University of Groningen Intraoperative fluorescence imaging in cancer Crane, Lucia Marie Albertine

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University of Groningen

Intraoperative fluorescence imaging in cancer Crane, Lucia Marie Albertine

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Publication date:

2011

Link to publication in University of Groningen/UMCG research database

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Crane, L. M. A. (2011). Intraoperative fluorescence imaging in cancer. s.n.

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INTRAOPERATIVE FLUORESCENCE IMAGING IN CANCER L . M . A . CRANE

Promotie L.M.A. Crane Binnenwerk1 1

Promotie L.M.A. Crane Binnenwerk1 1 16-11-2010 12:05:2716-11-2010 12:05:27

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Colofon

Crane, L.M.A.

Intraoperative ﬂ uorescence imaging in cancer

Dissertation University of Groningen, with summary in Dutch

ISBN: 978-90-367-4678-6 (printed version) ISBN: 978-90-367-4679-3 (electronic version)

All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, mechanically, by photocopying, recording, or otherwise, without the written permission of the author.

Design: Marijke Crane-de Wal

Cover design: Marijke Crane-de Wal & Lucy Crane Cover picture: Stock.XCHNG

Printing: Ipskamp Drukkers, Enschede

For the printing of this thesis, ﬁ nancial sponsoring of the following institutions and com- panies is gratefully acknowledged: University of Groningen, University Medical Center Groningen (UMCG), Groningen University Institute for Drug Exploration (GUIDE), ChipSoft, Li-COR Biosciences, Caliper LifeSciences

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Intraoperative ﬂ uorescence imaging in cancer

Proefschrift

ter verkrijging van het doctoraat in de Medische Wetenschappen aan de Rijksuniversiteit Groningen

op gezag van de Rector Magniﬁ cus, dr. F. Zwarts, in het openbaar te verdedigen op

woensdag 26 januari 2011 om 14.45 uur

door

Lucia Marie Albertine Crane geboren op 5 oktober 1983

te Groningen

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Promotores: Prof. dr. T. Wiggers Prof. dr. A.G.J. van der Zee Copromotor: Dr. G.M. van Dam

Beoordelingscommissie: Prof. dr. P.J. van Diest Prof. dr. H.W. Nijman Prof. dr. R.J. Porte

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Paranimfen: Reinier F. Crane Marleen van Oosten

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All ﬁ gures referred to in the text are printed in full color on pages 193-208.

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TABLE OF CONTENTS 1. Introduction & Rationale

Part I: Sentinel lymph node imaging

2. Intraoperative multispectral ﬂ uorescence imaging for the detection of the sentinel lymph node in cervical cancer: a novel concept

3. Intraoperative near-infrared ﬂ uorescence imaging for sentinel lymph node detection in vulvar cancer: ﬁ rst clinical results

4. Optical imaging for lymph node surveillance in breast cancer patients:

intraoperative detection as a step-up approach towards tumor-targeted imaging

5. Multispectral real-time ﬂ uorescence imaging for intraoperative detection of the sentinel lymph node in gynecologic oncology

Part II: Tumor-targeted imaging

6. Animal models of oesophageal cancer and hypoxia: An overview of ap- plications, possibilities and limitations

7. Intraoperative imaging in ovarian cancer: fact or ﬁ ction?

8. Selecting potential targetable biomarkers for imaging purposes in colorectal cancer using TArget Selection Criteria (TASC): a novel target identiﬁ cation tool

9. Folate receptor-alpha and the eﬀ ect of chemotherapy on expression rates in ovarian cancer

10. Intraoperative tumor-specifi c fl uorescence imaging in ovarian cancer by folate receptor-alpha targeting: fi rst in-human results

11. Summary

Conclusions & Future perspectives 12. Nederlandse Samenvatting

List of Abbreviations

Contents Supplementary CD Color Figures

Dankwoord

Biograﬁ e / Biography

09 15 17 31

43 55 61

63 93

111 139 157

169 177

189 193

209

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