Prediction of small cell lung cancer in the Lambert-Eaton myasthenic syndrome
Titulaer, M.J.
Citation
Titulaer, M. J. (2010, November 24). Prediction of small cell lung cancer in the Lambert-Eaton myasthenic syndrome. Department of Neurology, Faculty of Medicine / Leiden University Medical Center (LUMC), Leiden University. Retrieved from https://hdl.handle.net/1887/16174
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Prediction of small cell lung cancer
in the
Lambert-Eaton myasthenic syndrome
Maarten J. Titulaer
Cover photograph: The constellation Cancer. It has been used by the courtesy of Prof.dr. J.B. Kaler, professor emeritus of Astronomy, University of Illinois, Urbana, IL, USA
Printing: Ridderprint BV, Ridderkerk ISBN 978-905335-338-7
Copyright © M.J. Titulaer, 2010
Prediction of small cell lung cancer
in the
Lambert-Eaton myasthenic syndrome
Proefschrift
ter verkrijging
van de graad van Doctor aan de Universiteit Leiden, op gezag van de Rector Magnificus prof.mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op woensdag 24 november 2010
klokke 16.15 uur
door
Maarten Jan Titulaer geboren te Hengelo in 1977
Promotiecommissie
Promotores:
Prof.dr. J.J.G.M. Verschuuren Prof.dr. R.A.C. Roos
Co-promotor:
Dr. P.W. Wirtz (HagaZiekenhuis, Den Haag)
Leden:
Prof.dr. J. Dalmau (University of Pennsylvania, Philadelphia, PA, USA) Prof.dr. J.G. van Dijk
Prof.dr. P.A.E. Sillevis Smitt (Erasmus Universiteit, Rotterdam)
The studies described in this dissertation were supported in part by a European Neurological Society fellowship, the Leiden University Medical Center, the European Union research project “PNSEuronetwork”, contract number LSSM-CT 2005-518174, another grant from the European Union (QLG1-CT-2002-01756), PI030028 Fondo de Investigaciones Sanitarias, Spain and by the Prinses Beatrix Fonds, the Netherlands. The funding sources had no involvement at all in any part of the study design or manuscript writing.
Printing of this thesis was supported financially by the Stichting het Remmert Adriaan Laan Fonds.
Contents
Chapter 1 Introduction and aims 7
(Ann N Y Acad Sci 2008;1132:129-34 ; Neurology 2008;70:86) Chapter 2 Similar epidemiological features in Lambert-Eaton myasthenic
syndrome and myasthenia gravis suggest common 25 pathophysiological mechanisms
Chapter 3 The Lambert-Eaton myasthenic syndrome 1988-2008. A clinical
picture in 97 patients 39
(J Neuroimmunol 2008;201-202:153-8)
Chapter 4 SOX1 antibodies are markers of paraneoplastic Lambert-Eaton
myasthenic syndrome 51
(Neurology 2008;70:924-8)
Chapter 5 SOX antibodies in small cell lung cancer and Lambert-Eaton
myasthenic syndrome: frequency and relation with survival 65 (J Clin Oncol 2009;27:4260-7)
Chapter 6 The clinical DELTA-P score accurately predicts small cell lung cancer in the Lambert-Eaton myasthenic syndrome 87 (submitted)
Chapter 7 Screening for small-cell lung cancer: a follow-up study of
100 patients with Lambert-Eaton myasthenic syndrome 111 (J Clin Oncol 2008;26:4276-81)
Chapter 8 Screening for tumours in paraneoplastic syndromes:
report of an EFNS task force 127
(Eur J Neur 2010, accepted)
Chapter 9 Summary, conclusions and future perspectives 151 Samenvatting, conclusies en visie op de toekomst 161
List of publications 173
Curriculum vitae 175
