University of Groningen
Development of PET tracers for investigation of arginase-related pathways
dos Santos Clemente, Gonçalo
DOI:
10.33612/diss.143845684
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Publication date: 2020
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dos Santos Clemente, G. (2020). Development of PET tracers for investigation of arginase-related pathways. University of Groningen. https://doi.org/10.33612/diss.143845684
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Development of PET tracers for
investigation of arginase-related
pathways
The research and printing of this thesis were financially supported by:
Cover design: Sílvia Santos & Eunice da Silva (αTELAS design) Paranymphs: Eunice da Silva and Khaled Attia
End page: Tributo ao meu Alentejo (Tribute to my Alentejo)
Dissertation of University of Groningen, Groningen, The Netherlands Copyright © 2020 Gonçalo S. Clemente
Development of PET tracers for
investigation of arginase-related
pathways
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. C. Wijmenga
and in accordance with the decision by the College of Deans. This thesis will be defended in public on Wednesday 25 November 2020 at 18.00 hours
by
Gonçalo dos Santos Clemente
born on 5 December 1982 in Ferreira do Alentejo, Portugal
Supervisors Prof. dr. P. H. Elsinga Prof. dr. A. S. S. Dömling Co-supervisors Dr. A. van Waarde Dr. I. F. Antunes Assessment committee Prof. dr. G. Bormans Prof. dr. R. Leurs Prof. dr. F. J. Dekker
Chapter 1
General introduction ... 7
Chapter 2
Arginase as a potential biomarker of disease progression ... 11Chapter 3
18F-Fluorination of arylBpin scaffolds synthesized by MCR ... 67Chapter 4
18F-Fluorinated late-generation arginase inhibitors ... 95Chapter 5
Statin-induced arginase/NOS signaling pathways ... 129Chapter 6
Cu-catalyzed 18F-fluorination of atorvastatin ... 141Chapter 7
Synthesis and evaluation of [18F]atorvastatin by 18F-deoxyfluorination ... 153Chapter 8
Evaluation of [18F]atorvastatin in healthy rats ... 177Chapter 9
Concluding remarks and future perspectives ... 193Summary ... 197
Samenvatting... 203
List of abbreviations... 209
Acknowledgments ... 213
