• No results found

University of Groningen Substrate exploitation of multicomponent reactions toward diverse scaffolds and applications in medicinal chemistry Li, Jingyao

N/A
N/A
Info
Downloaden
Protected

Academic year: 2021

Share "University of Groningen Substrate exploitation of multicomponent reactions toward diverse scaffolds and applications in medicinal chemistry Li, Jingyao"

Copied!
2
0
0

Bezig met laden.... (Bekijk nu de volledige tekst)

Download het nu ( 2 pagina )

Hele tekst

(1)

University of Groningen

Substrate exploitation of multicomponent reactions toward diverse scaffolds and applications in medicinal chemistry

Li, Jingyao

DOI:

10.33612/diss.150511881

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date: 2021

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Li, J. (2021). Substrate exploitation of multicomponent reactions toward diverse scaffolds and applications in medicinal chemistry. University of Groningen. https://doi.org/10.33612/diss.150511881

Copyright

Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).

Take-down policy

If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.

Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.

(2)

PROPOSITIONS

For the thesis

Substrate Exploitation of Multicomponent Reactions Toward Diverse Scaffolds and Applications in Medicinal Chemistry

Jingyao Li

1. MCR chemistry is an emerging and promising tool for organic synthesis and medicinal chemistry.

2. MCRs could efficiently enlarge scaffold diversity and provide easy access of complicated compounds with the very straightforward protocol.

3. 2-Nitrobenzyl isocyanide is a universal convertible isocyanide with extensive applicability in both Ugi-4CR and Ugi-tetrazole reactions. (chapter 1)

4. The tetrazole building block strategy fulfills the ever-increasing demand for the tetrazole-based compound libraries and novel scaffolds which are difficult to access through other methods. (chapter 2)

5. MCR and post-cyclization allow for the collective transformation of a large chemical space into a related one with different properties. (chapter 3)

6. The discovery of NH-based acid components in the Passerini reaction could have significant applications toward screening library enrichment. (chapter 4)

7. PROteolysis TArgeting Chimeras (PROTACs) have become a promising and appealing technology with great opportunities for academia and industry. (chapter 5)

8. Art is I; Science is we. [Claude Bernard]

9. Prepare yourself for the worst, and what comes afterward are all bonuses.

Referenties

Download het nu ( PDF - 2 pagina - 286.01 KB )

GERELATEERDE DOCUMENTEN

University of Groningen Multicomponent reactions, applications in medicinal chemistry & new modalities in drug discovery Konstantinidou, Markella

Advanced techniques such as radiotracers for immunoPET imaging of PD-1 checkpoint expression on tumor-infiltrating lymphocytes and PD-L1 in general might therefore become

University of Groningen Multicomponent reactions, applications in medicinal chemistry & new modalities in drug discovery Konstantinidou, Markella

The co-crystal structure of human PD-1 and PD-L1 is expected to be a valuable starting point for the design of novel inhibitors, along with the recent crystal structures

University of Groningen Multicomponent reactions, applications in medicinal chemistry & new modalities in drug discovery Konstantinidou, Markella

Then, the solvent was removed under reduced pressure and the crude reaction mixture was purified by column chromatography (eluent: PE – EA [0 to 100% EtOAc in PE]).. For

University of Groningen Multicomponent reactions, applications in medicinal chemistry & new modalities in drug discovery Konstantinidou, Markella

With the optimized one-pot reaction conditions in hand, the scope of the “Ugi-4CR/cyclization” reaction was further investigated by reacting propargylamine with

University of Groningen Multicomponent reactions, applications in medicinal chemistry & new modalities in drug discovery Konstantinidou, Markella

A Ugi 4-component reaction with indole-2-carboxylic acid and an aniline followed by a Pd-catalyzed cyclization yields tetracyclic indoloquinolines in good to moderate

University of Groningen Multicomponent reactions, applications in medicinal chemistry & new modalities in drug discovery Konstantinidou, Markella

The reaction mixture was stirred at room temperature for 24 h to obtain intermediates A; then the solvent was removed and acetic anhydride [0.5 M] and 4N HCl in dioxane (1.0

University of Groningen Multicomponent reactions, applications in medicinal chemistry & new modalities in drug discovery Konstantinidou, Markella

After the completion of the reaction, the mixture was concentrated under reduced pressure and in the residue was added aryl chloride 6 (0.75 mmol), pyridine (1 ml) and the

University of Groningen Multicomponent reactions, applications in medicinal chemistry & new modalities in drug discovery Konstantinidou, Markella

The catalytic dyad (D35 and D 219) is represented by stick models. Oxygen atoms are colored in red and nitrogen atoms in blue. On the right, close-up view of the accommodation