University of Groningen
Chronic social stress and the circadian system
Ota, Simone Marie
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Publication date: 2019
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Ota, S. M. (2019). Chronic social stress and the circadian system: Effects on the central clock and peripheral liver oscillator. University of Groningen.
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Chronic social stress and the
circadian system
The project presented in this thesis was a collaboration between the University of Groningen (RUG), The Netherlands, and Universidade Federal de São Paulo (UNIFESP), Brazil. The research was carried out in the Chronobiology group at the Groningen Institute for Evolutionary Life Sciences (GELIFES - RUG) and the Group of Studies on the Neurobiology of Stress and its Disorders at the Department of Psychobiology (UNIFESP). The study was supported by a Bernoulli scholarship from the Faculty of Science and Engineering at the RUG, and a scholarship from Coordenação de Aperfeicoamento de Pessoal de Nível Superior (CAPES), Brazil.
Layout Simone Marie Ota Illustrations Simone Marie Ota Cover Simone Marie Ota
Printed by Ridderprint BV | www.ridderprint.nl ISBN 978-94-034-1557-4 (printed version) ISBN 978-94-034-1556-7 (electronic version)
Chronic social stress and the
circadian system
Effects on the central clock and peripheral liver oscillator
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus prof. E. Sterken
and in accordance with the decision by the College of Deans. This thesis will be defended in public on
Friday 24 May 2019 at 16:15 hours
by
Simone Marie Ota
born on 24 February 1987 in Santo André, Brazil
Supervisors
Prof. R.A. Hut Prof. D. Suchecki
Co-supervisor
Dr. P. Meerlo
Assessment Committee
Prof. A.J.W. Scheurink Prof. F. Gaspar do Amaral Prof. A. Kalsbeek
Table of contents
Ch. 1 General Introduction 7
Ch. 2 Effects of stress and stress hormones on endogenous clocks and circadian 15
rhythms: a review Ch. 3 Chronic social defeat stress suppresses locomotor activity but does not 35
affect the free-running circadian period of the activity rhythm in mice Ch. 4 Chronic social defeat stress affects the circadian rhythm of PERIOD2 53
expression in the liver but does not affect the suprachiasmatic nucleus Ch. 5 Corticosterone delays the phase of PERIOD2 circadian expression in 67
isolated liver tissue in vitro Ch. 6 Continuous social defeat for ten days did not induce permanent 79
behavioral alterations in adult mice Ch. 7 General Discussion 91 Dutch Summary 101 English Summary 105 Portuguese Summary 109 Acknowledgements 113 List of publications 117 Curriculum Vitae 118
