The Lambert-Eaton myasthenic syndrome Wirtz, P.W.

Citation

Wirtz, P. W. (2005, November 7). The Lambert-Eaton myasthenic syndrome. Febodruk B.V.

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The Lambert-Eaton myasthenic syndrome

Clinical, epidemiological and immunological studies

I SB N - 1 0 : 9 0 - 9 0 1 9 9 1 4 - 4 I SB N - 1 3 : 9 7 8 9 0 9 0 1 9 9 1 4 6

The Lambert-Eaton myasthenic syndrome

Clinical, epidemiological and immunological studies

Proefschrift

ter verkrijging van

de graad van D octor aan de U niversiteit L eiden, op gezag van de R ector M agnificus D r. D .D . Breimer,

hoogleraar in de faculteit der Wiskunde en Natuurwetenschappen en die der G eneeskunde,

volgens besluit van het College voor Promoties te verdedigen op maandag 7 november 2005

klokke 15.15 uur

door

C o- p romotor:

Dr. J .J .G.M. Verschuuren

R eferen t:

Prof.dr. J .H . Wokke ( Universiteit Utrecht)

O v erig e led en :

Prof.dr. J .B. K uks ( Rijksuniversiteit Groningen) Dr. B.O . Roep

Contents

Introduction

1. Introduction and aims 7

T he epidemiology of the L amb ert-E aton my asthenic sy ndrome 2. The epidemiology of myasthenia gravis, Lambert-E aton myasthenic

syndrome and their associated tumours in the northern part of the province of South Holland (J Neurol 2003;250:698-701)

3. The epidemiology of the Lambert-E aton myasthenic syndrome in the Netherlands (Neurology 2004 ;63:397-398)

21

31

Clinical characteristics of L E M S

4. Difference in distribution of muscle weakness between myasthenia gravis and the Lambert-E aton myasthenic syndrome (J Neurol Neuros urg P s y c hi atry 2002;73:766-768)

5. Differences in clinical features between the Lambert-E aton myasthenic syndrome with and without cancer: an analysis of 227 published cases (Cli n Neurol Neuros urg 2002;104 :359-363)

6. The Lambert-E aton myasthenic syndrome has a more progressive course in patients with lung cancer (M us c le & Nerve 2005;32:226-229)

7. Associated autoimmune diseases in patients with the Lambert-E aton myasthenic syndrome and their families (J Neurol 2004 ;251:1255-1259)

37

45

57

65

Immunopathogenesis of L E M S

8. HLA class I and II in Lambert-E aton myasthenic syndrome without associated tumour (H um I m m un ol 2001;62:809-813)

9. High innate production of interleukin-10 and tumour necrosis factor-

α

77

87

10. HLA and smoking in prediction and prognosis of small cell lung cancer in autoimmune Lambert-E aton myasthenic syndrome (J Neuroi m m un ol 2005;159:230-237)

11. P/Q-type calcium channel antibodies, Lambert-E aton myasthenic syndrome and survival in small cell lung cancer (J Neuroi m m un ol 2005;164 :161-165)

97

13. Summary and conclusions 137

Nederlandse samenvatting en conclusies Curriculum Vitae

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