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Cover Page The handle http://hdl.handle.net/1887/3176524 holds various files of this Leiden University dissertation. Author: Buikhuisen, W.A. Title: Angiogenesis in mesothelioma Issue date: 2021-06-02

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Cover Page

The handle http://hdl.handle.net/1887/3176524 holds various files of this Leiden

University dissertation.

Author: Buikhuisen, W.A.

Title: Angiogenesis in mesothelioma

Issue date: 2021-06-02

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Angiogenesis in Mesothelioma

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Cover ProefschriftMaken | De Bilt

Cover image Starline / Freepik

Layout Renate Siebes | Proefschrift.nu

Printed by ProefschriftMaken | De Bilt

ISBN 978-94-6423-262-2

© Wieneke Buikhuisen 2021

All rights reserved. No part of this thesis may be reproduced, stored or transmitted in any form or by any means, without prior permission of the author, or, when applicable, of the publishers of the scientific papers.

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Angiogenesis in Mesothelioma

Proefschrift

ter verkrijging van

de graad van doctor aan de Universiteit Leiden, op gezag van rector magnificus prof.dr.ir. H. Bijl, volgens besluit van het college voor promoties

te verdedigen op woensdag 2 juni 2021 klokke 13.45 uur

door

Wieneke Alexandra Buikhuisen

geboren te Leiden

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Promotor

Prof.dr. P. Baas

Copromotor

Dr. J.A. Burgers (Antoni van Leeuwenhoek)

Leden promotiecommissie

Prof.dr. P.S. Hiemstra Prof.dr. C.A.M. Marijnen

Prof.dr. J.P. Van Meerbeeck (Universitair Ziekenhuis Antwerpen, België) Prof. S. Popat (Royal Marsden Fulham Road, London, Verenigd Koninkrijk)

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Chapter 1 General introduction and outline of the thesis 7 Chapter 2 Second-line therapy in malignant pleural mesothelioma:

a systematic review

25 Chapter 3 Thalidomide versus active supportive care for maintenance

in patients with malignant mesothelioma after first-line chemotherapy (NVALT 5): an open label, multicenter, randomised phase 3 study

59

Chapter 4 A randomised phase 2 study adding axitinib to pemetrexed-cisplatin in patients with malignant pleural mesothelioma: a single center trial combining clinical and translational outcomes

81

Chapter 5 Optimisation of response classification criteria for patients with malignant pleural mesothelioma, a validation study

107 Chapter 6 Antiangiogenic therapies for mesothelioma. What is the role

in mesothelioma treatment?

113

Chapter 7 Discussion and future perspectives 127

Appendices Nederlandse samenvatting List of publications Dankwoord Curriculum vitae 141 149 157 163

Table of contents

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