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The handle http://hdl.handle.net/1887/20090 holds various files of this Leiden University dissertation.
Author: Reedt Dortland, Arianne Klaartje Beraldine van Title: Metabolic risk factors in depressive and anxiety disorders Issue Date: 2012-11-06
Metabolic risk factors in depressive and anxiety
disorders
Arianne Klaartje Beraldine van Reedt Dortland
The infrastructure for the NESDA study (www.nesda.nl) is funded through the Geestkracht program of the Netherlands Organisation for Health Research and Development (ZonMw, grant number 10-000-1002) and is supported by participating universities and mental health care organizations (VU University Medical Centre, GGZ inGeest, Arkin, Leiden University Medical Centre, GGZ Rivierduinen, University Medical Centre Groningen, Lentis, GGZ Friesland, GGZ Drenthe, Scientific Institute for Quality of Health Care [IQ Healthcare], Netherlands Institute for Health Services Research [NIVEL] and Netherlands Institute of Mental Health and Addiction [Trimbos]). Data analyses were supported by a Netherlands Organisation for Scientific Research (NWO) grant (VIDI 917.66.320) to prof.dr. B.W.J.H. Penninx.
Financial support by the Dutch Heart Foundation and by the J.E.
Jurriaanse Foundation for the publication of this thesis is gratefully acknowledged. Further financial support for the printing of this thesis was kindly provided by Gijs Lauret, Lundbeck B.V. and Servier Nederland Farma B.V.
Cover image: Elena Ray
Cover design: Mirjam van Emden & Arianne van Reedt Dortland Editing: Arianne van Reedt Dortland
Printed by: Uitgeverij BOXPress, ‘s-Hertogenbosch ISBN: 978 90 8891 489 8
© 2012 by Arianne van Reedt Dortland
Metabolic risk factors
in depressive and anxiety disorders
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden
op gezag van de Rector Magnificus Prof. Mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
ter verdediging op dinsdag 6 november 2012 klokke 11.15 uur
door
Arianne Klaartje Beraldine van Reedt Dortland geboren te Utrecht
op 10 februari 1981
Promotores prof. dr. F.G. Zitman prof. dr. B.W.J.H. Penninx Copromotores
dr. E.J. Giltay dr. T. van Veen Promotiecommissie
prof. dr. ir. D. Kromhout (Universiteit Wageningen) prof. dr. R.C. van der Mast
prof. dr. R.C. Oude Voshaar (Universitair Medisch Centrum Groningen) prof. dr. H. Pijl
Er is iets meer waard dan een geleerde te zijn.
Dat is een mens te zijn.
Jules Gabriel Compayré (1843-1913), bron onvindbaar
Contents
Chapter 1 General introduction 11
Chapter 2 Metabolic syndrome abnormalities are associated with severity of depression and anxiety
and with tricyclic antidepressant use
29
Chapter 3 Associations between serum lipids
and major depressive disorder 45
Chapter 4 Symptom dimensions of depression and anxiety and the metabolic syndrome
61
Chapter 5 Longitudinal relationship of depressive and anxiety symptoms with dyslipidemia and abdominal obesity
79
Chapter 6 Increased sympathetic and decreased
parasympathetic activity rather than changes in hypothalamic-pituitary-adrenal axis activity is associated with metabolic abnormalities
93
Chapter 7 The impact of biological stress systems and lifestyle on dyslipidemia and obesity in anxiety and
depression
109
Chapter 8 Personality traits and childhood trauma as correlates of metabolic risk factors
125
Chapter 9 Summary and general discussion 141
References 157
List of abbreviations 175
Nederlandse samenvatting 179
Curriculum vitae 189
List of publications 193
List of co-authors 197
