and MMP-9 in orthotopic liver transplantation
Kuyvenhoven, J.P.Citation
Kuyvenhoven, J. P. (2005, May 31). Gelatinases in chronic liver disease. The clinical
relevance of MMP-2 and MMP-9 in orthotopic liver transplantation. Retrieved from
https://hdl.handle.net/1887/2319
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Gelatinases in Chronic Liver Disease
T he Clinical R elevance of M M P -2 and M M P -9 in O rthotop ic Liver T ransp lantation
G e la tin a s e s in C h ro n ic L iv e r D is e a s e .
T h e C lin ic a l R e le v a n c e o f M M P -2 a n d M M P -9 in O rth o to p ic L iv e r T ra n s p la n ta tio n . K u y v e n h o v e n , J o h a n P h .
T h e s is , U n iv e rs ity o f L e id e n – w ith re fe re n c e s – w ith s u m m a ry in D u tc h a n d E n g lis h . IS B N 9 0 -9 0 1 9 4 2 7 -4
N U R 8 7 8
C o v e r: Y o la n d e K u y v e n h o v e n .
P rin te d b y P rin tP a rtn e rs Ip s k a m p , E n s c h e d e , T h e N e th e rla n d s . © 2 0 0 5 . J . P h . K u y v e n h o v e n , L e id e n , T h e N e th e rla n d s .
A ll rig h ts re s e rv e d . N o p a rt o f th is th e s is m a y b e re p ro d u c e d o r tra n s m itte d in a n y fo rm , b y a n y m e a n s , e le c tro n ic o r m e c h a n ic a l, w ith o u t p rio r w ritte n p e rm is s io n o f th e a u th o r o r th e p u b lis h e r(s ), w h e n a p p ro p ria te .
Gelatinases in Chronic Liver Disease
The Clinical Relevance of MMP-2 and MMP-9 in Orthotopic Liver Transplantation
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gez ag van de Rector Magnificus Dr. D.D. Breimer,
hoogleraar in de faculteit der W iskunde en Natuurwetenschappen en die der Geneeskunde, volgens besluit van het College voor Promoties
te verdedigen op dinsdag 3 1 mei 2005 klokke 14.15 uur
door
Johannes Philippus Kuyvenhoven
geboren te KatwijkPromotor: Prof. dr. C.B.H.W. Lamers
Co-promotores: Dr. B. van Hoek Dr. ir. H.W. V erspaget
Referent: Prof. dr. T.M. van Gulik, AMC - Universiteit van Amsterdam
Overig e leden: mw. Dr. C.M.J. van Nieuwkerk, V UMC - V rije Universiteit Amsterdam Dr. J. Kwekkeboom, E MCR - E rasmu s Universiteit R o tterdam
Contents
C h a p te r 1
In tro d u c tio nM a trix m e ta llo p ro te in a s e s a n d liv e r d is e a s e : a n o v e rv ie w . O u tlin e o f th e s tu d ie s d e s c rib e d in th is th e s is .
C h a p te r 2
A s s e s s m e n t o f th e c lin ic a l s ig n ific a n c e o f s e ru m m a trix m e ta llo p ro te in a s e s M M P -2 a n d M M P -9 in p a tie n ts w ith v a rio u s c h ro n ic liv e r d is e a s e s a n d h e p a to c e llu la r c a rc in o m a .T h romb osis and H aemostasis 2 0 0 3 ; 8 9 : 7 1 8 -7 2 5 .
C h a p te r 3
P la s m a M M P -2 a n d M M P -9 a n d th e ir in h ib ito rs T IM P -1 a n d T IM P -2 d u rin g h u m a n o rth o to p ic liv e r tra n s p la n ta tio n . T h e e ffe c t o f a p ro tin in a n d th e re la tio n to s c h e m ia /re p e rfu s io n in ju ry .T h romb osis and H aemostasis 2 0 0 4 ; 9 1 : 5 0 6 -1 3 .
C h a p te r 4
S e ru m m a trix m e ta llo p ro te in a s e M M P -2 a n d M M P -9 in th e la te p h a s e o f is c h e m ia a n d re p e rfu s io n in ju ry in h u m a n o rth o to p ic liv e r tra n s p la n ta tio n .T ransp lantation P roc eeding s 2 0 0 3 ; 3 5 : 2 9 6 7 -2 9 6 9.
C h a p te r 5
A s s e s s m e n t o f s e ru m m a trix m e ta llo p ro te in a s e s M M P -2 a n d M M P -9 a fte r h u m a n liv e r tra n s p la n ta tio n : in c re a s e d s e ru m M M P -9 le v e l in a c u te re je c tio n .T ransp lantation 2 0 0 4 ; 7 7 : 1 6 4 6 -1 6 5 2 .
C h a p te r 6
P re a n a ly tic a l c o n d itio n s a n d c irc u la tin g m a trix m e ta llo p ro te in a s e s .T ransp lantation 2 0 0 5 ; 7 9 : 7 4 5 -7 4 6 .
