University of Groningen
Biolubrication enhancement for tissues and biomaterials
Wan, Hongping
DOI:
10.33612/diss.135598825
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Wan, H. (2020). Biolubrication enhancement for tissues and biomaterials: Restoration of natural lubricant function by biopolymers. University of Groningen. https://doi.org/10.33612/diss.135598825
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Propositions
Biolubrication enhancement for tissues and biomaterials Restoration of natural lubricant function by biopolymers
Hongping Wan
1. Biomacromolecules like proteins, glycoproteins, and polysaccharides support a wide range of normal and shear stresses in living systems, especially at sliding interfaces. (This thesis)
2. Successful in vitro data on new lubrication enhancement strategies should be validated ex-vivo before in vivo evaluation. (This thesis)
3. The natural lubrication system, despite being aberrant due to disease, can still be utilized instead of being abandoned or overwhelmed. (This thesis)
4. The effect at the nanoscale may not manifest itself in the same way at the macroscale. (This thesis)
5. The layered conditioning film can be rebuilt to restore lubrication both in the oral cavity and articular joints. (This thesis)
6. Both electrostatic interaction and covalent stabilization can be used to develop a layered structure of conditioning film through lubricant macromolecule recruitment. (This thesis)
7. The lubrication system between medical devices and tissue can be boosted by a strong adhesive film to function with the native lubricant fluid. (The thesis)
8. Theory and experience are essential to guide research, but they should not be a reason that prevents you from trying.
