920)
Voor mijn ouders en grootouders Aan Arti
Chapter II Fibroblasts from human postmyocardial infarction scars aquire properties of cardiomyocytes after transduction
with a recombinant myocardin gene — FASEB J. 2007;21:3369-79
Chapter III Resynchronization of separated rat cardiomyocyte fields with genetically modified human ventricular scar fibroblasts
— Circulation. 2007;116:2018-28
Chapter IV Normal commitment but impaired maturation of cardio- myocytes from induced pluripotent stem cells
— Submitted for publication
Chapter V Progressive increase in conduction velocity across human mesenchymal stem cells is mediated by enhanced electrical coupling
— Cardiovasc Res. 2006;72:282-91
Chapter VI Forced alignment of mesenchymal stem cells undergoing cardiomyogenic differentiation affects functional integra- tion with cardiomyocyte cultures
— Circ Res. 2008;103:167-76
Appendix I, II & III
Editorial by I.R. Efimov: Nature versus nurture in cardiac
conduction: toward integrative paradigm of cardiac tissue engineering
— Circ Res. 2008;103:119-21
Letter to the Editor by Rose RA et al.; Do mesenchymal stromal cells transdifferentiate into functional cardiomyocytes?
— Circ Res. 2008;103:e120
Reply from authors
— Circ Res. 2009;104:e8
32
56
80
110
132
158
166
170
Chapter VII Epithelial-to-mesenchymal transformation alters electrical conductivity of WT1+ human epicardial cells
— Submitted for publication
Chapter VIII Summary, Conclusions, Discussion, and Future Perspectives Samenvatting, Conclusies, Discussie en Toekomstperspectieven List of Publications
Acknowledgements Curriculum Vitae
176
200
220 226 230
