University of Groningen
Development of PET tracers for investigation of arginase-related pathways
dos Santos Clemente, Gonçalo
DOI:
10.33612/diss.143845684
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
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dos Santos Clemente, G. (2020). Development of PET tracers for investigation of arginase-related pathways. University of Groningen. https://doi.org/10.33612/diss.143845684
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1 “Perhaps only in a world of the blind will things be what they truly are.”
[José Saramago in Blindness, 1995]
2 Beyond the confirmed diagnostic value through blood or tissue sampling, the potential of arginase as an imaging biomarker also seems to be undeniable.
[Chapter 2]
3 Cu-mediated 18F-fluorination can be translated to biologically active
heterocycles synthesized by multicomponent reactions.
[Chapter 3]
4 The development of 18F-fluorinated arginase inhibitors can be useful as
PET tracers for research and diagnostic.
[Chapter 4]
5 A specific “toolbox” of molecular imaging probes can be used to map arginase expression and assess statin-related mechanisms of action and provide the fundamental basis to understand statin-induced arginase/NOS signaling pathways.
[Chapter 5]
6 Robust radiofluorination procedures compatible with heteroaromatic pharmacophores may aid the drug industry in recognizing pharmacokinetics and mechanisms of action.
[Chapter 6]
7 There is always room for improvement, no matter how innovative and high-ranked the original subject is.
[Chapter 7]
8 [18F]Atorvastatin may help to identify the mechanism of action of statins,
aid in understanding the influence of sexual dimorphism, and potentially lead to a better choice of patients for statin therapy.
[Chapter 8]
9 There is a hidden therapeutic role for statins in arginase-overexpressing pathologies.
[Chapter 9]
10 “Here begins the land of phantoms.”
[Friedrich W. Murnau in Nosferatu, eine Symphonie des Grauens, 1922]
Propositions accompanying the dissertation “Development of PET tracers for investigation of
arginase-related pathways” by Gonçalo S. Clemente
