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Damage recognition in nucleotide excision repair

Malta, E.

Citation

Malta, E. (2008, December 9). Damage recognition in nucleotide excision repair. Retrieved from https://hdl.handle.net/1887/13327

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden

Downloaded from: https://hdl.handle.net/1887/13327

Note: To cite this publication please use the final published version (if applicable).

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Damage recognition in Nucleotide Excision Repair

PROEFSCHRIFT

ter verkrijging van

de graad van Doctor aan de Universiteit Leiden,

op gezag van Rector Magnificus prof. mr. P.F. van der Heijden, volgens besluit van het College voor Promoties

te verdedigen op dinsdag 9 december 2008 te klokke 10.00 uur

door Erik Malta

geboren te Vlaardingen in 1980

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Promotiecommissie:

Promotor: Prof. dr. J. Brouwer Co-promotor: Dr. N. Goosen

Referent: Prof. dr. L.H.F. Mullenders Overige leden: Prof. dr. R. Kanaar

(Erasmus Universiteit Rotterdam) Prof. dr. C. Kisker

(University of Würzburg, Germany)

Printed by Gildeprint B.V., Enschede, The Netherlands

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Voor mijn vader Dla Agatki

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Contents

Chapter 1

Chapter 2

Chapter 3

Chapter 4

Chapter 5

Introduction

Dynamics of the UvrABC nucleotide excision repair proteins analyzed by fluorescence resonance energy transfer.

Base flipping in nucleotide excision repair.

Functions of base flipping in E. coli nucleotide exci- sion repair.

Fluorescent DNA modifications to study nucleotide excision repair

Summary and general discussion Samenvatting en algemene discussie Curriculum vitae

List of publications Dankwoord

7

65

85

107

127

147 152 157 158 159

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