University of Groningen
Sensing dengue and chikungunya virus (co-) infections Aguilar Briseño, Alberto
DOI:
10.33612/diss.172910464
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Publication date: 2021
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Aguilar Briseño, A. (2021). Sensing dengue and chikungunya virus (co-) infections. University of Groningen. https://doi.org/10.33612/diss.172910464
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Propositions
belonging to the PhD thesisSensing dengue and chikungunya virus (co-) infections
1.- To our advantage, human PBMCs are a representative and an easily manipulatable model to study the kinetics and quality of systemic innate immune responses during DENV and CHIKV infections. (This thesis)
2.- Human monocytes represent the first line of defense against infectious diseases. Yet, a fraction serves as primary targets for DENV and CHIKV infections complicating the identification of pro and antiviral mechanisms. (This thesis).
3.- The use of combined high-dimensional single cell technologies for generating phenotypical, transcriptional and proteomics data, will be instrumental to disentangle the complexity of mechanisms underlying the innate immune response to DENV and CHIKV infections.
4.- Like the Yin and the Yang, Toll-like receptor 2 plays a double-sword for defense and offense in the course of DENV infection. Therefore, its dichotomous role should be considered for designing targeted therapies. (This thesis)
5.- Endothelial cells possess important features of innate immune cells like cytokine secretion, sensing of PAMPs and DAMPs, cross-talk with leukocytes, heterogeneity and plasticity. Thus, they should be considered part of the innate immune system.
6.- Increased frequencies of Intermediate Monocytes (IM) often associate with severe symptoms of inflammatory diseases. Interestingly, while DENV infection increases IM frequencies, frequencies of classical monocytes but not that of IM correlate with severe disease. Ergo, changes in monocyte subsets distribution should not be considered as a sole marker of aberrant responses. (This thesis)
7.- The correct diagnosis of the etiological agent(s) of septic or DENV patients is vital for a favorable outcome. Thus, by understanding the complexity and variety of mechanisms underlying these diseases we can design personalized therapies accordingly. (This thesis)
8.- The COVID-19 pandemic serves as a reminder of how serious viral diseases can manifest and wreak havoc on society. Hence, to stay ahead of future pandemics, a more united effort among virologist, immunologist and pharmacologist will be paramount.
9.- It is important to draw wisdom from different places. If you take it from only one place, it becomes rigid and stale. (Uncle Iroh, Avatar the last airbender)
10.- Accept the things you cannot change. Have the courage to change the things you can and have the wisdom to know the difference. (Adapted from the Serenity prayer of Reinhold Niebuhr)
José Alberto Aguilar Briseño July 5th, 2021
