University of Groningen
Adipose tissue
Nies, Vera
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Publication date: 2017
Link to publication in University of Groningen/UMCG research database
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Nies, V. (2017). Adipose tissue: Target and toolbox for the treatment of metabolic disease. Rijksuniversiteit Groningen.
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Adipose tissue: Target and toolbox for the
treatment of metabolic disease
The research described in this thesis was conducted at the Department of
Pediatrics, Section Molecular Metabolism and Nutrition, University Medical Center Groningen, The Netherlands. This project was funded by the Dutch Diabetes Foundation, Grant no 2012.00.1537, and by the Jan Kornelis de Cock stichting.
The printing of this dissertation was financially supported by: The University of Groningen
The University Medical Center Groningen
the Groningen University Institute for Drug Exploration (GUIDE)
Cover Design: Vera Nies Layout: Vera Nies
Printed by: Ridderprint B.V., Ridderkerk, The Netherlands ISBN: 978-90-367-9739-9 (Digital version)
ISBN: 978-90-367-9740-5 (Printed version)
© 2017 Vera Nies. All rights reserved. No parts of this thesis may be reproduced, stored or transmitted, in any form or by any means, without permission of the author.
Adipose ti ssue: Target and toolbox for the
treatment of metabolic disease
Proefschrift
Ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnifi cus prof. dr. E. Sterken en volgens besluit van het College voor Promoti es.
De openbare verdediging zal plaatsvinden op woensdag 24 mei 2017 om 12:45 uur
door
Vera Johanna Maria Nies
geboren op 20 november 1987Promotores Prof. dr. J.W. Jonker Prof. dr. H.J. Verkade Beoordelingscommissie Prof. dr. F. Kuipers Prof. dr. M.C. Harmsen Prof. dr. E. Kalkhoven
Voor mijn ouders,
mijn zusje en mijn broertje
The most exciting phrase to hear in science, the one that heralds
new discoveries, is not “Eureka!” but “That’s funny...”
— Isaac Asimov
Paranimfen
Dicky Struik Irene Zwarts
General introduction
Fibroblast growth factor signaling in metabolic regulation FGF1 stimulates acute and chronic glucose uptake via ERK-dependent regulation of GLUT1 and GLUT4 in 3T3-L1 adipocytes
The effects of FGF1 on glucose homeostasis in mouse models of type 1 diabetes
FGF1 stimulates peripheral glucose disposal independent of MEK-ERK activation in type 2 diabetic mice
TUB gene expression in hypothalamus and adipose tissue and its association with obesity in humans
General discussion, conclusion and future prospects Summary in English
Samenvatting in het Nederlands Acknowledgements/Dankwoord Biography/Biografie Publication list
