University of Groningen
Mechanistic insights in the antibiotic tolerance of Pseudomonas aeruginosa biofilms Valentin, Jules
DOI:
10.33612/diss.160159324
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Publication date: 2021
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Valentin, J. (2021). Mechanistic insights in the antibiotic tolerance of Pseudomonas aeruginosa biofilms. University of Groningen. https://doi.org/10.33612/diss.160159324
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1. There are three absolute certainties in life: death, taxes, and bacterial resistance. 2. Quantifying the recovery of biofilm cells after antibiotic treatment is a good approach to assess antibiotic tolerance in Pseudomonas aeruginosa biofilms (Chapter 2). 3. The cbrB gene plays a central role in the nutrient uptake of P. aeruginosa and therefore is a target for drug development (Chapter 2). 4.
Antibiotic failure in biofilm-related infections can be predicted through quick genomic characterization of the pathogen (Chapter 3). 5. The PA0720 gene, part of the Pf1-like bacteriophage, contributes to gentamicin tolerance of P. aeruginosa biofilms (Chapter 3). 6. P. aeruginosa adapts its biofilm structure to overcome antibiotic treatment, in which the flgE gene plays a predominant role (Chapter 4). 7. Studying antimicrobial resistance of planktonic bacteria only represents the top of the iceberg. 8. Phage therapy is one of the most promising strategies against
antibiotic resistant bacteria. 9. Working in a consortium of scientists with interdisciplinary competence is one formidable way to do
science. 10. To achieve good research it is important to be extremely critical to other researchers' work and even more to your own
research.
