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Liver transplantation : chimerism, complications and matrix metalloproteinases Hove, W.R. ten

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Liver transplantation : chimerism, complications and matrix metalloproteinases

Hove, W.R. ten

Citation

Hove, W. R. ten. (2011, October 4). Liver transplantation : chimerism, complications and matrix metalloproteinases. Retrieved from

https://hdl.handle.net/1887/17891

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the

University of Leiden

Downloaded from: https://hdl.handle.net/1887/17891

Note: To cite this publication please use the final published version (if applicable).

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Liver transplantation

Chimerism, complications and matrix metalloproteinases

Proefschrift

ter verkrijging van

de graad van Doctor aan de Universiteit Leiden,

op gezag van de Rector Magnificus prof. mr. P.F. van der Heijden, volgens besluit van het College van Promoties

te verdedigen op dinsdag 4 oktober 2011 klokke 16:15 uur door

Willem Rogier ten Hove geboren te Oegstgeest in 1965

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Promotiecommissie

Promotor:

Prof. dr. B. van Hoek

Co-promotor:

Dr. ir. H.W. Verspaget

Overige leden:

Prof. dr. R.J. Porte Prof. dr. H.L.A. Janssen Prof. dr. A.E. Meinders Dr. L.F.S.J. Crobach

Prof. dr. P.C.W. Hogendoorn

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5

Contents

Chapter 1 7

Introduction

Chapter 2 15

Extensive chimerism in liver transplants: vascular endothelium, bile duct epithelium, and hepatocytes.

Liver Transplantation 2003;9:552-556.

Chapter 3 27

Liver chimerism after allogeneic blood stem cell transplantation.

Transplantation Proceedings 2007;39:231-236.

Chapter 4 39

MMP-2 and MMP-9 serum levels change but their gene promoter polymorphisms are not associated with late phase I/R injury or rejection after orthotopic liver transplantation.

The Open Transplantation Journal 2008;2:66-72.

Chapter 5 55

Sequential liver chemistry profiling and abdominal ultrasound assessments to predict biliary strictures after liver transplantation.

Submitted.

Chapter 6 69

Matrix metalloproteinase 2 genotype is associated with

nonanastomotic biliary strictures after orthotopic liver transplantation.

Liver International 2011;31:1110-1117.

Chapter 7 85

Chimerism as assessed by matrix metalloproteinase genotyping after orthotopic liver transplantation.

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Chapter 8 99 Summarizing discussion.

Chapter 9 109

Nederlandse samenvatting.

List of abbreviations 115

Author affiliations 117

List of publications 118

Curriculum vitae 120

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