University of Groningen
Clinical and spinal radiographic outcome in axial spondyloarthritis
Maas, Fiona
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Publication date: 2017
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Maas, F. (2017). Clinical and spinal radiographic outcome in axial spondyloarthritis: Results from the GLAS cohort. Rijksuniversiteit Groningen.
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Clinical and spinal radiographic outcome
in axial spondyloarthritis
Results from the GLAS cohort
ISBN: 978-90-367-9645-3
ISBN: 978-90-367-9644-6 (e-book) Cover design Agnes Schuur
Layout Legatron Electronic Publishing, Rotterdam, The Netherlands Printed by Ipskamp Printing, Enschede, The Netherlands.
© Fiona Maas, Groningen, 2017.
All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, without permission of the author.
The GLAS cohort was financially supported by unrestricted grants from Pfizer BV, Abbvie BV, and UCB Pharma BV.
The printing of this thesis was financially supported by the Graduate School of Medical Sciences of the University Medical Center Groningen, University of Groningen, Pfizer BV, Celgene BV, UCB Pharma BV, and Abbvie BV.
Clinical and spinal radiographic outcome
in axial spondyloarthritis
Results from the GLAS cohort
Proefschrift
ter verkrijging van de graad van doctor aan de
Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken
en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
woensdag 8 maart 2017 om 14.30 uur
door
Fiona Maas
geboren op 24 september 1988
te Ten Boer
Promotor Prof. dr. H. Bootsma Copromotores Dr. A. Spoorenberg Dr. S. Arends Beoordelingscommissie
Prof. dr. D.M.F.M. van der Heijde Prof. dr. W.F. Lems
CONTENT
Chapter 1 General introduction 11
PART I Radiographic outcome of excessive bone formation in AS patients
treated with TNF-α inhibitors
Chapter 2 Spinal radiographic progression in patients with ankylosing spondylitis 27 treated with TNF-α blocking therapy: a prospective longitudinal
observational cohort study
Chapter 3 Reduction in spinal radiographic progression in ankylosing spondylitis 47 patients receiving prolonged treatment with TNF-α inhibitors
Chapter 4 Ankylosing spondylitis patients at risk of poor radiographic outcome 73 show diminishing spinal radiographic progression during long-term
treatment with TNF-α inhibitors
Chapter 5 Radiographic damage and progression of the cervical spine in 93 ankylosing spondylitis patients treated with TNF-α inhibitors:
facet joints vs. vertebral bodies
Chapter 6 Incorporating the cervical facet joints in the mSASSS is of additional 115 value in the evaluation of radiographic outcome in ankylosing spondylitis
Part II Radiographic outcome of excessive bone loss in AS patients
Chapter 7 Radiographic vertebral fractures develop in patients with ankylosing 137 spondylitis during 4 years of TNF-α blocking therapy
Chapter 8 Clinical risk factors for the presence and development of vertebral 157 fractures in patients with ankylosing spondylitis
Part III Influence of gender and BMI on disease outcome and the development of a physical activity questionnaire for axial SpA
Chapter 9 Male and female patients with axial spondyloarthritis experience 181 disease activity, physical function, and quality of life differently:
results from the GLAS cohort
Chapter 10 Obesity is common in axial spondyloarthritis and associated with 189 poor clinical outcome
Chapter 11 Disease-specific questionnaire to assess physical activity in patients 203 with axial spondyloarthritis: the axSpA-SQUASH
Chapter 12 Summary and General Discussion 251
Chapter 13 Nederlandse Samenvatting 277 Dankwoord 287
Curriculum Vitae 291
