The role of the second heart field in pulmonary vein development : new insights in the origin of clinical abnormalities
Douglas, Y.L.
Citation
Douglas, Y. L. (2010, October 20). The role of the second heart field in pulmonary vein development : new insights in the origin of clinical abnormalities. Retrieved from https://hdl.handle.net/1887/16065
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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The Role of the Second Heart Field in Pulmonary Vein Development
New insights in the origin of clinical abnormalities
Yvonne Louise Douglas
Colofon
The Role of the second heart field in pulmonary vein development New insights in the origin of clinical abnormalities
Yvonne Louise Douglas
This thesis was prepared at the Department of Anatomy and Embryology of the Leiden University Medical Center, Leiden, The Netherlands.
Cover
Design by Jos Dijkstra
Layout
Gildeprint Drukkerijen
Printed by Gildeprint Drukkerijen - www.gildeprint.nl
Copyright © 2010 Yvonne L. Douglas
All rights reserved. No part of this book may be reproduced or transmitted, in any form or by any means, without written permission of the author.
ISBN: 978-94-6108-060-8
Financial support for the publication of this thesis by the following companies is gratefully acknowledged: Baxter B.V., Edwards Lifesciences B.V., Krijnen Medical B.V., Maquet Netherlands B.V., Maquet Cardiac Assist (Datascope) B.V., St Jude Medical Nederland B.V., Sorin Group Nederland B.V., Vascutek Nederland B.V.
The Role of the Second Heart Field in Pulmonary Vein Development
New insights in the origin of clinical abnormalities
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus Prof. Mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op woensdag 20 oktober 2010
klokke 16.15 uur door
Yvonne Louise Douglas
geboren te Amsterdam in 1964
Promotiecommissie
Promotores: Prof. Dr. A.C. Gittenberger- de Groot Prof. Dr. M.C. de Ruiter
Co-promotor: Dr. M.R.M. Jongbloed
Overige leden: Prof. Dr. M.G. Hazekamp Prof. Dr. N.A. Blom Dr. M.Th.E. Bink-Boelkens
Financial support of the Netherlands Heart Foundation and of the J.E. Jurriaanse Stichting for the publication of this thesis is gratefully acknowledged.
Aan mijn ouders Voor Jos, Frits, Pien en Jur
Contents
Chapter 1 General introduction 9
Chapter 2 Histology of vascular-myocardial wall of left atrial body 27 after pulmonary venous incorporation.
Am J Cardiol 2006;97:662-70.
Chapter 3 Pulmonary vein, dorsal atrial wall and atrial septum 45 abnormalities in podoplanin knockout mice with
disturbed posterior heart field contribution.
Pediatr Res 2009;65:27-32.
Chapter 4 Pulmonary vein and atrial wall pathology in human total 65 anomalous pulmonary venous connection.
Int J Cardiol 2009;134:302-12.
Chapter 5 Unilateral pulmonary vein stenosis with a contralateral 89 pulmonary varix.
J Thorac Cardiovasc Surg 2007;134:496-501.
Chapter 6 General Discussion: Normal and abnormal development 101 of pulmonary veins: state of the art and correlation with
clinical entities.
Int J Cardiol, in press.
Summary 141
Samenvatting 145
List of publications 149
Acknowledgements 153
Curriculum vitae 157
