University of Groningen
Clinical and molecular phenotyping of asthma and COPD
Boudewijn, Ilse Maria
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Publication date: 2019
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Boudewijn, I. M. (2019). Clinical and molecular phenotyping of asthma and COPD. University of Groningen.
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Stellingen | Propositions Behorende bij het proefschrift
Clinical and molecular phenotyping of asthma and COPD
__________________________________________________________________________________ 1. Subjects with bronchial hyperresponsiveness, yet without any respiratory symptoms, have
less small airways dysfunction compared to asthma patients with bronchial hyperresponsiveness (this thesis).
2. Healthy subjects who show small airways dysfunction as assessed by parametric response mapping analysis of CT-scans have worse pulmonary function (this thesis).
3. Treatment of smokers and ex-smokers with asthma with extrafine particle inhaled corticosteroids (ICS) is not more effective than non-extrafine particle ICS (this thesis). 4. The presence of small airways dysfunction in smokers and ex-smokers with asthma does not
appear to be associated with a better response to extrafine particle ICS (this thesis). 5. In smokers and ex-smokers with asthma, higher blood eosinophils and lower blood
neutrophils predict a better clinical response to ICS (this thesis).
6. Bronchial provocation testing using dry powder adenosine is a suitable alternative for nebulized adenosine 5’ monophosphate (this thesis).
7. COPD patients have a nasal gene expression profile that is distinct from controls without airway disease; this profile shows significant overlap with the bronchial gene expression profile (this thesis).
8. Nasal gene expression is affected by ICS treatment in asthma and reflects corresponding changes in bronchial gene expression (this thesis).
9. Complete asthma remission is a complex phenotype in which non-coding RNAs, such as microRNAs and long non-coding RNAs, likely play a role (this thesis).
10. Het bestuderen van ‘junk-DNA’ heeft de potentie om de huidige wetenschap naar hogere sferen te tillen.
11. You start a question, and it’s like starting a stone. You sit quietly on the top of a hill; and away the stone goes, starting others … (Robert Louis Stevenson, The Strange case of Dr. Jekyll and Mr. Hyde).
12. Ik heb het nog nooit gedaan, dus ik denk dat ik het wel kan (Pippi Langkous).
