University of Groningen
Neuroinflammation as common denominator in heart failure associated mental dysfunction
Gouweleeuw, Leonie
DOI:
10.33612/diss.122192415
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Publication date:
2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Gouweleeuw, L. (2020). Neuroinflammation as common denominator in heart failure associated mental
dysfunction: Studies in animal models. University of Groningen. https://doi.org/10.33612/diss.122192415
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Neuroinflammation as common denominator
in heart failure associated mental dysfunction
Studies in animal models
Neuroinflammation as common denominator in heart failure associated mental dysfunction Studies in animal models
The studies described in this thesis were carried out at the department of neurobiology, part of the Groningen Institute for Evolutionary Life Sciences (GELIFES) at the University of Groningen.
The printing of this thesis was financially supported by the Groningen Graduate School for Science and Engineering and the University of Groningen Library.
Layout: Jules Verkade, persoonlijkproefschrift.nl Cover Design: Jules Verkade, persoonlijkproefschrift.nl Printed by: Ridderprint | www.ridderprint.nl ISBN: 978-94-034-2448-4 (printed version)
978-94-034-2447-7 (digital version) ©Copyright 2020 L. Gouweleeuw
All rights reserved, no part of this publication may be reproduced or transmitted in any form or by any means, without permission from the author
Table of contents
Chapter 1
General introduction 7
Chapter 2
The role of neutrophil gelatinase associated lipocalin (NGAL) as biological constituent linking depression and cardiovascular disease.
21
Chapter 3
Evidence for neuroinflammation after myocardial infarction in a mouse model 49 Chapter 4
Sex specific associations between microglia activity and behaviour after cardiac surgery in rats
65
Chapter 5
Differences in the association between behavior and neutrophil gelatinase-associated lipocalin in male and female rats after coronary artery ligation.
81
Chapter 6
Neutrophil gelatinase-associated lipocalin and microglial activity are associated with distinct postoperative behavioral changes in rats.
109 Chapter 7 General discussion 123 Summary 138 Nederlandse samenvatting 144 Dankwoord 150 Curriculum Vitae 153 List of publications 154
