The endocannabinoid system is a key player in adipose tissue function - Endocannabinoids provide an autocrine/paracrine negative feedback loop in adrenergic stimulation of adipose tissue

Brown adipose tissue: an endocrine organ specialized in dissipating energy that is stored in the form of triglycerides into heat.. Browning: a process in which white adipocytes

Plasma levels of the endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide (N- arachidonoylethanolamine, AEA), and related N-acylethanolamines, were quantified by UPLC-MS/MS

Although it remains speculative, high endocannabinoid levels may deteriorate endocannabinoid signaling in metabolic organs, including skeletal muscle, and thereby may contribute

Because of the profound role of FGF1 in the regulation of glucose metabolism and its evident dependence on adipose tissue, we examined the effects of FGF1 on

Injection of R1MAb into obese mice had effects highly similar to FGF21 treatment, and included improvement of serum insulin, lipid, and blood glucose levels and

In an attempt to further specify a role for TUB in energy homeostasis and disease in humans, we investigated the expression and distribution patterns of TUB

We conclude that FGF1 lowers blood glucose levels via FGFR1 signaling in adipose tissue, independent of MEK-ERK, which results in crosstalk between the adipose and the

3) The acute blood glucose lowering properties of pharmacologically administered FGF1 depend on a complex interplay between adipose and muscle. - This thesis. 4) Whereas the role