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Cover Page The handle http://hdl.handle.net/1887/92364 holds various files of this Leiden University dissertation. Author: Dijkmans, A.C. Title: Rational use of antibiotics Issue Date: 2020-06-02

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(1)

Cover Page

The handle

http://hdl.handle.net/1887/92364

holds various files of this Leiden University

dissertation.

Author: Dijkmans, A.C.

(2)
(3)

Rational Use

of Antibiotics

proefschrift

ter verkrijging van de graad van Doctor aan de universiteit Leiden, op gezag van Rector Magnificus prof. mr. C.J.J.M. Stolker, volgens besluit van het College voor Promoties

te verdedigen op donderdag 2 juni 2020 klokke 11:15 uur

door

Anneke Corinne Dijkmans geboren te Rhenen in 1974

design

Caroline de Lint, Voorburg (caro@delint.nl)

(4)

Chapter 1

Introduction

Chapter 2

A simplified oral flucloxacillin absorption test for patients requiring long-term treatment

Chapter 3

The simplified oral flucloxacillin absorption test: an accurate method to identify patients with inadequate oral flucloxacillin absorption

Chapter 4

The oral pheneticillin absorption test: an accurate method to identify patients with inadequate oral pheneticillin absorption

Chapter 5

Rifampin levels in daily practice: the accuracy of a single measurement

Chapter 6

Colistin: revival of an old polymyxin

Chapter 7

Colistin methanesulfonate (CMS) infusion solutions are stable over time and suitable for home administration

Chapter 8

Fosfomycin: pharmacological, clinical and future perspectives

Chapter 9

Fosfomycin as a potential therapy for the treatment of systemic infections: a population pharmacokinetic model to simulate multiple dosing regimens

Chapter 10

Pharmacokinetics of fosfomycin in patients with prophylactic treatment for recurrent E. coli urinary tract infection

Chapter 11

Recaputilation and general discussion Nederlandse samenvatting Publications Curriculum Vitae Dankwoord 7 21 31 43 51 65 83 91 113 131 149 157 164 167 168 Promotor Prof. dr. J. Burggraaf Co-promotor

Dr. I.M.C. de Visser-Kamerling, chdr, Leiden

Leden promotiecommissie

Prof. dr. A.C.M. Kroes Prof. dr. L.G. Visser

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