University of Groningen
The effects of exposure to environmental chemicals on child development
Berghuis, Sietske Anette
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2018
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Berghuis, S. A. (2018). The effects of exposure to environmental chemicals on child development.
University of Groningen.
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The effects of exposure to
environmental chemicals
on child development
The effects of exposure to environmental chemicals on child development
© 2018 S.A. Berghuis, Groningen, the Netherlands
The copyright of the articles that have been published has been transferred to the respective journals. No parts of this thesis may be reproduced or transmitted in any form by any means, without prior permission of the copyright owner.
ISBN: 978-94-034-0493-6
ISBN electronic version: 978-94-034-0492-9
The printing of this thesis was financially supported by University of Groningen, University Medical Center Groningen, postgraduate school for Behavioral and Cognitive Neurosciences.
Cover design: Gerdine Kruizinga Printing and layout: Gildeprint
3
The effects of exposure to
environmental chemicals
on child development
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op maandag 30 april 2018 om 14.30 uur
door
Sietske Annette Berghuis
geboren op 14 maart 1989The effects of exposure to
environmental chemicals
on child development
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
maandag 30 april 2018 om 14.30 uur
door
Sietske Annette Berghuis
geboren op 14 maart 1989 te Groningen
3
The effects of exposure to
environmental chemicals
on child development
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op maandag 30 april 2018 om 14.30 uur
door
Sietske Annette Berghuis
geboren op 14 maart 1989Promotores
Prof. dr. A.F. Bos Prof. dr. P.J.J. Sauer
Copromotor
Dr. G. Bocca
Beoordelingscommissie
Prof. dr. M. van den Berg
Prof. dr. M. van Eck van der Sluijs-van de Bor Prof. dr. B.H.R. Wolffenbuttel
TABLE OF CONTENTS
Chapter 1 General introduction and outline 7
Part 1 The neurotoxic effects of exposure to environmental chemicals during childhood: an overview
Chapter 2 Developmental neurotoxicity of persistent organic pollutants: 17 an update on childhood outcome
Archives of Toxicology 2015, 89(5), 687-709
Part 2 Exposure to environmental chemicals and neurological functioning from birth up to and including adolescence
Chapter 3 Prenatal exposure to polychlorinated biphenyls and their 55 hydroxylated metabolites is associated with motor development
of three-month-old infants
Neurotoxicology 2013, 38, 124-130
Chapter 4 Prenatal exposure to polychlorinated biphenyls and their 73 hydroxylated metabolites is associated with neurological functioning in 3-month-old infants
Toxicological Sciences 2014, 142(2), 455–462
Chapter 5 The effects of prenatal exposure to organohalogen compounds on 91 infant’s mental and motor development at 18 and 30 months of age
Submitted
Chapter 6 The effects of prenatal exposure to persistent organic pollutants 113 on neurological development during adolescence
Submitted
Part 3 Endocrine disrupting effects of environmental chemicals
Chapter 7 Polychlorinated biphenyl exposure and deiodinase activity in young 135 infants
Science of The Total Environment 2017, 574, 1117-1124
Chapter 8 The effects of prenatal exposure to persistent organic pollutants on 157 pubertal development
Submitted
Chapter 9 General discussion and future perspectives 175 Chapter 10 Summary 197 Nederlandse samenvatting 203
Dankwoord 209
About the author 213
