University of Groningen
Multicomponent reactions, applications in medicinal chemistry & new modalities in drug discovery
Konstantinidou, Markella
DOI:
10.33612/diss.111908148
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Konstantinidou, M. (2020). Multicomponent reactions, applications in medicinal chemistry & new modalities in drug discovery. Rijksuniversiteit Groningen. https://doi.org/10.33612/diss.111908148
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539629-L-sub02-st-Markella 539629-L-sub02-st-Markella 539629-L-sub02-st-Markella 539629-L-sub02-st-Markella
PROPOSITIONS
for the thesis
Multicomponent reactions, applications in medicinal chemistry
& new modalities in drug discovery
Markella Konstantinidou
1. Multicomponent reaction chemistry (MCR) can be utilized for the synthesis of natural products, diverse heterocycles and has applications in medicinal chemistry.
2. MCR scaffolds are tolerating numerous post-modifications, allowing the synthesis of complex scaffolds in a few synthetic steps.
3. The clinical success of monoclonal antibodies targeting the PD-1 / PD-L1 axis has revived the field of immune-oncology.
4. The scaffold of 1,3,4-oxadiazoles has various applications in the fields of medicinal chemistry and is considered a bioisostere for amides.
5. Employing computational tools in drug discovery significantly accelerates the procedure and reduces the synthetic effort, by synthesizing only the most promising hits.
6. Proteolysis targeting chimeras are revolutionizing traditional concepts in medicinal chemistry and are changing the paradigm of “undruggable” targets. 7. Projects described as “low-hanging fruits” bear a lot of similarities with unicorns;
no-one has actually encountered them but their existence cannot be ruled out entirely.
8. “I am among those who think that science has great beauty. A scientist in his laboratory is not only a technician, he is also a child placed before natural phenomena, which impress him like a fairy tale.” [Marie Skłodowska- Curie] 9. ‘’ To every problem, there is a most simple solution.’’ [Agatha Christie] 10. Never stop learning.
