University of Groningen Tackling challenges to tuberculosis elimination Gröschel, Matthias Ingo Paul

University of Groningen

Tackling challenges to tuberculosis elimination

Gröschel, Matthias Ingo Paul

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date: 2019

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Gröschel, M. I. P. (2019). Tackling challenges to tuberculosis elimination: Vaccines, drug-resistance, comorbidities. University of Groningen.

Copyright

Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).

Take-down policy

If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.

Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.

Stellingen

“Tackling Challenges to Tuberculosis Elimination Vaccines, Drug-resistance, Comorbidities”

Matthias Gröschel 1st _{April, 2019}

1. The biological phenotype of ESX-1 can be safely leveraged to generate more efficacious recombinant BCG vaccines. This thesis

2. There is a trade-off between virulence and efficacy in live-attenuated vaccines such as BCG. This thesis

3. Immunotherapy for TB through therapeutic vaccines is a promising approach to turn the tide of the TB endemic. This thesis.

4. Sequence-based diagnostics as well as resistance and susceptibility prediction will greatly improve treatment for TB and MDR-TB patients. This thesis.

5. The currently used classification of the Stenotrophomonas maltophilia complex into sensu stricto and lato should be revised as all genotypic groups are able to both colonize and invasively infect humans. This thesis

6. All major S. maltophilia groups are genetically highly diverse which would justify sub-classifying them into new species. This thesis

7. The WHO End TB strategy will inevitably fail as we are approaching a historic high of TB cases.

8. TB elimination will never happen without also addressing co-morbidities and poverty.

9. Constitutive response to when something turns up is yes (Jim Smith) 10. An adult scientist is a kid who never grew up (Neil DeGrasse Tyson)