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University of Groningen Biolubrication enhancement for tissues and biomaterials Wan, Hongping

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University of Groningen

Biolubrication enhancement for tissues and biomaterials

Wan, Hongping

DOI:

10.33612/diss.135598825

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date: 2020

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Wan, H. (2020). Biolubrication enhancement for tissues and biomaterials: Restoration of natural lubricant function by biopolymers. University of Groningen. https://doi.org/10.33612/diss.135598825

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Biolubrication

enhancement for tissues

and biomaterials

Restoration of natural lubricant function by

biopolymers

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Biolubrication enhancement for tissues and biomaterials

Restoration of natural lubricant function by biopolymers

By Hongping Wan

University Medical Center Groningen, University of Groningen Groningen, The Netherlands

This work was financially supported by the Chinese Scholarship Council

Copyright 2020 Hongping Wan Cover designed by Xinghong Zhao Printed by IPSKAMP Printing

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Biolubrication

enhancement for tissues

and biomaterials

Restoration of natural lubricant function by

biopolymers

PhD thesis

to obtain the degree of PhD at the University of Groningen

on the authority of the

Rector Magnificus Prof. C. Wijmenga and in accordance with

the decision by the College of Deans. This thesis will be defended in public on Tuesday 20 October 2020 at 9.00 hours

by

Hongping Wan

born on 9 November 1990 in Sichuan, China

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Supervisors

Prof. I.S. Zuhorn Prof. A. Herrmann

Co-supervisor

Dr. P. K. Sharma

Assessment Committee

Prof. M.M.G. Kamperman Prof. E. van der Heide Prof. F. Zhou

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Contents

Chapter 1 General introduction 1

Chapter 2 Next generation salivary lubrication enhancer derived from recombinant supercharged polypeptides for xerostomia

ACS Applied Materials & Interfaces, 2020, 12,31,

34524–34535

11

Chapter 3 Enhancement in Xerostomia Patient Salivary Lubrication using a Mucoadhesive

Journal of dental research, 2020, 99, 914–921

47

Chapter 4 A bioinspired mucoadhesive restores lubrication of degraded cartilage through reestablishment of lamina splendens.

Journal of colloids and surfaces B:biointerfaces. 2020,

193, 110977

73

Chapter 5 Nanostructured coating for biomaterial lubrication through biomacromolecular recruitment

ACS Applied materials & Interfaces, 2020, 12, 21,

23726-23736

103

Chapter 6 General discussion 137

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